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First Aid Allergy and Immunology > First Aid, Chapter 4 Laboratory Tests, Cell Surface Markers and Receptors > Flashcards

First Aid, Chapter 4 Laboratory Tests, Cell Surface Markers and Receptors Flashcards

1
Q

What are the roles of cell surface molecules?

A

Cell surface makers play a role in the following:

  • Recognition
  • Adhesion
  • Signal transduction
  • Cell recognition in research
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2
Q

What do cluster of differentiation markers do? What are their roles?

A

Cluster of differentiation (CD) markers signal the presence of cell surface proteins, which leads to the identification and characterization of leukocytes.
CD markers have multiple roles:
-Cell identification
-Antigen or cytokine receptors

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3
Q

What are other names for CD? Where are they expressed? What is the structure? What is its function?

A

Other names:
Expression:
Structure:
Function:

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4
Q

What are other names for CD1? Where are they expressed? What is the structure? What is its function?

A

Other names:
Five subsets CD1a– e CD1a (Leu6)
Expression: APCs
Structure: Member of Ig superfamily, binds to β2microglobuli
Function: Presents autologous and bacterial lipid antigen to T lymphocytes

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5
Q

What are other names for CD2? Where are they expressed? What is the structure? What is its function?

A 
Other names: LFA2, E rosette receptor
Expression: Early T and NK cells
Structure: Ig superfamily 
Function: 
Binds LFA3 (CD58) on APC Activates T lymphocytes Induces cytokine production Mediates adhesion between T lymphocytes and APCs Inhibits apoptosis of activated T lymphocytes
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6
Q

Where are CD3 expressed? What is the structure? What is its function?

A

Expression: T lymphocytes (plasma cells, macrophage) Not found on NK cells
Structure: Ig superfamily δ, ε, γ, and ζ chains
Function: Required for TCR expression and signal transduction δ, ε, γ, and ζ defects causes T-B+NK+ SCID OKT3—monoclonal antibody clone, which recognizes human CD3 in the treatment of solid-organ transplant rejection and acute Tlymphocyte ALL. Leads to activation then apoptosis of T-cells causing immunosuppression

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7
Q

What are other names for CD14? Where are they expressed? What is the structure? What is its function?

A

Other names: LPS receptor
Expression: Macrophages and monocytes
Structure: Pattern recognition receptor
Function: Detects lipoteichoic acid on GPB, and LPS on GNB, mycobacteria, and fungi Mediates IL-12 and IFNγ production

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8
Q

What are other names for CD16 (the A receptor)? Where are they expressed? What is its function?

A 
Other names: 
FcγRIIIA Low-affinity IgGR 
Expression:
NK cells, granulocytes, and macrophages 
Function: ADCC
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9
Q

What are other names for CD16 (the B receptor)? Where are they expressed? What is the structure? What is its function?

A

Other names: FcγRIIIB Low-affinity IgGR
Expression: Neutrophils
Structure: Most common IgG FcR
Function: Phagocytosis

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10
Q

What are other names for CD18? Where are they expressed? What is the structure? What is its function?

A

Other names: B2 chain
Expression: Neutrophils, macrophages, monocytes, and NK cells
Structure: Combines with αL: LFA1, (CD11aCD18), αM: MAC-1 and CR3 (CD11bCD18), αX: p150,95 and CR4 (CD11cCD18)
Function:
Adhesion and signaling Defect in common β chain responsible for LAD1

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11
Q

Where are CD19 expressed? What is the structure? What is its function?

A

Expression: Pre B lymphocytes, B lymphocytes, and follicular dendritic cells
Structure: Coreceptor with CD21
Function: B-lymphocyte ontogeny and activation

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12
Q

What are other names for CD20? Where are they expressed? What is the structure? What is its function?

A

Other names: L26 MS4A1
Expression:
On B lymphocytes after CD19 expression Follicular dendritic cells
Structure: Transmembra ne phosphoprotei n—forms structure like ion channel— Ca influx
Function: B lymphocyte activation and signaling

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13
Q

What are other names for CD21? Where are they expressed? What is its function?

A

Other names: CR2 C3d receptor EBV receptor
Expression: Mature B lymphocytes and follicular dendritic cells
Function: Binds EBV, HHV8, C3d, and CD23 High levels of CD21lo B cells are associated with CVID class Ia

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14
Q

What are other names for CD22? Where are they expressed? What is its function?

A

Other names: B-lymphocyte cell adhesion molecule (BLCAM)
Expression: B lymphocytes
Function: Inhibits B signaling

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15
Q

What are other names for CD23? Where are they expressed? What is the structure? What is its function?

A

Other names: Low affinity IgE receptor FCeRII
Expression: activated, mature B lymphocytes and follicular dendritic cells
Structure: Type C lectin
Function: B-lymphocyte ontogeny and activation

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16
Q

Which cell marker of the following is not found on NK cells: CD3, CD16, CD56?

A

CD3

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17
Q

What are other names for CD25? Where are they expressed? What is its function?

A

Other names: IL-2 Ra chain
Expression: Activated B and T lymphocytes
Function: Suppress self-reactive T lymphocytes. prevent CTL cytolysis, and suppress NK cells. Elevated in HLH

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18
Q

What are other names for CD27? Where are they expressed? What is the structure? What is its function?

A

Other names: TNFRSF7
Expression: Memory B lymphocytes
Structure: TNF receptor superfamily
Function: B-lymphocyte activation and Ig production Memory B lymphocytes: CD27+ Memory T lymphocytes: CD27-

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19
Q

What are other names for CD31? Where are they expressed? What is the structure? What is its function?

