First Generation ASDs Flashcards
MOA OF carbamazepine ?
Inhibit voltage Gated sodium channel blocker
True or false
Carbamazepine useful for patient have bipolar disorder and trigeminal neuralgias
True
True or false
Carbamazepine make patient have absence seizure better
False
Make it worsen
U should avoid it
True or false
Carbamazepine can cause hypernatremia ?
False
Hyponatremia
True or false
When take carbamazepine with food that enhance bioavailability?
True
MOA OF clonazepam ?
Bind GABAa receptor
True or false
Clonazepam usefully with patient have panic disorder and myoclonic seizure
True
True or false
Clonazepam if use it with CNS depressant can cause respiratory depression
True
True or false
You can use clonazepam with patient have acute narrow angle glaucoma
False
Contraindication
Mention SE OF clonazepam
Dependant
Hair loss
Hirsutism
Facial edema ( ankle/facial swelling )
MOA of ethosuximide
Inhibition of T-type calcium channels
True or false
Use ethosuximide as first line of therapy of children have been diagnosed of absence seizure
True
True or false
Ethosuximide is contraindicated of patient have allergy of succinimides
True
True or false
Ethosuximide No dose adjustment for patient have hepatic and renal dysfunction
False
Use with caution
Dose adjustment
Mention SE of ethosuximide
GI distress
Behavioral changes
This the major SE
True or false
Phenobarbital is FDA approved
False
MOA of phenobarbital
Bind GABAa receptor
Indication of phenobarbital
Focal onset and generalized seizures
True or false
Phenobarbital needed to discontinue suddenly after prolonged use
False
Should slow tapering dose
What’s the boxed warning of carbamazepine ?
Increase risk of SJS/TEN + Aplastic anemia and agranulocytosis
True or false
Clonazepam ineffective if patient take with benzodiazepines.
False
Effectiveness
Mention contraindications of clonazepam ?
Acute narrow angle glaucoma
Severe liver impairment
Which medication can increase risk of status epilepticus if stopped abruptly?
Clonazepam
What’s first line medication for children have absent seizures?
Ethosuximide
Valproate
Medication is contraindication with diabetes patients ?
Phenytoin
Mention medication can worsen absence seizure ?
Carbamazepine - phenytoin
Mention SE WITH long term of carbamazepine
Hyponatremia - metabolic bone disease
Which medication can drop WBC ?
Carbamazepine
Mention medications have risk of respiratory depression when take it with CNS depressants
Phenobarbital - clonazepam
MOA OF phenytoin
Inhibit voltage gated sodium channels
True or false
Phenobarbital can reduce effectiveness of OCC.
True
Which medication interact with warfarin ?
Phenytoin
Mention medication can cause gingival hyperplasia
Phenytoin
True or false
Valproate is patient have bipolar disorder and migraine
True
Medication can cause purple glove syndrome
Fosphenytoin
Is carbamazepine can cause diplopsia and blurred vision and ataxia
True
Medication cause neural tube defects
Valproate
True or false
Valproate is broad spectrum Anti seizure
True
Which medication cause cleft malformation
Topiramate
True or false
Valproate can cause weight loss
False
Weight gain
Definition :
Patient will have seizures only associated with fever
Caller
Febrile seizure
Not epilepsy
