Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Veterinary Cannabis Counselor Course > First attempt- do not use > Flashcards

First attempt- do not use Flashcards

Module 1 - Introduction to the Endocannabinoid System

1
Q

what is the role of the veterinary team?

A

Prevention of harm
patient advocacy
maintain and strengthen the VCPR
Scientific and medical advancement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ECS: a system of balance

A

inter and intra-cellular communication
regulation between cell system
maintain whole-body homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ECS consists of:

A

Cannabinoid receptors
Cannabinoids
Enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cannabinoid receptor Characteristics

A

G-protein coupled receptors

  • membrane-bound
  • Conformation change with ligand binding
  • activation results in intracellular signaling
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CB1 receptors are located?

A

Primarily within the nervous system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CB2 receptors are located?

A

Primarily within peripheral tissue , immune system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

CB1 receptor target, name a few?

A 
motor activity
thinking
appetite
pain perception
immune cells
motor coordination
short term memory
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CB2 receptors influence most of the body, name a few?

A

Gut, kidneys, pancreas, adipose tissue, skeletal muscle, bone, eye, tumors, repo system, immune system, respiratory tract, skin, CNS, cardiovascular system, liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CB1 receptor is located where on the neuron?

A

Pre-synaptic neuron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Glutamate =

A

Excitatory signal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

GABA =

A

Inhibitory signal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Retrograde feedback results in diverse effects

A

Depolarization-induced suppression of excitation (DSE)
inhibition of Glutamate
Depolarization-induced suppression of inhibition (DSI)
Inhibition of GABA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CB1 receptors =

A

Neuro-modulatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Endocannabinoids (eCBs)

A

Anandamide (AEA)

2-arachidonoylglycerol (2-AG)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

eCBS are lipid-derived, enzyme activated and “On Demand”, inactive precursors are?

A

NAPE-PLD > AEA

DAGLa > 2-AG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

AEA is degraded by?

A

FAAH- Fatty acid amide hydrolase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

2-AG is degraded by?

A

MGL- Monoglyceral lipase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Exogenous Cannabinoids are?

A

THC- delta-9-tetrahydrocannabinol
-direct agonist

CBD- Cannabidinol
-eCB reuptake inhibiton

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

There’s so MUCH MORE than CBD and THC

A

Cannabis plants produce over 180 cannabinoids, terpenes, and flavinoids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

CB2 receptor density can increase up to 100x in response?

A

to inflammation, Allows for targeting of injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

CB2 receptors =

A

immuno-modulatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Temporal control

A 
retrograde feedback (CB1)
on-demand production/rapid degradation (eCBs)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Spatial Control

A

pre-synaptic location (CB1)

increase CB2 receptors in injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Phyto-cannabinoids and synthetic cannabinoids are examples of?

A

exogenous cannabinoids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

There’s so MUCH MORE than CBD and THC

A

Cannabis plants produce over 180 cannabinoids:
CBD, THC, CBG, CBN, CBDa….
terpenes: essential oils/aromatherapy
Flavinoids

26
Q

The sum is greater than the parts

A

Entourage effect (Synergy)

27
Q

Complex molecular profile provides

A

increased safety
increased therapeutic potential
unique synergistic effects

28
Q

Cannabidiol (CBD)

Supportive and regulatory effects

A 
Indirect agonist
eCB reuptake inhibition
-Inhibition of FAAH
Allosteric binding at CB1
Activity outside of the ECS
29
Q

Affects metabolism of >60% of pharmaceuticals, such as?

A

Steroids/NSAIDs

antidepressants

30
Q

delta-9-tetrahydrocannabinol (THC)

Strong anti-inflammatory and pain control effects

A

Activity at agonist-activated cannabinoid receptor (CB1)
Modulate nociceptive thresholds
inhibit release of pro-inflammatory molecules
Synergy with endogenous opioid system

31
Q

THC side effects are?

A

Sensitivity to light
Sensitivity to sound
ANXIETY in animals

32
Q

Clinical applications for THC

A

Severe inflammation
Uncontrolled/neurogenic pain
Cancer treatments

33
Q

Clinical applications for CBD

A

Chronic disease
immune deficiencies/stress
behavior disorders

34
Q

Clinical applications for CBD isolate

A

situational anxiety

35
Q

Clinical applications for CBD + minor cannabinoids + terpenes

A

complex anxiety
chronic anxiety
concurrent diseases

36
Q

Clinical applications for CDB + THC + minor cannabinoids + terpenes

A 
severe anxiety and complex conditions
concurrent diseases (pain, inflammation)
37
Q

Ask for a

Certificate of Analysis

A

Practionersmust know the molecular profiles of a cannabis product
essential for patient safety
essential for consumer protection

38
Q

Cannabis species?

