Formative Quiz 1

Question 1

Which 2nd messenger does Adenylyl Cyclase activate?

Answer 1

cAMP

Question 2

Describe structure of GPCR in terms of protein domains

Answer 2

7 Transmembrane domains connected by 3 intracellular loops and 3 extracellular loops

N terminal on extracellular side when ligand binds, C terminal in cytoplasm where an additional helix domain allows G-protein to bind

Question 3

How many subunits make up P2X receptors?

Answer 3

3

Question 4

Which 3 stimuli cause platelet activation?

Answer 4

Basal Lamina
Thrombin
ADP

Question 5

Does Gs inhibit or stimulate adenylyl cyclase?

Answer 5

Stimulate

Question 6

Name a 2nd messenger activated by phospholipase C, is it membrane bound or cytoplasmic?

Answer 6

IP3 - Cytoplasmic
DAG - Membrane bound