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Epilepsy > First Generation ASDs > Flashcards

First Generation ASDs Flashcards

1
Q

MOA OF carbamazepine ?

A

Inhibit voltage Gated sodium channel blocker

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2
Q

True or false
Carbamazepine useful for patient have bipolar disorder and trigeminal neuralgias

A

True

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3
Q

True or false
Carbamazepine make patient have absence seizure better

A

False
Make it worsen
U should avoid it

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4
Q

True or false
Carbamazepine can cause hypernatremia ?

A

False
Hyponatremia

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5
Q

True or false
When take carbamazepine with food that enhance bioavailability?

A

True

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6
Q

MOA OF clonazepam ?

A

Bind GABAa receptor

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7
Q

True or false
Clonazepam usefully with patient have panic disorder and myoclonic seizure

A

True

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8
Q

True or false
Clonazepam if use it with CNS depressant can cause respiratory depression

A

True

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9
Q

True or false
You can use clonazepam with patient have acute narrow angle glaucoma

A

False
Contraindication

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10
Q

Mention SE OF clonazepam

A

Dependant
Hair loss
Hirsutism
Facial edema ( ankle/facial swelling )

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11
Q

MOA of ethosuximide

A

Inhibition of T-type calcium channels

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12
Q

True or false
Use ethosuximide as first line of therapy of children have been diagnosed of absence seizure

A

True

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13
Q

True or false
Ethosuximide is contraindicated of patient have allergy of succinimides

A

True

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14
Q

True or false
Ethosuximide No dose adjustment for patient have hepatic and renal dysfunction

A

False
Use with caution
Dose adjustment

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15
Q

Mention SE of ethosuximide

A

GI distress
Behavioral changes
This the major SE

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16
Q

True or false
Phenobarbital is FDA approved

A

False

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17
Q

MOA of phenobarbital

A

Bind GABAa receptor

18
Q

Indication of phenobarbital

A

Focal onset and generalized seizures

19
Q

True or false
Phenobarbital needed to discontinue suddenly after prolonged use

A

False
Should slow tapering dose

20
Q

What’s the boxed warning of carbamazepine ?

A

Increase risk of SJS/TEN + Aplastic anemia and agranulocytosis

21
Q

True or false
Clonazepam ineffective if patient take with benzodiazepines.

A

False
Effectiveness

22
Q

Mention contraindications of clonazepam ?

A

Acute narrow angle glaucoma
Severe liver impairment

23
Q

Which medication can increase risk of status epilepticus if stopped abruptly?

A

Clonazepam

24
Q

What’s first line medication for children have absent seizures?

A

Ethosuximide
Valproate

25
Q

Medication is contraindication with diabetes patients ?

A

Phenytoin

26
Q

Mention medication can worsen absence seizure ?

A

Carbamazepine - phenytoin

27
Q

Mention SE WITH long term of carbamazepine

A

Hyponatremia - metabolic bone disease

28
Q

Which medication can drop WBC ?

A

Carbamazepine

29
Q

Mention medications have risk of respiratory depression when take it with CNS depressants

A

Phenobarbital - clonazepam

30
Q

MOA OF phenytoin

A

Inhibit voltage gated sodium channels

31
Q

True or false
Phenobarbital can reduce effectiveness of OCC.

A

True

32
Q

Which medication interact with warfarin ?

A

Phenytoin

33
Q

Mention medication can cause gingival hyperplasia

A

Phenytoin

34
Q

True or false
Valproate is patient have bipolar disorder and migraine

A

True

35
Q

Medication can cause purple glove syndrome

A

Fosphenytoin

36
Q

Is carbamazepine can cause diplopsia and blurred vision and ataxia

A

True

37
Q

Medication cause neural tube defects

A

Valproate

38
Q

True or false
Valproate is broad spectrum Anti seizure

A

True

39
Q

Which medication cause cleft malformation

A

Topiramate

40
Q

True or false
Valproate can cause weight loss

A

False
Weight gain

41
Q

Definition :
Patient will have seizures only associated with fever

A

Caller
Febrile seizure
Not epilepsy

Epilepsy (3 decks)

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