First Stage of Labor Flashcards
Define labor
regular, painful contractions that promote cervical change
Phase 1
quiescence = prelude to parturition.
Contractile unresponsiveness; cervical softening
What inhibits uterine contractions?
1) progesterone
2) prostacyclin
3) relaxin
4) nitric oxide
5) parathyroid hormone-related peptide
6) corticotropin-releasing placental lactogen
Phase 2
activation = preparation for labor
uterine preparedness for labor; cervical ripening
Define uterotropins
1) estrogen
2) prostaglandins
- stimulate upregulation of myometrial receptors for oxytocin and prostaglandins
- activate gap junctions b/w myometrial cells
Phase 3
stimulation = processes of labor
uterine contraction; cervical dilation; fetal and placental expulsion
includes 3 stages of labor
Define uterotonins
promote labor progression
1) prostaglandins
2) oxytocin
Phase 4
involution = parturient recovery
uterine involution; cervical repair; breastfeeding
What promotes involution?
1) oxytocin
2) thrombin
3) prostaglandin
1st clinical stage of labor
begins w/ true labor contractions –> ends with full dilation; comprised of 2 phases
What are the 2 phases of the first stage of clinical labor?
1) latent: contractions become more regular, painful, and frequent BUT little cervical dilation w/ little to no fetal descent
2) active: cervical dilation to completion
Describe receptor changes that stimulate labor
- progesterone binds more readily to PR-A (vs PR-B) –> quiescence ceases
- estrogen stimulates expression of prostaglandin and oxytocin receptors
- myometrial cells develop gap junctions that facilitate direct communication b/w muscle fibers
–> uterine contractions
Goodell’s sign
cervical softening ~4wks after LMP
Chadwick’s sign
increased cervical vascularity ~6wks after LMP (cervix and vaginal walls appear blue)
cervical ripening
rearrangement of collagen prior to and during labor –> become less dense
What are the 4 phases of cervical remodeling?
1) softening
2) ripening
3) dilation
4) postpartum repair
effacement
lengthening of muscle fibers at internal os –> stretches endocervix upward into lower uterine segment
dilation
widening of external os
What promotes dilation?
1) force of contractions
2) hydrostatic action of amniotic fluid
3) pressure of presenting part if ROM
What does passing of mucuos plug indicate?
likely labor w/in 48h
Describe internal rotation
OT/LOA/ROA –> direct OA