Forensic DNA database Flashcards

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1
Q

What is CODIS?

A

Combined DNA Index System

CODIS is the FBI’s program of support for criminal justice DNA databases as well as the software used to run these databases.

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2
Q

How many core loci underly CODIS and how many population datasets are included?

A

13 core loci

over 50 population databases; more than 10 000 individuals

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3
Q

What does YHRD stand for?

A

Y-STR Haplotype Reference Database

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4
Q

How many core loci are defined by SWGDAM for Y-STR analysis?

A

11

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5
Q

SWGDAM recommendations for mtDNA typing

A
  • GLP and follow specific protocols
  • Negative and positive controls and extraction reagent blanks
  • reported sequences must be based on redundant information from forward and reverse primers
  • manual transcription should be avoided
  • independent confirmation by two scientists
  • labs shall participate in proficiency testing programs
  • sequence entire mitochondrial DNA control region in population genetic studies
  • report relative to rCRS, allignment needed
  • use IUPAC convention
  • use analytical software that checks for phylogenetics
  • be able to justify choice of database and statistical approach
  • establish statistical guidelines for reporting match between two samples
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6
Q

SWGDAM recommendations for mtDNA heteroplasmy

A
  • labs have to establish their own guidelines on how do deal with them
  • “differences in both PHP and LHP do not constitute evidence for excluding two otherwise identical haplotypes as deriving from the same source or same maternal lineage”
  • put the dominant variant into database
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