Folic Acid Synthesis Inhibitors

Question 1

Which class of drugs inhibit Dihydropteroate synthase (conversion of PABA+Pteridine to Dihydropteroic acid)? Name them (3)

Answer 1

Sulfonamides; Sulfamethoxazole, sulfoxazole, sulfadiazine

Question 2

Which drug inhibits Dihydrofolate reductase?

Answer 2

Trimethoprim