Fractures Flashcards
What inflammatory mediators are released following a fracture?
Interleukins 1 and 6 (attract inflammatory cells)
BMP and FGF (cell differentiation and proliferation)
IFF-2 and TGF-B (lay down collagen matrix)
Where are the inflammatory mediators released from?
PLatelets
Describe the process of fracture healing
- Periosteal tear causes bleeding and a haematoma formation
- Fibroblasts enter and capillaries sprout into the haematoma
- Cytokine release causes granulation tissue to form
- Granulation tissue develops into a callus (adding type 2 collagen)
- Continued microfractures increase the size of the callus
- Callus is replaced by lamellar bone by osteoblasts and clasts
What factors help with remodelling of the callus?
Osteoclasts
Movement of surrounding tendons and muscles
Give some factors which affect bone healing
- Smoking
- NSAIDS
- Age
- Hormones
- Functional activity (movement aids osteogenesis)
- Nerve function
- Nutrition (Vit D deficiency)
- Local blood supply (periosteal stripping)
- Degree of immobilisation (more movement means greater blood supply)
- Local pathology
Define bone non-union
The permanent failure of healing following a broken bone
What are the different types of non-union?
Hypertrophic non-union
Atrophic non-union
Describe hypertrophic non-unopn
Callus forms but bony ends do not join together
- treat by rigidly immobilising fracture
Describe atrophic non-union
Callus does not form
- improve fixation
- expose raw ends of bone
- bone grafts
How can ultrasound be used in bone healing?
Causes micro-mechanical stress fractures which helps to induce callus formation
What are BMPs?
Bone Morphogenic Proteins
- Cytokines and metabologens which induce bone and cartilage development
- Can be produced with recombinant DNA technology to treat spinal fusions and fracture non-union
Define a fracture
A discontinuity in the bone cortex
Describe a transverse fracture
At riht angle to shaft
Due to side force
Describe an oblique fracture
At an oblique angle to shaft
Describe a spiral fracture
Curving or twisting along the bone
Describe a butterfly fracture
One fragment in the shape of a butterfly wing
Describe a comminuted fracture
More than two fragments
Describe an impacted fracture
One fragment has been driven into the other
Describe displaced fractures
The bone ends shift in relation to each other
Is described in relation to the distal fragment