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First Aid- Classic presentations > First Aid Key Associations > Flashcards

First Aid Key Associations Flashcards

1
Q

Mitochondrial inheritance

A

Disease occurs in both males and females, inherited

through females only

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2
Q

Intellectual disability

A

Down syndrome, fragile X syndrome

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3
Q

Vitamin deficiency (USA)

A

Folate (pregnant women are at high risk; body stores only

3- to 4-month supply; prevents neural tube defects)

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4
Q

Lysosomal storage disease

A

Gaucher disease

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5
Q

Bacterial meningitis (adults and elderly)

A

Streptococcus pneumoniae

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6
Q

Bacterial meningitis (newborns and kids)

A

Group B streptococcus/E coli/Listeria monocytogenes

newborns), S pneumoniae/N meningitidis (kids/teens

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7
Q

HLA-DR3

A

Diabetes mellitus type 1, SLE, Graves disease, Hashimoto
thyroiditis (also associated with HLA-DR5), Addison
disease

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8
Q

HLA-DR4

A

Diabetes mellitus type 1, rheumatoid arthritis, Addison

disease

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9
Q 
Bacteria associated with gastritis, peptic ulcer disease, and
gastric malignancies (eg, adenocarcinoma, MALToma)
A

H pylori

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10
Q

Opportunistic infection in AIDS

A

Pneumocystis jirovecii pneumonia

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11
Q

Helminth infection (US)

A

Enterobius vermicularis

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12
Q

Viral encephalitis affecting temporal lobe

A

HSV-1

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13
Q

Infection 2° to blood transfusion

A

Hepatitis C

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14
Q

Food poisoning (exotoxin mediated)

A

S aureus, B cereus

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15
Q

Osteomyelitis

A

S aureus (most common overall)

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16
Q

Osteomyelitis in sickle cell disease

A

Salmonella

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17
Q

Osteomyelitis with IV drug use

A

Pseudomonas, Candida, S aureus

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18
Q

UTI

A

E coli, Staphylococcus saprophyticus (young women)

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19
Q

Sexually transmitted disease

A

C trachomatis (usually coinfected with N gonorrhoeae)

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20
Q

Nosocomial pneumonia

A

S aureus, Pseudomonas, other enteric gram ⊝ rods

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21
Q

Pelvic inflammatory disease

A

C trachomatis, N gonorrhoeae

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22
Q

Infections in chronic granulomatous disease

A

S aureus, E coli, Aspergillus (catalase ⊕)

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23
Q

Metastases to bone

A

Prostate, breast > kidney, thyroid, lung

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24
Q

Metastases to brain

A

Lung > breast > melanoma, colon, kidney

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25
Q

Metastases to liver

A

Colon&raquo_space; stomach > pancreas

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26
Q

S3 heart sound

A

ventricular filling pressure (eg, mitral regurgitation,

HF), common in dilated ventricles

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27
Q

S4 heart sound

A

Stiff/hypertrophic ventricle (aortic stenosis, restrictive

cardiomyopathy)

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28
Q

Constrictive pericarditis

A

TB (developing world); idiopathic, viral illness (developed

world)

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29
Q

Holosystolic murmur

A

VSD, tricuspid regurgitation, mitral regurgitation

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30
Q

Ejection click

A

Aortic stenosis

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31
Q

Mitral valve stenosis

A

Rheumatic heart disease

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32
Q

Opening snap

A

Mitral Stenosis

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33
Q

Heart murmur, congenital

A

Mitral valve prolapse

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34
Q

Chronic arrhythmia

A

Atrial fibrillation (associated with high risk of emboli)

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35
Q

Cyanosis (early; less common)

A

Tetralogy of Fallot, transposition of great vessels, truncus
arteriosus, total anomalous pulmonary venous return,
tricuspid atresia

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36
Q

Late cyanotic shunt (uncorrected left to right becomes

right to left)

A 
Eisenmenger syndrome (caused by ASD, VSD, PDA;
results in pulmonary hypertension/polycythemia)
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37
Q

Congenital cardiac anomaly

A

VSD

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38
Q

Hypertension, 2°

A

Renal artery stenosis, chronic kidney disease (eg,
polycystic kidney disease, diabetic nephropathy),
hyperaldosteronism

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39
Q

Aortic aneurysm, thoracic

A

Marfan syndrome (idiopathic cystic medial degeneration)

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40
Q

Aortic aneurysm, abdominal

A

Atherosclerosis, smoking is major risk factor

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41
Q

Aortic aneurysm, ascending or arch

A

3° syphilis (syphilitic aortitis), vasa vasorum destruction

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42
Q

Sites of atherosclerosis

A

Abdominal aorta > coronary artery > popliteal artery

> carotid artery

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43
Q

Aortic dissection

A

Hypertension

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44
Q

Right heart failure due to a pulmonary cause

A

Cor pulmonale

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45
Q

Heart valve in bacterial endocarditis

A

Mitral > aortic (rheumatic fever), tricuspid (IV drug abuse)

