Fluids and Electrolytes Flashcards
Fluid Balance
Total body water
Composed of:
Intracellular fluid: 67%
Interstitial fluid: 25%
Plasma volume: 8%
———-
60% of adult human body is water.
Intravascular fluid
Fluid inside blood vessels
Extravascular fluid
Fluid outside blood vessels
Lymph, cerebrospinal fluid
Extravascular volume
Plasma
Interstitial fluid: fluid in space between cells, tissues, and organs
Extracellular volume
Interstitial fluid
Intracellular fluid
Plasma proteins exert constant osmotic pressure.
Colloid oncotic pressure
Normally 24 mm Hg
Interstitial fluid exerts hydrostatic pressure.
Normally 17 mm Hg
Edema
Dehydration and fluid loss
Acid–base balance
Sodium is principal extracellular electrolyte, playing a major role in maintaining water concentration
Distribution of Total Body Water
TBW- 60% is water
ECF- 1/3
PV- 1/3
ISF- 2/3
ICF- 2/3
Hypertonic
H20 goes outside the cell
Isotonic
H20 in and out of the cell is balanced
Hypotonic
H20 goes inside the cell
Crystalloids
Solutions containing fluids and electrolytes that are normally found in the body
Do not contain proteins (colloids)
No risk for viral transmission, anaphylaxis, or alteration in coagulation profile
Better for treating dehydration rather than expanding plasma volume
Crystalloids is used as maintenance fluids to:
Compensate for insensible fluid losses
Replace fluids
Manage specific fluid and electrolyte disturbances
Promote urinary flow
7 Crystalloids solutions
Normal saline (NS): 0.9% sodium chloride is isotonic; 0.45% “half-normal” is hypotonic)
3.3% dextrose and 0.3% NS (two thirds and one third) (isotonic)
Hypertonic saline (3% sodium chloride)
Lactated Ringer’s solution (isotonic)
Dextrose 5% in water (D5W) (isotonic)
D5W and 0.45% NS (hypertonic)
Plasma-Lyte (isotonic)
Crystalloids indications
Acute liver failure
Acute nephrosis
Adult respiratory distress syndrome
Burns
Cardiopulmonary bypass
Hypoproteinemia
Hemodialysis
Deep vein thrombosis (reduction of risk)
Shock
Crystalloids Adverse effects
May cause edema, especially peripheral or pulmonary
May dilute plasma proteins, reducing colloid oncotic pressure
Effects may be short-lived
Prolonged infusions may worsen alkalosis or acidosis
Colloids
Protein substances
Increase colloid oncotic pressure
Move fluid from interstitial compartment to plasma compartment (when plasma protein levels are low)
3 Colloids
Albumin 5% and 25% (from human donors)
Dextran 40 or 70 (available in sodium chloride and 5% dextrose)
Hetastarch (synthetic)
Colloids Adverse effects
Usually safe
May cause altered coagulation, resulting in bleeding
Have no clotting factors or oxygen-carrying capacity
Rarely, dextran therapy causes anaphylaxis or kidney failure.
Colloids: Albumin
Natural protein that is normally produced by the liver
Responsible for generating approximately 70% of colloid oncotic pressure
Sterile solution of serum albumin that is prepared from pooled blood, plasma, serum, or placentas obtained from healthy human donors
Pasteurized to destroy any contaminants
Blood Products
The only class of fluids that are able to carry oxygen
Increase tissue oxygenation
Increase plasma volume
Increase colloid osmotic pressure and plasma volume
-Pull fluid from extravascular space into intravascular space (plasma expanders)
-Red blood cell products also carry oxygen.
Blood products facts
Most expensive and least available fluid because they require human donors
Derived from human donors and thus have all the benefits (and hazards) of human blood products
Blood Products Indications
Cryoprecipitate and plasma protein factors
Management of acute bleeding (greater than 50% slow blood loss or 20% acutely)