Fluid And Electrolyte Imbalance - Ketoacidosis Flashcards

1
Q

DKA results from

A

Combination of insulin deficiency and an increase in counterregulatory hormone release

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2
Q

Most common precipitating factor of DKA

A

Infection

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3
Q

Mortality is highest for those who also have

A

Infection, stroke, MI, vascular thrombosis, intestinal obstruction, or pneumonia

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4
Q

Hyperglycemia leads to

A

Osmotic diuresis with dehydration and electrolyte loss

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5
Q

Symptoms of DKA

A
Polyuria,
Polydipsia,
Polyphagia, 
Weight loss, 
Vomiting,
Abdominal pain, 
Dehydration, 
Altered mental status, 
Shock, 
Coma
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6
Q

Mental status

A

Total alertness to profound coma

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7
Q

As keytone levels rise,

A

The buffering capacity of the body is exceeded, blood pH decreases, and acidosis occurs

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8
Q

Kussmaul respirations cause

A

Respiratory alkalosis in attempt to correct metabolic acidosis by exhaling CO2; rapid and deep respiratory pattern

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9
Q

DKA onset

A

Sudden

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10
Q

DKA precipitating factors

A

Infection, other stressors, and inadequate insulin dose

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11
Q

DKA manifestations

A

Ketosis (fruity breath, nausea, abdominal pain), dehydration or electrolyte loss (polyuria, polydipsia, weight loss, dry skin, sunken eyes, soft eyeballs, lethargy, coma)

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12
Q

Serum glucose in DKA

A

> 300 mg/dL

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13
Q

Osmolarity in DKA

A

Variable

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14
Q

Serum keytones in DKA

A

Positive at 1:2 dilutions

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15
Q

Serum pH in DKA

A
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16
Q

Serum HCO3 in DKA

A
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17
Q

Serum Na in DKA

A

Low, normal, or high

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18
Q

BUN in DKA

A

> 30 mg/dL (elevated d/t dehydration)

19
Q

Creatinine in DKA

A

> 1.5 mg/dL (elevated d/t dehydration)

20
Q

Urine keytones in DKA

21
Q

Priority assessment for DKA

A

Airway, LOC, hydration status, electrolytes, and blood glucose level

22
Q

Monitor every 15 minutes until stable

A

BP, pulse, respirations

23
Q

Monitor hourly

A

Urine output, temp, mental status

24
Q

Every 30 minutes

A

Central venous pressure if central venous catheter is present

25
Kidneys are less able to respond to
Changes in pH or fluid and electrolyte balance, to concentrate urine, or to regulate blood osmolarity
26
First outcome of fluid therapy
Restore volume and maintain perfusion to the brain, heart, and kidneys; use rate of 15-20 mL/kg during the first hour
27
Second outcome of fluid therapy
Replacing the total body fluid losses; typically hypotonic fluid infused at 4-14 mL/kg/hr after initial fluid bolus
28
Prevent hypoglycemia and cerebral edema during treatment
When blood glucose levels = 250mg/dL, give 5% dextrose in 0.45% saline
29
First 24 hrs of treatment
Pt needs fluid to replace deficit and ongoing loss (maybe 6-10 L); assess cardiac, kidney, and mental status to avoid fluid overload; watch for signs of congestive heart failure and pulmonary edema
30
Assess fluid status
Monitor BP and I and O
31
Treatment of choice to lower blood glucose by 50-75 mg/dL/hr
Regular insulin by IV infusion; IV bolus 0.1 unit/kg followed by 0.1 unit/kg/hr
32
IV insulin
4-minute half-life
33
Subcutaneous insulin
Started when pt can take oral fluids and ketones has stopped; delayed onset of action and prolonged half-life when compared to IV insulin
34
Resolution of DKA
Blood glucose 18 mEq/L; venous pH >7.3; calculated ion gap
35
DKA is characterized by
Uncontrolled hyperglycemia, metabolic acidosis, and increased production of keystones
36
No Kidding Insulin Always Helps
``` N - NS; K - potassium; I - insulin; A - abx; H - HCO3 ```
37
Which electrolyte is most effected by hyperglycemia?
Potassium
38
What type of insulin is used in the emergency treatment of DKA?
Regular insulin via IV
39
Pt admitted with BG of 900 and 2 hrs after treatment initiation with IV insulin, it is 400. What complication is pt at risk for?
Hypoglycemia: BS should only come down 50-75/hour
40
Hypertonic
Pulls fluid out of the cells; cells shrink; will administer for DKA after BS reaches >250 mg/dL; D5 0.45%NS
41
Hypotonic
Cells swell; pulls fluid into cells; D5W, 0.45%NS
42
Isotonic
"I'm so perfect"; keeps cells just the way they are; use for maintenance fluid; 0.9%NS, LR
43
Regulate glucose on a sick day
FSBS Q4h; test urine for ketones if FSBS>240; continue insulin; 8-12 oz fluid/hr; eat at regular times; rest; treat symptoms; BRAT diet; ondansetron PRN; notify provider for danger signs
44
Danger signs on sick day
Persistent N/V; moderate or large keytones; increased FSBS after 2 doses of insulin; elevated temp