Formative Flashcards
Antabuse - a drug used to treat alcoholism work by inhibiting
aldehyde dehydrogenase
Which microscopic features is NOT present within a portal tract?
Hepatocyte
Alcohol causes a diuresis because…
of decreased ADH levels
In a patient with alcoholic liver disease (ALD) presenting with an upper GI bleed, which biochemical test provides the most useful information about liver synthetic function?
prothrombin time
Which biochemical findings is commonly seen in patients with established alcoholic liver disease (ALD) (cirrhosis)?
Hyperbilirubinaemia, resulting in clinical jaundice.
What is not a recognized feature of dependence syndrome as per ICD-10?
narrowing of repertoire
The ligamentum teres within the falciform ligament is formed from which embryological structure?
umbilical vein
The liver enzyme AST is short for?
Aspartate aminotransferase
In the normal metabolic pathway the substance from which bilirubin is formed is…
biliverdin
According to the UK Chief Medical Officer, what is a safe limit on alcohol intake during pregnancy?
none - there is no safe limit
What does alcohol do to blood HDL levels?
increase
What drug leads to a faster rate of alcohol absorption?
domperidone
Facial flushing and a general feeling of being unwell is caused by…
aldehyde
In the process of death certification conditions listed under part 2 refer to…
conditions contributing to but not directly repsonsible for death
The abnormal gait seen in Wernicke’s syndrome is known as an…
Ataxic gait
The usual time scale for the development of Delerium Tremens is…
3-10 days
Which clotting factor is NOT made in the liver?
VIII
What is a useful screening tool for Alcohol Dependence Disorder?
AUDIT
According to the World Cancer Research Fund, for which of the following cancers is there strong evidence of an association with alcohol consumption?
BREAST
What is the definition of binge drinking for a man?
> 8 units in one day
What is not associated with acute pancreatitis?
Renal failure?
Acute pancreatitis is associated with
steroid use
A patient with LFTs showing a normal GGT, AST and ALT with high Alk Phos is most likely to have…
bone disease
Portal hypertension is most associated with…
Splenomegaly
If a patient has a raised osmolol gap what can they be treated with?
Ethanol
Fibrosis/cirrhosis of the liver is mediated by which type of cell?
interstitial cells of Ito
Severe hepatitis is associated with…
Hepatorenal syndrome
In a severe GI bleed what biochemical test can be used?
Serum lactate
Jaundice as a result of alcohol hepatitis is caused by an accumulation of…
conjugated bilirubin
How many unuts are in 1l bottle of cider (strength 8%)?
8
Microscopically, hepatocytes are bordered by…
the space of DIsse
Which of these medications is used for Medically Assisted Alcohol Withdrawal?
Chlordiazepoxide
