First Generation ASDs

Question 1

MOA OF carbamazepine ?

Answer 1

Inhibit voltage Gated sodium channel blocker

Question 2

True or false
Carbamazepine useful for patient have bipolar disorder and trigeminal neuralgias

Answer 2

True

Question 3

True or false
Carbamazepine make patient have absence seizure better

Answer 3

False
Make it worsen
U should avoid it

Question 4

True or false
Carbamazepine can cause hypernatremia ?

Answer 4

False
Hyponatremia

Question 5

True or false
When take carbamazepine with food that enhance bioavailability?

Answer 5

True

Question 6

MOA OF clonazepam ?

Answer 6

Bind GABAa receptor

Question 7

True or false
Clonazepam usefully with patient have panic disorder and myoclonic seizure

Answer 7

True

Question 8

True or false
Clonazepam if use it with CNS depressant can cause respiratory depression

Answer 8

True

Question 9

True or false
You can use clonazepam with patient have acute narrow angle glaucoma

Answer 9

False
Contraindication

Question 10

Mention SE OF clonazepam

Answer 10

Dependant
Hair loss
Hirsutism
Facial edema ( ankle/facial swelling )

Question 11

MOA of ethosuximide

Answer 11

Inhibition of T-type calcium channels

Question 12

True or false
Use ethosuximide as first line of therapy of children have been diagnosed of absence seizure

Answer 12

True

Question 13

True or false
Ethosuximide is contraindicated of patient have allergy of succinimides

Answer 13

True

Question 14

True or false
Ethosuximide No dose adjustment for patient have hepatic and renal dysfunction

Answer 14

False
Use with caution
Dose adjustment

Question 15

Mention SE of ethosuximide

Answer 15

GI distress
Behavioral changes
This the major SE

Question 16

True or false
Phenobarbital is FDA approved

Answer 16

False

Question 17

MOA of phenobarbital

Answer 17

Bind GABAa receptor

Question 18

Indication of phenobarbital

Answer 18

Focal onset and generalized seizures

Question 19

True or false
Phenobarbital needed to discontinue suddenly after prolonged use

Answer 19

False
Should slow tapering dose

Question 20

What’s the boxed warning of carbamazepine ?

Answer 20

Increase risk of SJS/TEN + Aplastic anemia and agranulocytosis

Question 21

True or false
Clonazepam ineffective if patient take with benzodiazepines.

Answer 21

False
Effectiveness

Question 22

Mention contraindications of clonazepam ?

Answer 22

Acute narrow angle glaucoma
Severe liver impairment

Question 23

Which medication can increase risk of status epilepticus if stopped abruptly?

Answer 23

Clonazepam

Question 24

What’s first line medication for children have absent seizures?

Answer 24

Ethosuximide
Valproate

Question 25

Medication is contraindication with diabetes patients ?

Answer 25

Phenytoin

Question 26

Mention medication can worsen absence seizure ?

Answer 26

Carbamazepine - phenytoin

Question 27

Mention SE WITH long term of carbamazepine

Answer 27

Hyponatremia - metabolic bone disease

Question 28

Which medication can drop WBC ?

Answer 28

Carbamazepine

Question 29

Mention medications have risk of respiratory depression when take it with CNS depressants

Answer 29

Phenobarbital - clonazepam

Question 30

MOA OF phenytoin

Answer 30

Inhibit voltage gated sodium channels

Question 31

True or false Phenobarbital can reduce effectiveness of OCC.

Answer 31

True

Question 32

Which medication interact with warfarin ?

Answer 32

Phenytoin

Question 33

Mention medication can cause gingival hyperplasia

Answer 33

Phenytoin

Question 34

True or false Valproate is patient have bipolar disorder and migraine

Answer 34

True

Question 35

Medication can cause purple glove syndrome

Answer 35

Fosphenytoin

Question 36

Is carbamazepine can cause diplopsia and blurred vision and ataxia

Answer 36

True

Question 37

Medication cause neural tube defects

Answer 37

Valproate

Question 38

True or false Valproate is broad spectrum Anti seizure

Answer 38

True

Question 39

Which medication cause cleft malformation

Answer 39

Topiramate

Question 40

True or false Valproate can cause weight loss

Answer 40

False Weight gain

Question 41

Definition : Patient will have seizures only associated with fever

Answer 41

Caller Febrile seizure Not epilepsy