Fisher Investments Flashcards

1
Q

What is the Beta vs the S&P 500 of the Healthcare Sector?

A

Around .7, the lowest of all industry verticals

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2
Q

What is a “managed health” company?

A

A health insurance firm

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3
Q

What are the two broad GICS groups for Health Care?

A

(i) pharmaceuticals, biotechnology & life sciences (anything related to prescription drugs but not pharmacy benefit managers and ~75% of entire sector) and
(ii) Health Care and Equipment Services - med device/health insurance/ hospitals /etc

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4
Q

What % of the All Country World Index does Healthcare account for?

A

Around 9-10%

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5
Q

What are the 5 general characteristics of Healthcare equities?

A

1- less economically sensitive and less volatile than broad market due to inelastic product demand
2-heavy government involvement
3-large, global market
4-mostly characterized by big cap, growth companies
5-dominated by US firms

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6
Q

What are the two general reasons for why Healthcare costs so much in the United States?

A

(1) demand for services exceeds supply of services

(2) the US system is massively inefficient

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7
Q

What are the 5 primary demand drivers of the US Healthcare consumption?

A

(1) imperfect information - patients don’t know cost of products/services since its usually paid for by someone else
(2) Asymmetry - providers have far more knowledge of products/pricing than customers, leading to incentives to sell more products than necessary
(3) preventable diseases - caused by smoking/obesity
(4) defensive medicine - running excessive tests to limit legal liability
(5) external demand - selling to foreign governments comes with price caps leading US patients to get overcharged

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8
Q

What is a “managed care plan”?

A

Insurance plan that tries to manage health costs by arranging a network of health providers at discounted rates in exchange for giving providers a larger customer base (Medicare and private plans with copay are an example)

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9
Q

What is an HMO?

A

Health Maintenance Organization - A private insurance plan where a patient selects a primary care physician from a designated network and that doctor can then refer a patient to a specialist. Out of network physicans are generally not covered. Co-pays for services are made
-Least expensive plans and have capitated contracts with providers

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10
Q

What is a capitated contract?

A

An agreement between an insurer and providers, under which they pay a fixed monthly fee for services, regardless of how often a patient sees a doctor
-a feature of an HMO

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11
Q

What is a PPO?

A

Preferred Provider Organization - A private insurance plan where members can select doctors in or out of network, but fees are higher for out-of-network doctors.
-no co-pays; have a $ deductible and % coinsurance (PPO pays 80% going forward and patient pays 20% up to a stated maximum out of pocket expense)

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12
Q

What is a POS plan?

A

A hybrid of HMOs and PPOs where a network primary care physician is chosen as a point-of-service contact and the doctor may refer to the patient to out-of-network specialists (at higher fees to patients)

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13
Q

What is a Consumer Directed Plan?

A

A plan with a high initial deductible (a few thousand dollars) after which expenses are funded by the insurer
-high deductible makes insured have more skin in the game and can be funded with HSA

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14
Q

What is Medicare? How is it financed?

A
  • Medicare is a government health insurance program for disabled persons and people age 65 or over
  • It is financed by payroll taxes, general revenues, member premiums and taxes on social security benefits
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15
Q

What is CMS?

A

The Center for Medicare and Medicaid Services, which runs the programs

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16
Q

What is Medicaid? How is it financed?

A
  • Medicaid is a government health insurance program that provides benefits to low income people
  • its funded by general revenues from federal and state governments on an an as-needed basis but managed by the states
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17
Q

What is VHA?

A

The Veterans Health Administration

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18
Q

What is SCHIP?

A
  • The State Children’s Health Insurance Program

- provides coverage to uninsured children whose family incomes are not low enough to qualify for Medicaid

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19
Q

What is HHS?

A
  • The US Department of Health and Human Services

- responsible for health care regulation and providing health care to the less fortunate

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20
Q

What are the 4 primary types of U.S. private health insurance plans?

A
  • Health Maintenance Organization (HMO)
  • Preferred provider organization (PPO)
  • Point of Service
  • Consumer-directed plans
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21
Q

What does “universal health care coverage” loosely mean?

A

That all residents of a nation have access to health care coverage

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22
Q

What is a single payer system?

A

when the government pays for health care whether it’s delivered through a private system, a public system, or one in which public and private compete

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23
Q

How long does the approval process for drugs and equipment take in Japan, France, the US and the UK?

A

Japan- 4 years
France - 30 months
US & UK - 18 months

24
Q

What is an “NME”?

A

A New Molecular Entity, which are typically new an innovative drugs approved by the FDA

25
Q

What are the 4 most significant political drivers for the Healthcare sector? And why?

A

1- Government Expenditures (largest payers of health care globally)
2- Legislation (creates uncertainty regarding how laws will be interpreted and implemented)
3- Regulation (FDA responsible for approving/rejecting new products and applications)
4- Taxes (increased industry taxes and fees can stifle innovation/sales. i.e. 2010 Affordable Care Act taxes/fees on med devices)

26
Q

What do firms in the Pharmaceutical and Biotech Industry do?