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46
Q

Endocarditis presentation associated with bacterium

A

S aureus (acute, IVDA, tricuspid valve), viridans
streptococci (subacute, dental procedure), S bovis (colon
cancer), culture negative (Coxiella, Bartonella, HACEK)

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47
Q

Temporal arteritis

A

Risk of ipsilateral blindness due to occlusion of

ophthalmic artery; polymyalgia rheumatica

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48
Q

Recurrent inflammation/thrombosis of small/medium

vessels in extremities

A

Buerger disease (strongly associated with tobacco)

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49
Q

Cardiac 1° tumor (kids)

A

Rhabdomyoma, often seen in tuberous sclerosis

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50
Q

Cardiac tumor (adults)

A

Metastasis, myxoma (90% in left atrium; “ball valve”)

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51
Q

Congenital adrenal hyperplasia, hypotension

A

21-hydroxylase deficiency

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52
Q

Hypopituitarism

A

Pituitary adenoma (usually benign tumor)

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53
Q

Cretinism

A

Iodine deficit/congenital hypothyroidism

54
Q

Thyroid cancer

A

Papillary carcinoma (childhood irradiation)

55
Q

Hypoparathyroidism

A

Accidental excision during thyroidectomy

56
Q

1° hyperparathyroidism

A

Adenomas, hyperplasia, carcinoma

57
Q

2° hyperparathyroidism

A

Hypocalcemia of chronic kidney disease

58
Q

Cushing syndrome

A

Iatrogenic (from corticosteroid therapy)
Adrenocortical adenoma (secretes excess cortisol)
ACTH-secreting pituitary adenoma (Cushing disease)
Paraneoplastic (due to ACTH secretion by tumors)

59
Q

1° hyperaldosteronism

A

Adrenal hyperplasia or adenoma

60
Q

Tumor of the adrenal medulla (kids)

A

Neuroblastoma (malignant)

61
Q

Tumor of the adrenal medulla (adults)

A

Pheochromocytoma (usually benign)

62
Q

Refractory peptic ulcers and high gastrin levels

A

Zollinger-Ellison syndrome (gastrinoma of duodenum or

pancreas), associated with MEN1

63
Q

Esophageal cancer

A

Squamous cell carcinoma (worldwide); adenocarcinoma

US

64
Q

Acute gastric ulcer associated with CNS injury

A

Cushing ulcer ( intracranial pressure stimulates vagal

gastric H+ secretion)

65
Q

Acute gastric ulcer associated with severe burns

A

Curling ulcer (greatly reduced plasma volume results in

sloughing of gastric mucosa)

66
Q

Bilateral ovarian metastases from gastric carcinoma

A

Krukenberg tumor (mucin-secreting signet ring cells)

67
Q

Chronic atrophic gastritis (autoimmune)

A

Predisposition to gastric carcinoma (can also cause

pernicious anemia)

68
Q

Gastric cancer

A

Adenocarcinoma

69
Q

Alternating areas of transmural inflammation and normal

colon

A

Skip lesions (Crohn disease)

70
Q

Site of diverticula

A

Sigmoid colon

71
Q

Diverticulum in pharynx

A

Zenker diverticulum (diagnosed by barium swallow)

72
Q

Hepatocellular carcinoma

A

Cirrhotic liver (associated with hepatitis B and C,

alcoholism, and hemochromatosis)

73
Q

Liver disease

A

Alcoholic cirrhosis

74
Q

1° liver cancer

A

Hepatocellular carcinoma (chronic hepatitis, cirrhosis,

hemochromatosis, α1

-antitrypsin deficiency, Wilson

disease)

75
Q

Congenital conjugated hyperbilirubinemia (black liver)

A

Dubin-Johnson syndrome (inability of hepatocytes to

secrete conjugated bilirubin into bile)

76
Q

Hereditary harmless jaundice

A

Gilbert syndrome (benign congenital unconjugated

hyperbilirubinemia)

77
Q

Hemochromatosis

A

Multiple blood transfusions or hereditary HFE mutation
(can result in heart failure, “bronze diabetes,” and risk
of hepatocellular carcinoma)

78
Q

Pancreatitis (acute)

A

Gallstones, alcohol

79
Q

Pancreatitis (chronic)

A

Alcohol (adults), cystic fibrosis (kids)

80
Q

Microcytic anemia

A

Iron deficiency

81
Q

Autosplenectomy (fibrosis and shrinkage)

A

Sickle cell disease (hemoglobin S)

82
Q

Bleeding disorder with GpIb deficiency

A

Bernard-Soulier syndrome (defect in platelet adhesion to

von Willebrand factor)

83
Q

Hereditary bleeding disorder

A

von Willebrand disease

84
Q

DIC

A

Severe sepsis, obstetric complications, cancer, burns,

trauma, major surgery, acute pancreatitis, APL

85
Q

Malignancy associated with noninfectious fever

A

Hodgkin lymphoma

86
Q

Type of Hodgkin lymphoma

A 
Nodular sclerosis (vs mixed cellularity, lymphocytic
predominance, lymphocytic depletion)
87
Q

t(14;18)

