FNP Pharm Review (Leik book) Flashcards
Name 7 narrow therapeutic index drugs
Warfarin Digoxin Theophylline Tegretol Dilantin Levothyroxine Lithium
What drug interferes with garlic, ginger, gingko, ginseng?
Warfarin
What glitazone causes or worsens CHF? Side effects of this med?
Pioglitazone (Actos)
edema, weight gain, cough
Name 3 atypical antipsychotics. What are risks or side effects with these meds?
Risperidone, Olanzapine (Zyprexa), Quetiapine.
weight gain, increased BMI, DM2, hyperlipidemia
How should biphosphonates be taken?
Take before meal, with water (no juice, no other drugs)
Side effects of statins?
drug induced hepatitis, rhabdomyolysis if mixed with -azoles
Name a common lincosamide, and its common side effect
Clindamycin- risk for C diff colitis (give Flagyl & probiotics)
Why is digoxin given?
Sx of overdose?
SV arrythmias, heart failure, LV systolic dysfunction.
OD= n/v/abd pain, arrythmias, confusion, vision change (yellow-green), scotomas
What is the maximum time a pt can take Ketorolac?
5 days
Why shouldn’t you combine ACEI & ARBs with K-sparing diuretics?
risk of hyperkalemia
What is a side effect of Spironolactone?
Gynecomastia, galactorrhea
Name some phosphodiesterase inhibitors.
What should NOT be taken with these drugs?
Sildenafil (viagra),; Tadalafil (Cialis), Vardenafil (Levitra)
- do not mix w/ nitrates, some alpha blockers
- if erection sustained >4 hours, go to ED
- don’t give within 3-6 months of MI or stroke
Patient is on coumadin, and INR is 5. What should he do with dosing?
INR 5= omit one dose, check INR
What are foods w/ Vitamin K? What do they do to the INR with pt on coumadin?
green leafy veggies (kale, spinach, collard greens, broccoli). These reduce warfarin’s effect, and decrease INR.
Which diuretics contain sulfa?
Thiazide (HCTZ, Chlorthalidone, Indapamide) & loop (lasix, bumex).
If allergic to sulfa but needs a diuretic, what to prescribe?
K-sparing (triamterene or Amiloride)
Side effects of thiazide diuretics?
- Glucosuria, hyperuricemia, high cholesterol & LDL
- hypokalemia (arrythmias)
Antihypertensives that are ok to give in pregnancy?
methyldopa, beta blockers
What antihypertensives are NOT ok to give in pregnancy?
ACEI
ARBs
Contraindications for calcium channel blockers?
2nd & 3rd degree heart blocks, CHF, bradycardia