Fisiopatologia

Question 1

Clostridium difficile is an

Answer 1

anaerobic gram-positive, spore-forming, toxin-producing bacillus

Question 2

is transmitted

Answer 2

among humans through the fecal– oral route

Question 3

C. difficile colonizes

Answer 3

the large intestine

Question 4

C. difficile Releases

Answer 4

two protein exotoxins (TcdA and TcdB) that cause colitis in susceptible persons

Question 5

Infection is transmitted by

Answer 5

spores that are resistant to heat, acid, and antibiotics

Question 6

C. difficile diarrhea is mediated by

Answer 6

TcdA and TcdB, which inactivate members of the Rho family of guanosine triphosphatases (Rho GTPases), leading to colonocyte death, loss of intestinal barrier function, and neutrophilic colitis. The organism itself is noninvasive, and infection outside the colon is extremely rare