A

Cannabis sativa
Cannabis indica
Cannabis ruderalis

39
Q

industrial hemp vs marijuana

A

<0.3% THC = industrial hemp

>0.3% THC = marijuana

40
Q

Neuronal plasticity

A

adapts to the signal being passed, neuro-modulatory

41
Q

Anandamide

A

direct agonist

42
Q

2-arachidonoylglycerol (2-AG)

A

partial agonist

43
Q

ECS is responsible for?

A

balance, regulation, and homeostasis

44
Q

ECS present in all vertebrates, best understood in mammals

A

responsible for whole-body homeostasis

45
Q

The Endocannabinoid system first discovered in?

A

1980’s

46
Q

Humans have Clinical endocannabinoid deficiency syndrome, linked to?

A

migraines, IBS, fibromyalgia

47
Q

Biochemical assay via laboratory analysis, COA

A

Quantifies cannabinoid and non-cannabinoid molecules.

ex: terpenes

48
Q

The terpene myrcene effect is?

A

contributes a strong sedating effect, hypnotic, analgesic, and muscle relaxant. myrcene acts as an anti-inflammatory interfering in the prostaglandins metabolic pathway

49
Q

The terpene limonene effect is?

A

provides an uplifting effect. anxiolytic effects, causing a rise in serotonin and dopamine

50
Q

The terpene linolol effect is?

A

an anxiolytic effect. anti-seizure properties that inhibit glutamatergic activity

51
Q

The terpene pinene effect is?

A

anti-inflammatory properties, significant antibiotic effects even against antibiotic-resistant pathogens. acts as a bronchodilator in humans at low inhaled concentrations

52
Q

The terpene Beta-caryophyelle effect is?

A

antifungal effects, anti-inflammatory properties one by blocking prostaglandins inflammatory pathway and as a CB2 agonsit

53
Q

Cannabis plants are exceptionally capable of extracting substances from the environment, such as soil, and accumulating these substances within the structure of the plant itself.

A

Phytoremediation “Plant remedy” a process by which a plant is able to remove degrade, or contain contamination

54
Q

The cannabis plants contain many phytocannabinoids with weak or null psychoactivity.

A

CBD- anti-oxidant and anti-inflammatory
CBDA- an inhibitor of selective COX-2 with anti-inflammatory effects
CBG- acts against proliferation and as an antibacterial
CBC- can cause hypothermia, sedation, and hypoactivity in mice. also acts as an anti-inflammatory, and anti-microbial, and a soft analgesic

55
Q

The terpene eucalyptol effect is?

A

Clinical efficacy for treating asthma and sinusitis, anti-inflammatory and a local anesthetic. has also been shown to have immunosuppressive and in vitro anti-leukemia properties

56
Q

Flavonoids have relevant pharmacological activities, like?

A

antioxidants, anti-inflammatory, antiallergic, antibiotic, antidiarrheal and against cancer

57
Q

The flavonoids Cannflavins A, B, and C effects are?

A

Anti-inflammatory

58
Q

The flavonoids Vitexin and isovitexin effects are?

A

inhibiting the thyroid peroxidase, therapeutic applicability for gout

59
Q

The flavonoid kaempferol effects are?

A

antidepressant, mat reduce risk of cancer and some coronary disease with kaempferol rich diets

60
Q

The flavonoid Apigenin effects are?

A

acts as an anxiolytic and sedative on the GABA receptor. capable of stimulating the monoamine transporter, altering neurotransmitter levels. also shown to decrease the secondary effects of ciclosporin A.

61
Q

The flavonoid Quercitin effects are?

A

inhibits viral enzymes and can have antiviral effects. inhibits production prostaglandins, acting as an anti-inflammatory. inhibits MAO!

62
Q

The flavonoids luteonin and orientin effects are?

A

Shown to have antioxidant, anti-inflammatory, antibiotic and act as an agent against cancer.

Veterinary Cannabis Counselor Course (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions