Fluid And Electrolyte Flashcards

1
Q

Intracellular and Extracellular Fluid

A

2/3 is intracellular 1/3 is extracellular
Intracellular = potassium, magnesium (small amounts of sodium, chloride, bicarbonate, phosphate)
Extracellular = sodium and chloride (small amounts of bicarbonate, phosphate, calcium, magnesium, and potassium)
ICF and ECF always have equal amounts of cations and anions

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2
Q

Edema: mechanisms of formation

A

I. Increase in capillary filtration pressure
Increased vascular volume - HF, kidney disease, IV overload
Venous obstruction - thrombophlebitis
Liver disease - portal vein obstruction
Acute pulmonary edema
Dependent edema

  1. Decrease in capillary colloidal osmotic pressure
    Increased loss of plasma proteins - burns, kidney disease
    Decreased production of plasma proteins - liver disease, malnutrition
    General edema
  2. Increase in capillary permeability
    Inflammation, allergic reactions, malignancy, ascites, pleural effusion, tissue injury, burns
    Localized non pitting
  3. Produce an obstruction of lymph flow
    Malignant obstruction, surgery
    Localized to area of impaired drainage
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3
Q

Edema: manifestations

A

Edema to brain, larynx, lungs, pericardial, pleural, peritoneum = life threatening

Joint spaces, coccyx, ankles, feet = discomfort, impaired rom

Tourniquet - blood vessel compression
Pressure ulcers - further for nutrients to diffuse
Psychological self concept

Non pitting edema = proteins accumulated in tissues and coagulated

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4
Q

Edema: Treatment

A

elevation - counter gravity
Diuretic therapy - decrease fluid volume
Massage - promote lymphatic and vascular return
ROM - lymphatic and venous return
Serum albumin - given to IV to raise colloid plasma oncotic
Elastic support stockings - oppose fluid movement

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5
Q

Third Space Accumulations

A

Loss or movement and trapping of ECF in trans compartment all spaces (serous, pericardial, peritoneal, pleural)
Cavities are often closely linked with lymphatic drainage

Milking action of moving structures (lungs) moves fluid and proteins back into lymphatic channels

Gain in body weight doesn’t contribute to fluid reserve or function

Hydrothorax - edema in the pleural cavity
Ascites - fluid in peritoneal cavity due to liver failure
Effusion - transmutation of fluid into serous cavities

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6
Q

Water gain and water loss

A

Positive water balance = decreased osmolality and sodium
Negative water balance = increased osmolality and sodium

Gain - intake, metabolic processes
Loss - kidney, skin (insensible loss), lungs (insensible loss), GI

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7
Q

Water Regulation

A

Aldosterone - increased sodium reabsorption and potassium excretion = increased blood volume
Renin, stress, trauma,
ADH - increases sodium reabsorption, aquaporins = increased blood volume
ECF volume and osmolality
Renin - angiotensin II = increased aldosterone, and sodium reabsorption = increased blood volume
Blood pressure low

Thirst and ADH regulate water intake and output

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8
Q

Sodium Regulation

A

Sympathetic Nervous System: changes in arterial blood pressure = adjust in GFR and sodium reabsorption

RAAS - increase sodium reabsorption and vasoconstriction

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9
Q

Thirst control

A

High osmolality = thirst and ADH release
Low osmolality = lack of thirst and decreased ADH release

Cellular dehydration (osmolality) and decrease in circulating volume (stretch receptors) stimulates hypothalamus to thirst and production of angiotensin II (nonosmotic thirst; back up)

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10
Q

Hypodipsia and Polydipsia

A

Decreased ability to sense thirst
Commonly associated with lesions in the area of the hypothalamus (trauma, hemorrhage, meningiomas)

Excessive thirst
Inappropriate or false thirst - despite normal body water; CHF, chronic kidney disease
Compulsive water drinking - schizophrenia, smoking

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11
Q

Diabetes Insipidus: Causes

A

Deficiency in ADH or a decreased renal response to ADH
Expelling large amounts of urine and excessive thirst
Danger arises when pt is unable to communicate need for water or unable to secure water

Neurogenic DI - deficit in synthesis or release of ADH
Inflammatory, autoimmune, vascular disease
Many have an incomplete form

Nephrotic DI - kidneys do not response to ADH
Congenital, pyelonephritis, lithium toxicity, electrolyte disorders

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12
Q

Diabetes Insipidus: Manifestations

A
Intense thirst
Craving ice water
Polyuria
Reduced fluid volume
Polydipsia
Hypernatremia
Dehydration
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13
Q

Syndrome of Inappropriate Antidiuretic Hormone: Causes

A

Failure of negative feedback system regulating ADH leading to water retention
Dilutional hyponatremia

Surgery, pain, stress, temperature changes, drugs, lung tumours, chest lesions, CNS disorders,
Tumors
Intrathoracic conditions - TB, pneumonia, positive pressure breathing

