Formative

Question 1

Antabuse - a drug used to treat alcoholism work by inhibiting

Answer 1

aldehyde dehydrogenase

Question 2

Which microscopic features is NOT present within a portal tract?

Answer 2

Hepatocyte

Question 3

Alcohol causes a diuresis because…

Answer 3

of decreased ADH levels

Question 4

In a patient with alcoholic liver disease (ALD) presenting with an upper GI bleed, which biochemical test provides the most useful information about liver synthetic function?

Answer 4

prothrombin time

Question 5

Which biochemical findings is commonly seen in patients with established alcoholic liver disease (ALD) (cirrhosis)?

Answer 5

Hyperbilirubinaemia, resulting in clinical jaundice.

Question 6

What is not a recognized feature of dependence syndrome as per ICD-10?

Answer 6

narrowing of repertoire

Question 7

The ligamentum teres within the falciform ligament is formed from which embryological structure?

Answer 7

umbilical vein

Question 8

The liver enzyme AST is short for?

Answer 8

Aspartate aminotransferase

Question 9

In the normal metabolic pathway the substance from which bilirubin is formed is…

Answer 9

biliverdin

Question 10

According to the UK Chief Medical Officer, what is a safe limit on alcohol intake during pregnancy?

Answer 10

none - there is no safe limit

Question 11

What does alcohol do to blood HDL levels?

Answer 11

increase

Question 12

What drug leads to a faster rate of alcohol absorption?

Answer 12

domperidone

Question 13

Facial flushing and a general feeling of being unwell is caused by…

Answer 13

aldehyde

Question 14

In the process of death certification conditions listed under part 2 refer to…

Answer 14

conditions contributing to but not directly repsonsible for death

Question 15

The abnormal gait seen in Wernicke’s syndrome is known as an…

Answer 15

Ataxic gait

Question 16

The usual time scale for the development of Delerium Tremens is…

Answer 16

3-10 days

Question 17

Which clotting factor is NOT made in the liver?

Answer 17

VIII

Question 18

What is a useful screening tool for Alcohol Dependence Disorder?

Answer 18

AUDIT

Question 19

According to the World Cancer Research Fund, for which of the following cancers is there strong evidence of an association with alcohol consumption?

Answer 19

BREAST

Question 20

What is the definition of binge drinking for a man?

Answer 20

> 8 units in one day

Question 21

What is not associated with acute pancreatitis?

Answer 21

Renal failure?

Question 22

Acute pancreatitis is associated with

Answer 22

steroid use

Question 23

A patient with LFTs showing a normal GGT, AST and ALT with high Alk Phos is most likely to have…

Answer 23

bone disease

Question 24

Portal hypertension is most associated with…

Answer 24

Splenomegaly

Question 25

If a patient has a raised osmolol gap what can they be treated with?

Answer 25

Ethanol

Question 26

Fibrosis/cirrhosis of the liver is mediated by which type of cell?

Answer 26

interstitial cells of Ito

Question 27

Severe hepatitis is associated with…

Answer 27

Hepatorenal syndrome

Question 28

In a severe GI bleed what biochemical test can be used?

Answer 28

Serum lactate

Question 29

Jaundice as a result of alcohol hepatitis is caused by an accumulation of…

Answer 29

conjugated bilirubin

Question 30

How many unuts are in 1l bottle of cider (strength 8%)?

Answer 30

8

Question 31

Microscopically, hepatocytes are bordered by…

Answer 31

the space of DIsse

Question 32

Which of these medications is used for Medically Assisted Alcohol Withdrawal?

Answer 32

Chlordiazepoxide