Fluroquinolones

Question 1

2nd generation fluroquinolones (gram-cocci)

Answer 1

Ciprofloxacin, ofloxacin
* pseudomonas
* atypical pneumonias. H.influenza, M catarrhalis

Question 2

3rd generation fluroquinolones (gram + cocci)

Answer 2

Levoflxacin, moxifloxacin, gemifloxacin

*streptococci, MRSA

Question 3

Pharmacokinetics

Answer 3

Oral
Antacid and food may interfere
Probenecid may block excretion.
Reduce dose in renal dysfunction.

Moxifloxacin: hepatic and biliary metabolism
Dont give in UTI

Question 4

MOA

Answer 4

Inhibits topoisomerase 2+4
Block relaxation of DNA

POST ANTIBIOTIC EFFECT
BACTERICIDAL

Question 5

Toxicity

Answer 5

GIT distress
Rash, headache, dizziness,insomnia
Abnormal LFTs, tendinitis, tendon rupture

Dont give to children and pregnant

Increases level of theophylline and methyxanthines
Prolong QT
Dont give wd anti arrhythmia