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14
Q

SIADH: manifestations

A

Dilutional hyponatremia
Decreased urine output
Urine osmolality high
Hematocrit, serum sodium, BUN, decreased

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15
Q

Isotonic Fluid Volume Deficit: Causes

A

Water and electrolytes lost in isotonic proportions

Severe vomiting
Diarrhea
GI suction
Excess urinary loss
Excess sweating
Endocrine disorders - adrenal insufficiency
3rd space losses
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16
Q

Isotonic Fluid Volume Deficit: Manifestations

A
Decreased body weight
Thirst
Oliguria
Urine gravity increases 
Eyes look sunken
Tissue turgor decreases
BP decrease, HR increase, weak pulses
Postural hypotension

Hypovolemic shock
Vascular collapse

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17
Q

Isotonic Fluid Volume Deficit: Treatment

A

Fluid replacement and measures to correct underlying cause

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18
Q

Isotonic Fluid Volume Excess: Causes

A

Isotonic expansion of ECF - increase in total body sodium and body water

Excess intake of sodium
Heart failure - compensatory increase
Liver failure - impaired aldosterone metabolism
Corticosteroid hormone excess - increased reabsorption of sodium
Circulatory overload

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19
Q

Isotonic Fluid Volume Excess: Manifestations

A
Weight gain
Dependent edema
Distended neck veins
Slow emptying peripheral veins
Full bounding pulse
Increased central venous pressures
Fluid accumulation in lungs - SOB, dyspnea, crackles, productive cough

Ascites
Pleural effusion

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20
Q

Isotonic Fluid Volume Excess: Treatment

A

Sodium restricted diet

Diuretics

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21
Q

Hyponatremia: Causes

A

Serum sodium below 135
Most common disorder

Hypertonic hyponatremia - hyperglycemia
Hypovolemic hypotonic hyponatremia - excessive sweating, GI fluid loss, adrenal insufficiency
Euvolemic hypotonic hyponatremia - SIADH
Hypervolemic hypotonic hyponatremia - HF, liver disease, renal failure, MDMA abuse

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22
Q

Hyponatremia: Manifestations

A
Muscle cramps
Weakness
Fatigue
Nausea and vomiting
Abdominal cramps
Diarrhea
Apathy
Lethargy
Headache
Disorientation
Confusion
Depression of deep tendon reflexes
Seizure and coma 
Weakness
23
Q

Hyponatremia: treatment

A

Discontinue SIADH medication
IV or oral saline solution (hypertonic)
Loop diuretics
Vasopressin receptor antagonist