A

Follicular lymphomas (BCL-2 activation, anti-apoptotic

oncogene)

88
Q

t(8;14)

A

Burkitt lymphoma (c-myc fusion, transcription factor

oncogene)

89
Q

Type of non-Hodgkin lymphoma

A

Diffuse large B-cell lymphoma

90
Q

1° bone tumor (adults)

A

Multiple myeloma

91
Q

Age ranges for patient with ALL/CLL/AML/CML

A

ALL: child, CLL: adult > 60, AML: adult ∼ 65, CML:

adult 45–85

92
Q

Malignancy (kids)

A

Leukemia, brain tumors

93
Q

Death in CML

A

Blast crisis

94
Q

t(9;22)

A

Philadelphia chromosome, CML (BCR-ABL oncogene,
tyrosine kinase activation), more rarely associated with
ALL

95
Q

Vertebral compression fracture

A

Osteoporosis (type I: postmenopausal woman; type II:

elderly man or woman)

96
Q

HLA-B27

A

Psoriatic arthritis, ankylosing spondylitis, IBD-associated

arthritis, reactive arthritis (formerly Reiter syndrome)

97
Q

Death in SLE

A

Lupus nephropathy

98
Q

Tumor of infancy

A

Strawberry hemangioma (grows rapidly and regresses

spontaneously by childhood)

99
Q

Actinic (solar) keratosis

A

Precursor to squamous cell carcinoma

100
Q

Cerebellar tonsillar herniation

A

Chiari I malformation

101
Q

Atrophy of the mammillary bodies

A

Wernicke encephalopathy (thiamine deficiency causing

ataxia, ophthalmoplegia, and confusion)

102
Q

Epidural hematoma

A

Rupture of middle meningeal artery (trauma; lentiform

shaped)

103
Q

Subdural hematoma

A

Rupture of bridging veins (crescent shaped)

104
Q

Dementia

A

Alzheimer disease, multiple infarcts (vascular dementia)

105
Q

Demyelinating disease in young women

A

Multiple sclerosis

106
Q

Brain tumor (adults)

A

Supratentorial: metastasis, astrocytoma (including

glioblastoma multiforme), meningioma, schwannoma

107
Q

Pituitary tumor

A

Prolactinoma, somatotropic adenoma

108
Q

Brain tumor (kids)

A

Infratentorial: medulloblastoma (cerebellum) or

supratentorial: craniopharyngioma

109
Q

Mixed (UMN and LMN) motor neuron disease

A

Amyotrophic lateral sclerosis

110
Q

Degeneration of dorsal column fibers

A 
Tabes dorsalis (3° syphilis), subacute combined
degeneration (dorsal columns, lateral corticospinal,
spinocerebellar tracts affected)
111
Q

Nephrotic syndrome (adults)

A

Membranous nephropathy

112
Q

Nephrotic syndrome (kids)

A

Minimal change disease

113
Q

Glomerulonephritis (adults)

A

Berger disease (IgA nephropathy)

114
Q

Kidney stones

A

Calcium = radiopaque

Struvite (ammonium) = radiopaque (formed by urease
⊕ organisms such as Klebsiella, Proteus species, and
S saprophyticus)
Uric acid = radiolucent
Cystine = faintly radiopaque

115
Q

Renal tumor

A

Renal cell carcinoma: associated with von Hippel-Lindau
and cigarette smoking; paraneoplastic syndromes (EPO,
renin, PTHrP, ACTH)

116
Q

Obstruction of male urinary tract

A

BPH

117
Q

1° amenorrhea

A

Turner syndrome (45,XO or 45,XO/46,XX mosaic)

118
Q

Neuron migration failure

A

Kallmann syndrome (hypogonadotropic hypogonadism

and anosmia)

119
Q

Clear cell adenocarcinoma of the vagina

A

DES exposure in utero

120
Q

Ovarian tumor (benign, bilateral)

A

Serous cystadenoma

121
Q

Ovarian tumor (malignant)

A

Serous cystadenocarcinoma

122
Q

Tumor in women

A

Leiomyoma (estrogen dependent, not precancerous)

123
Q

Gynecologic malignancy

A

Endometrial carcinoma (most common in US); cervical

carcinoma (most common worldwide)

124
Q

Breast mass

A

Fibrocystic change, carcinoma (in postmenopausal

women)

125
Q

Breast tumor (benign, young woman)

A

Fibroadenoma

126
Q

Breast cancer

A

Invasive ductal carcinoma

127
Q

Testicular tumor

A

Seminoma (malignant, radiosensitive), placental ALP

128
Q

Pulmonary hypertension

A

Idiopathic, heritable, left heart disease (eg, HF), lung
disease (eg, COPD), hypoxemic vasoconstriction (eg,
OSA), thromboembolic (eg, PE)

129
Q

Hypercoagulability, endothelial damage, blood stasis

A

Virchow triad ( risk of thrombosis)

130
Q

SIADH

A

Small cell carcinoma of the lung

First Aid- Classic presentations (2 decks)

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