Follow-up/Toxicity

Question 1

What are some common late toxicities that manifest after the Tx of skull base chordomas?

Answer 1

∼26% of skull base chordoma pts develop endocrine abnormalities, while 5%–10% of pts develop vision loss, brainstem injury, or temporal lobe injury in 2–5 yrs. (Berson AM et al., IJROBP 1988; Santoni R et al., IJROBP 1998) The risk for sacral neuropathy increases with doses ≥76.6 Gy. (Delaney TF et al., J Surg Oncol 2014)