Foundations of Psychiatry Flashcards
What are the 2 main ways psychiatric illnesses are stigmatized?
- not “real” disorders but are moral/spiritual weakness
- “unscientific” because it involves:
- subjective reporting of symptoms
- cultural context
What was the Feighner criteria from DSM3?
- clinical description of the syndrome
- lab studies
- delimitation from other disorders
- follow-up studies
- family studies
In DSM4, mental disorders are conceptualized as clinically significant behavioral or psychological syndromes that occur in individuals are are associated with what 3 things?
- present distress
- disability [impairment in area of functioning]
- important loss of freedom
To be diagnosed as a major depressive episode, what criteria must be met?
2 weeks with 5 or more of the following symptoms with one of which being ** :
- depressed mood *
- loss of interest/pleasure *
- weight loss or gain
- insomnia or hypersomnia
- psychomotor agitation or retardation
- fatigue and loss of energy
- worthlessness or excessive guilt
- diminished thinking/concentration
- recurrent thoughts of death, suicidal ideation
These must cause clinically significant distress and NOT be due to a substance, other medical condition or other psychological condition
What is the difference between reliability and validity?
Which is the DSM5 criteria?
Reliability- if 2 people see the same patient, they will arrive at the same diagnosis
Validity- actual and differentiated diseases
DSM criteria is reliable, but there is debate over the validity of the criteria due to the heterogeneity of symptoms lists and high rates of comorbid disorders
What are the 3 major benefits of the DSM?
What are the 2 major shortcomings?
Benefits:
- reliability
- critical to research
- gives clinicians a common language
Shortcomings:
- questionable validity due to:
- comorbid presentations
- heterogenous symptom lists - created by expert committees
- personal biases
- political pressures
What is the focus of RDoC?
Research Domain Criteria [RDoC] aims to relate core psychological processes to biological processes to provide a framework for defining boundaries of psychiatric disorders based on empirical data from:
- neuroscience [especially neural circuitry]
- genetics
What are the 5 domains associated with RDoC?
- Negative affect
- positive affect
- cognition
- social processes
- regulatory systems
Describe the negative affect domain.
What are the biologic correlates?
Negative affect is fear, distress and aggression.
- amygdala and hippocampus –> fear onset
- ventromedial prefrontal cortex –> fear response control
- circuits connecting to the prefrontal cortex–> extinction
What are the 3 features associated with positive affect domain?
What are the biologic correlates?
Positive affect is reward seeking/gratification, learning, habit forming.
- mesolimbic dopamine system
- orbital frontal cortex
- ventral and dorsal striatum
What 4 features are associated with cognition?
What area of the brain is associated with each?
- attention- parietal areas
- perception- thalamic and occipital
- memory:
- working = dorsolateral prefrontal cortex
- long term = hippocampus and prefrontal cortex - executive function - dorsolateral prefrontal cortex
What are the 3 main features of social processes?
What areas of the brain are associated with this?
Bonding, attachment, parenting and the related separation anxiety, facial recognition, etc.
Vasopressin and oxytocin systems play a role
What are the 3 main features of the regulatory systems domain of RDoC?
What areas of the brain are involved?
Arousal, sleep, circadian rhythm.
Reticular activating systems, ventral tegmental area, locus ceruleus
Psychiatric illnesses arise in the zone where what 3 things intersect?
- brain biology
- internal subjective experience [mind]
- cultural context
What is explanatory pluralism?
A theory by Kenneth Kendler that essentially says that there are an array of organizations which which to investigate a mental phenomena.
Ex. Depression
- genes for lack of resilience?
- neural circuits that regulate goals and rewards
- explanatory level of the mind [memories, regrets, longings, disappointments]