Follow-up/Surveillance

Question 1

What is the recommended radiographic f/u?

Answer 1

MRI q3 mos for 2 yrs, q6 mos for yrs 2–5, then annually (NCCN 2018)

Question 2

What was the toxicity rate in the RTOG 93–10 study?

Answer 2

RTOG 93–10: 15% had severe delayed neurotoxicity (especially if >60 yo). (DeAngelis LM et al., JCO 2002)

Question 3

What was the Tx-related mortality for pts treated with chemo alone in the German trials?

Answer 3

In German trials, Tx-related mortality with chemo alone was 9%. PCNSL: results of a pilot and phase II study of systemic and intraventricular chemo with deferred radiotherapy. (Pels H et al., JCO 2003)