Formulation And Processing (non-steriles)

Question 1

What are the main steps in an oral solid dose process?

Answer 1

Milling
Blending
Granulation
Drying (optional)
Sizing
Post granulation blending
Compression or Encapsulation
Coating (optional)

Question 2

What is the purpose of Raw material dispensation

Answer 2

Accurate measurement of active ingredients and excipients

Question 3

What is the purpose of milling?

Answer 3

Reduction of particle size to achieve uniform granule size for better mixing and processing

Question 4

Mixing/Blending

Answer 4

Homogeneous mixing of APIs and excipients to ensure uniform distribution

Question 5

What are the three types of Granulation?

Answer 5

Wet granulation
Dry granulation
Direct compression

Question 6

What is the purpose of wet granulation?

Answer 6

Involves the addition of a liquid binder to form granules followed by drying

Question 7

What is the purpose of dry granulation?

Answer 7

It uses pressure to form granules without adding liquid

Question 8

What is the purpose of direct compression?

Answer 8

It bypasses granulation if the powder Helen’s exhibits good flow and compaction properties

Question 9

What is the purpose of drying following wet granulation?

Answer 9

It removes moisture to ensure stability and prevent microbial growth

Question 10

What is the purpose of sizing?

Answer 10

Involves the use of milling or screening to achieve the desired granule size distribution

Question 11

What is the purpose of compression?

Answer 11

Compresses granules into tablets of specific size and shape

Question 12

What is the purpose of encapsulation?

Answer 12

Fills granules or powder into capsules

Question 13

What is the purpose of tablet coating?

Answer 13

Applies a coating to tablets for stability, control release or to improve taste and appearance