First group - inotropic medicines

Question 1

2 main groups

Answer 1

pimobendan

digoxin

Question 2

how to the medicines work with the SNS stimulation

Answer 2

PIMOBENDAN
activtes the enzyme phosphodiesterase which recruits calcium leading to activation of the contractile proteins. also has vasodilation mechanism when activating phosphodiesterase.

DIGOXIN
activates calcium sodium and ATPase pump, increasing intracellular sodium and increasing pumping calcium out of cells. this activates contractile proteins

Question 3

pimobendan

Answer 3

• used in small animals - safer option than digoxin

- known as ‘inodilator’ due to two actions: positive inotropic & vasodilator

Question 4

digoxin

Answer 4

• narrow therapeutic index, positive inotropic

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