fresh Q updates still unsure Flashcards
1
Q
affected by acetylator slow fast status
A
nitrazepam
2
Q
MAOI can cause dependence
A
trancylopramine
3
Q
prolong QTC normal doses
A
trazadone
4
Q
anti dementia drug no hepatic involvement
A
rivastigmine
5
Q
phenelzine useful for
A
social phobia
6
Q
efficacy antiPs determined by nigrostriatal binding etc - true or false
A
false
7
Q
steady state concentration of drug is doubled by what
A
doubling admin rate
8
Q
MAOIS short or fast Half life
A
short
9
Q
more than 2 copies CYP gene
A
ultra rapid metaboliser
10
Q
trancyclopromine to paroxetine
A
wait 2 weeks
11
Q
HIV cells least likely affected
A
neurones
12
Q
cerebral torque disturbance
A
psychosis
13
Q
increased what at axon prior to depolarisation
A
potassium
14
Q
increased or decreased glutamate in Alzheimers
A
increased
15
Q
cleft palate in preg
A
SSRI and lamotrigine
16
Q
does hypertension happen with SSRIs
A
no
17
Q
clozapine seizure risk increased by
A
0.1
18
Q
Flumazenil competitive or non
A
competitive
19
Q
more potent inhibitor paroxetine or sertraline
A
paroxetine
20
Q
phencylicidine acts on which receptor mimic schizophrenia symptoms
A
NMDA
21
Q
d2 inhibitory or excitatory
A
inhibitory
22
Q
5HT auto regulatory function
A
5HT1b
23
Q
how does methylphenidate work
A
NDRI
24
Q
highly selective dopamine antagonist
A
amisulpride/sulpride
25
PTSD eye movements REm
increased
26
delirium tremens EEG
low voltage fast activity
27
fluoxetine to duloxetine switch
stop and start other immediately
28
trazodone to mirtaz
cross taper
29
amitryptiline to SSRI
half dose start new then withdrawal
30
agranuloctysos risk
older and female, asian/jewish
31
neutropenia risk
young black low baseline WCC
32
weight gain antiPs more significant in
children
33
non ionising, look at blood flow/oxygen metabolism
f-MRI
34
is COMT involved in serotonin
no
35
vortioxetine action is on
5HT3
36
agranulocytosis risk after 1 year
0.01%
37
less likely manic switch
sertraline
38
disulfiram side effect
headache
39
carbamazepine can raised level of
phenytoin
40
slow rhythmic disorder affects extremiteies
athetosis
41
alpha 2 agonist with less hypotension
lofexidine
42
sibutramine for weight loss can cause what
serotonin syndrome, collapse
43
zopiclone acts on what exactly
alpha 1 subunit of omega 1
44
counteract effect opioids and help stop use
naltrexone
45
depot longest half life
palperidone
46
best antiP if low sodium
clozapine
47
modafinil acts on which neurotransmitter
dopamine
48
which ion flows into neurons to propagate action potentials
sodium
49
commonly raised hormone in depression
CRH
50
12-16hz sleep
sleep spindles stage 2
51
stroop test for
selective attention, inhibitory control
52
most abundant fast excitatory
glutamate
53
d amphetamine schizophrenia test affects what area brain
striatum
54
initial release dopamine alcohol addiction
Ventral tegmental area
55
how to benefit PTSD sleep disturbance
reduce REM latency
56
decreased volume of what in autism
corpus callosum
57
neurotransmitter shuttles through astrocytes
glutamate
58
testing to confirm Williams
FISH
59
endoscope function
degradation of lipids
60
epigenetic mechanism most associated with schizophrenia
DNA methylation
61
frontal lobe proprotion
37-41%
62
what most commonly uses glutamate as transmitter
granular and pyramidal cells
63
cell type conveying motor signals
pyramidal
64
trazodone to mirtazepine
cross taper with caution
65
wolf P White ass with lithium?
no
66
bentos work as
allosteric modulator
67
carbidopa works how
inhibits DOPA decarboxylase
68
SSRIs increase bleeding risk how
inhibit transport responseible for uptake serotonin into platelets
69
which 2 mood stablisers together increase serum concs
lamotrigine and valproate
70
attention and task switching skills?
trail making test
71
hallmark memory deficit korsakoffs
anterograde
72
difficulty coordinating movements right arm
corticobasal degeneration
73
pure maternal inheritence
Leber's
74
T/F: most rare copy number mutations are unique schizophrenia
false
75
is there strong or weak link between alcohol dep. and copy number variations Cr5
strong link
76
unilateral anosmia
frontal lobe sign
77
bulbar palsy
wasting tongue
78
west syndrome EEG
hypsarrythmia
79
brain region which limits empathetic expression?
supra marginal gyrus
80
IG what to be tested in anti NMDA encephlaitis
IGG
81
5HT1 is what coupled
G coupled
82
5HiAA in aggressive impulsive and also in suicidal patients
low
83
PTSD sleep disturbance would show
greater REM density
84
enzyme pair precursor to amyloid products in Alzheimers
gamma and beta
85
reward pathway
mesolimbic
86
primary dopamine pathway
L-phenyla to L tyrosine to L dopa to dopamine
87
increased D2 in basal ganglia in what
parkinsons
88
night terrors what stage
mostly 4 also 3 to 4 transition
89
least likely nuclei to degenerate in old age
Inferior
90
secondary messenger CNS
calcium
91
enzyme preclude amyloid formation
alpha
92
part of brain most assoc with prior disease
cerebellum
93
tremor Hz in PD
4-6Hz
94
tau effect microtubules
stablises
95
part brain affected cocaine
nucleus accumbens
96
main rate limiting step alcohol
alcohol dehygrogenase
97
target where in TMS depression
left frontal
98
best technique for tract specific lesion
DTI
99
earliest histological change in Alz
amyloid
100
recent focus genetic research ass with intellectual deficits
copy number variations
101
insulin like growth factor secreted from?
liver
102
EEGs for seizures, specific or sensitive
specific
103
subcortical or periventricular opacities more likely in old person with depression
subcortical
104
area not involved in wakefulness
cerebellum
105
is glycation epigenetic
no
106
semanticc dementia, difficulty naming, area affected?
ant tempiral
107
anomia area affected
arcuate fasciculus
108
most abundant dopamine in brain
D1
109
measures extent myelination
DTI
110
hypoperfusion.metabolism where in LBD
occipital parietal region
111
sulphide first pass effect?
low
112
at high dose duloxetine also does what
inhibits dopamine
113
donepezil metabolised by
2D6 and 3A4
114
stopped suddenly v likely to have withdrawals
venlafaxine
115
benzos decrease or increase neuronal excitability
decrease
116
melatonin also binds to
5ht2c
117
is desipramine a prodrug
no a metabolite
118
how many stages before general use
5
119
sertraline active metabolite
N desmethyl sertraline
120
food effect on lurasidone
increases absorption
121
is pregabalin metabolised
no excreted without
122
high rate behavioural side effects
leviteracetam
123
sertraline percet protein bound
98
124
target OCD in brain stimulation
STN
internal capsule
125
bipolar animal models
circadian rhythm disturbance
BNDF mice
126
anterior insula in addiction
affected yes - craving
127
suicidality neuro changes
tryptophan polymorph
cytokine excess
microglia activation
128
venlafaxine half life
3-7 hours, approx 5
129
schizophrenigenic mother
From reichman
130
biopsychosocial model proposed by
George engel