24
Q

Hypernatremia: Causes

A

Sodium above 145

Water loss through GI, urine, lungs, skin
Ingestion
IV sodium
Hypodipsia

25
Hypernatremia: Manifestations
``` Thirst Tachycardia Decreased urine output Fever Flush warm skin Dry skin and mucous membranes Decreased salivation and lacrimation Decreased reflexes Agitation Headache Restlessness Seizure Coma ```
26
Hypernatremia: treatment
Limit intake | Replace fluid oral or IV D5W
27
Values of Co2, Bicarbonate, and pH
CO2 >50 = acidosis CO2 <35 = alkalosis PH <7.35 = acidosis PH >7.45 = alkalosis Bicarbonate <22 = acidosis Bicarbonate >36 = alkalosis Ph serum levels are not directly proportionate to CO2 levels Arterial blood gases - indicate respiratory and metabolic function
28
Potassium Regulation
Intake oral urine output (aldosterone eliminates and hydrogen reabsorption eliminates) transcompartmental shifts in ICF and ECF Serum osmolality - water moves out of cell into ECF = increase in potassium concentration Acid base balance - cation shift for buffering pH = (alkalosis = hydrogen excreted; hypokalemia and acidosis = hydrogen reabsorbed; hyperkalemia) Insulin - temporary shift into cells; hypokalemia Sympathetic NS - epinephrine = increase in uptake; hypokalemia
29
Hypokalemia: Causes
Serum potassium below 3.5 Inadequate intake - low potassium diet or inability to obtain or ingest food Burns and capillary injury Excessive renal losses - diuretic, alkalosis, magnesium depletion, increased aldosterone Insulin Beta adrenergic agonist drugs
30
Hypokalemia: manifestations
``` Increased urine output - polyuria Nocturia Thirst Anorexia Nausea and vomiting Constipation Weakness Fatigue Muscle cramps ECG changes Arrhythmias and digitalis toxicity Alkalosis and renal chloride wasting ```
31
Hypokalemia: treatment
Increasing intake Oral supplement IV potassium and magnesium replacement
32
Hyperkalemia: causes
Potassium above 5 Decreased renal elimination - chronic kidney disease, nephropathy, aldosterone deficiency, potassium sparing diuretics, ace inhibitors Shift from ICF to ECF - acidosis, tissue injury, decreased insulin, beta blockers Increased intake
33
Hyperkalemia: manifestations
``` Bradycardia Cardiac arrests ECG changes Weakness Paralysis Paresthesia Cramps Diarrhea Nausea and vomiting ```
34
Hyperkalemia: treatment
``` Calcium Sodium bicarbonate Beta agonists Insulin Hemodialysis or peritoneal dialysis Restrict intake ```
35
Hypocalcemia: causes
Below 8.5 ``` Decreased intake Renal failure Hypoparathyroidism Vitamin D deficiency Respiratory alkalosis Loop diuretic PPI H2 blockers Citrate ```
36
Hypocalcemia: manifestations
``` Tetany Bone pain Carpopedal spasm Trousseau sign Chvoskek sign Twitching facial muscle Parestheisa Confusion Lethargy Anxiety Cardiac arrhythmia Resistance to digitalis Hypotension ```
37
Hypercalcemia: Causes
Above 10.5 ``` Neoplasms of the parathyroid gland Hyperparathyroidism Immobilization Increased absorption in intestine Excess vitamin D Lithium Thiazide drugs ```
38
Hypercalcemia: manifestations
``` Muscle weakness Lethargy Ataxia Personality changes Stupor Coma HTN ECG changes Anorexia Nausea and vomiting Constipation Thirst and dilute urine ```
39
Carbon Dioxide Transport
Bicarbonate - plasma RBC, CA converts CO2 and H20 into H2CO3 that dissociates into H and HCO3 (bicarbonate) where HC03 is exchanged for Cl- Hemoglobin - combination of C02 and Hgb loose reversible for exchange in lungs Plasma - dissolved in plasma that forms carbonic acid from hydration of dissolved CO2
40
Mechanisms of pH regulation
Chemical buffer - bicarbonate (weak acid H2C03 and weak base NaHC03) AND potassium hydrogen exchange AND body proteins Bone buffering - leading to demineralization Respiratory - ventilation to increase CO2 exchange; monitored by chemoreceptors in brain, carotid, and aortic bodies Renal - reabsorption of HCO3 and Regulation of H+ secretion and generation of new bicarbonate; phosphate buffer system
41
Primary and Secondary in Mixed acid base disorders
Value furthest from norm is primary | If values of predicted compensatory values fall outside range it is mixed
42
Metabolic Acidosis: causes
Increasing respiratory rate HCO3 <22 and pH <7.35 Lactic acid buildup and production of ketoacids Inadequate o2 deliver - shock, cardiac arrest, intense exercise, cancers, liver failure Poorly controlled diabetes Kidney disease Diarrhea
43
Metabolic Acidosis: manifestations
``` Lethargy Stupor Fatigue and malaise Kussmauls respirations Hyperventilation Hypotension Arrhythmia Tachycardia Anorexia Nausea and vomiting Abdominal pain ```
44
Metabolic Acidosis: treatment
Correcting underlying cause Restoring lost fluid and electrolytes Insulin and fluid replacement in diabetic ketosis
45
Metabolic Alkalosis: causes
Hypoventilation HCO3 >26 ph >7.45 ``` Vomiting Gastric suctioning Ingestion of alkali - calcium carbonate, antacids IV bicarbonate Hyperaldosteronism Diuretics Abrupt acidosis correction ```
46
Metabolic Alkalosis: manifestations
``` Hyperactive reflexes Tetany Confusion Seizures Carpopedal spasm Trosseau signs Bradypnea Shallow respirations Hypoxemia Respiratory acidosis Hypotension Arrhythmia Nausea and vomiting ```
47
Metabolic Alkalosis: treatment
Correcting underlying cause | Chloride Deficit requires correction (potassium chloride)
48
Respiratory Acidosis: causes
Renal adaptation PaCO2 >45 pH <7.35 ``` Acute respiratory failure Narcotic overdose Lung disease Chest injury or obstruction Pneumothorax Enervation COPD Timor Exercise Fever - Hyperthermia Sepsis Burns Carbohydrate rich diet Accidental inspiration of CO2 ```
49
Respiratory acidosis: manifestations
``` Restlessness Confusion Depressed reflexes Somnolence Coma Blurred vision Psychological disturbances Dyspnea Tachypnea Hypoxemia Tachycardia Arrhythmia HTN or Hypotension Warm flush skin and weakness ```
50
Respiratory acidosis: treatment
Improve ventilation | Mechanical ventilation
51
Respiratory alkalosis: causes
Hydrogen pulled from cells to produce carbonic acid PaCO2 <35 and pH >7.45 Hyperventilation Medullary stimulation Mechanical ventilation Disease processes
52
Respiratory alkalosis: manifestations
``` Dizzzy, Agitated Circumoral and peripheral paresthsia Tetany Twitching Muscle weakness Light headed Deep rapid respirations Dyspnea Palpitations Tachycardia ```
53
Respiratory alkalosis: treatment
Correct underlying cause Rebreathe into a paper bag Supplemental o2 and changing ventilator settings