A

Discover, develop, manufacture and sell prescription drugs to treat humans and animals.

27
Q

What are the differences between the Biotech and Pharma industries?

A

Pharma drugs are composed of chemicals and are called “small molecules”, which are absorbed through the body and can pass through cell membranes
Biotech drugs are composed of living organisms like proteins and are called “large molecules”. They often cannot pass through cell membranes and are commonly injected into the bloodstream

28
Q

What do firms in the “Life Sciences” Industry do?

A

support the bio-pharma industry by providing analytical tools, equipment and supplies. they can also provide clinical trial and other research activities

29
Q

What is a “pure play” company?

A

A firm that concentrates only on one business

30
Q

What percentage of branded drugs end up being profitable?

A

~20%

31
Q

As of June 2014, what are the 3 top selling brand drugs in the US?

A

1) Synthroid - hypothyroid (AbbVie)
2) Crestor - cholesterol (AstraZeneca)
3) Nexium - heartburn (AstraZeneca)

32
Q

How many profitable years does a Pharma company typically have when selling a new drug patent?

A

Patents in the developed world typically last 20 years but, on average, it takes about 10 years to bring a dug to market

33
Q

What % of revenue can a pharma company lose upon brand patent expiration?

A

up to 80% of revenue

34
Q

What are the 3 major types of drug patents?

A

1) Process (the way it’s made)
2) Use (ailment the drug is used to treat)
3) Delivery method

35
Q

What % of a bio-pharma firms revenues are typically spent on R&D?

A

10-40%; on average about 15-20%

36
Q

What is the European equivalent of the FDA?

A

The EMA (European Medicines Agency)

37
Q

What occurs in the 4 phases of testing for an Investigational New Drug (IND)?

A

-preclinical trials on test tubes/ animals must be conducted prior to submitting IND
Phase 1 - Small group of about 30 volunteers used to determine drugs safety/ dosing/ efficacy
Phase 2- up to a few hundred continue test
Phase 3 - (longest and most expensive phase) up to several thousand continue test and use placebos for double blind testing
Phase 4 - continued research to test for safety problems

38
Q

What are “Orphan Drugs”?

A

Drugs that target rare diseases.
-the Orphan Drug Act provides subsidies and exclusive market rights to incentivize companies to develop drugs they wouldn’t otherwise consider

39
Q

What are “approval letters”?

A

FDA requests for additional data and information prior to approval that can significantly delay drug approval

40
Q

What tends to be a Pharma company’s largest expense?

A

Because of marketing, SG&A (on average it’s 25-40% of sales)

41
Q

What is a “formulary list”?

A

A list of approved drugs that a insurance company or government will pay for
-it’s critical for a firm to get its drug on the list and many DTC (direct to consumer) advertisements are an attempt to get patients to demand the drug so it ends up on the list

42
Q

What are OTC drugs?

A

Drugs that don’t require a doctors signature

43
Q

What is a CRO?

A
  • A Contract Research Organization

- does outsourced R&D activities for bio-pharma because they can conduct trials and collect data more efficiently

44
Q

What is the NIH?

A
  • The National Institute of Health (in the United States)

- federal agency conducting and supporting medical research

45
Q

What types of firms operate in the “Health Care Facilities” space?

A
  • hospitals
  • rehabilitation centers
  • nursing homes
46
Q

What types of firms operate in the “Health Care Services” space?

A
  • Laboratory testing

- Pharmacy benefit managers

47
Q

What is a GPO?

A
  • Group Purchasing Organization
  • represent hospitals and physicians to obtain discount pricing through bulk purchases
  • sales are made on a contract basis
  • sales usually consist of conventional (as opposed to high tech) products
48
Q

What is the usual sales exclusivity period for patents on medical devices?

A

-1 or 2 years

49
Q

What does Cardiovascular equipment address? What are typical types of equipment?

A
  • The heart and blood vessels

- Pacemakers/defibrillators to regulate heart rhythm, stents and cardiac valves

50
Q

What is a stent?

A

A tube used to open arteries to allow proper blood flow

51
Q

What does Orthopedic equipment address? What are typical types of equipment?

A
  • The skeletal system (degradation of joints and carteledge)

- artificial knees/joints/hips/etc

52
Q

What does Diagnostic Imaging equipment do? What are typical types of equipment?

A
  • creates images of the body in order to diagnose a certain condition
  • x rays, MRI, ultrasound
53
Q

What does In Vitro Diagnostics equipment do?

A

-tests the blood, tissue and other bodily fluids for disease

54
Q

What does an acute inpatient psychiatric facility do?

A
  • Provide high level of care to stabilize patients that are either a threat to themselves or others
  • provide 24 hour observtion
55
Q

What does a residential treatment center do?

A
  • Treats patients with behavioral disorders in a non-hospital setting
  • balances therapy activities with social, academic and other activities
56
Q

In the payor mix, what is self-pay / third party?

A

Revenues generated primarily through:

1) Acute care hospitals through the unit management division
2) employers through the Employee Assistance Program business