A

Other names: PECAM-1
Expression: Endothelial cells, platelets, monocytes, and macrophage
Structure: Ig Superfamily
Function: Cell adhesion and bind CD38

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20
Q

What are other names for CD32? Where are they expressed? What is its function?

A

Other names: FcγRII (types a, b, and c)
Expression: WBCs
Function: Binds Fc of IgG immune complexes to remove foreign antigens Binding of FcγRIIb proposed mechanism of IVIG

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21
Q

Where is CD34 expressed? What is its function?

A

Expression: Adult hematopoietic stem cells
Function: Adhesion molecule and binds CD62L (L selectin)

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22
Q

What are other names for CD35? Where are they expressed? What is its function?

A

Other names: CR1 C3b and C4b receptor
Expression: WBCs
Function: Binds immune complexes coated with C3b and C4b Cofactor for factor Imediated cleavage

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23
Q

What are other names for CD40? Where are they expressed? What is its function?

A

Other names: TNFRSF5
Expression: APCs
Function: T–lymphocyte-dependent Ig switching Expressed on B cells Defective in HIGM3

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24
Q

Where is CD44 expressed? What is the structure of CD44? What is its function?

A

Expression: Activated B and T lymphocytes
Structure: Surface glycoprotein
Function: Cell adhesion

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25
Q

What are other names for CD45? Where are they expressed? What is the structure? What is its function?

A

Other names: Leukocyte common antigen (LCA)
Expression: CD45RA naïve T lymphocytes and CD45RO memory or activated T lymphocytes
Structure: Protein tyrosine phosphatase
Function:
Defective in T-B+NK- SCID

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26
Q

What are other names for CD46? Where are they expressed? What is its function?

A

Other names: Membrane cofactor protein (MCP)
Expression: All cells (no RBC)
Function: Cofactor for factor I-mediated cleavage Adenovirus receptor

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27
Q

What are other names for CD49? Where are they expressed? What is its function?

A

Other names: Very late antigen (VLA a–f)
Expression: WBCs
Function: Receptors for fibronectin, VCAM, and others in cell adhesion

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28
Q

What are other names for CD52? Where are they expressed? What is its function?

A

Other names: CAMPATH-1 antigen
Expression: Mature lymphocytes
Function: Target for alemtuzumab (Campath)—monoclonal antibody used in the treatment of CLL

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29
Q

What are other names for CD54? Where are they expressed? What is its function?

A

Other names: ICAM-1
Expression: WBCs
Function: Binds LFA-1 (CD50). Receptor for rhinovirus.

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30
Q

What are other names for CD55? Where are they expressed? What is its function?

A

Other names: Decayaccelerating factor (DAF)
Expression: Hematopoietic cells, epithelial cells, and cell matrix
Function: Binds C3bBb and C4b2a to accelerate decay of C3 convertase Deficient in paroxysmal nocturnal hemoglobinuria

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31
Q

What are other names for CD58? Where are they expressed? What is its function?

A

Other names: LFA-3
Expression: WBCs
Function: Binds CD2 and adhesion

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32
Q

What are other names for CD59? Where are they expressed? What is its function?

A

Other names: Protectin Complement regulatory molecule
Expression: All cells
Function: Inhibits MAC formation by binding to C8 or C9

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33
Q

What are other names for CD62E? Where are they expressed? What is its function?

A

Other names: E selectin, ELAM1, SELE
Expression: Endothelium
Function: Ligand for CD15s, CD44, and CD162 Leukocyte rolling Defective in LAD2

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34
Q

What are other names for CD62L? Where are they expressed? What is its function?

A

Other names: LECAM-1, SELL, L Selectin
Expression: B and T lymphocytes, and NK cells
Function: Lymphocyte homing to HEV of LN Binds CD34, CD15s,and MAdCAM-1

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35
Q

What are other names for CD62P? Where are they expressed? What is its function?

A

Other names: PADGEM, SELP, P Selectin
Expression: Platelets Activated endothelial cells (membranes of Weibel-Palade bodies)
Function: Binds CD162, rolling on activated endothelial cells Defective in LAD2

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36
Q

What are other names for CD64? Where are they expressed? What is its function?

A

Other names: FcγRI High affinity IgG receptor
Expression: APC (macrophages, neutrophils, eos)
Function: ADCC

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37
Q

What are other names for CD95? Where are they expressed? What is its function?

A

Other names: Fas Apo-1 TNFRSF6
Expression: Activated B and T lymphocytes
Function: Apoptosis when ligated by FasL Defective in ALPS

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38
Q

What are other names for CD106? Where are they expressed? What is its function?

A

Other names: VCAM-1
Expression: Endothelium, fibroblasts, and respiratory epithelium
Function: VLA-4 (α4:β1) α4β7 (act-1, LPAM-1)

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39
Q

What are other names for CD154? Where are they expressed? What is its function?

A

Other names: CD40L TRAP
Expression: T lymphocytes
Function: Regulates B lymphocyte function Expressed on T-cells Defective in XHIGM (X-linked hyper-IgM)

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40
Q

What is the CD marker for FcγRII?

A

CD32

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41
Q

What is the CD marker for CD40L expressed on T-cells?

A

CD154

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42
Q

What are other names for CD158? Where are they expressed? What is its function?

A

Other names: KIR (KIR2DL, NKG2A, and others)
Expression: NK and T
Function: Binds HLA class I and inhibits NK or T cell cytotoxicity

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43
Q

What are other names for CD159? Where are they expressed? What is its function?

A

Other names: NKG2A
Expression: NK
Function: Modulates NK killing

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44
Q

What are other names for CD162? Where are they expressed? What is its function?

A

Other names: P-selectin glycoprotein ligand-1 (PSGL-1)
Expression: Myeloid cells, Activated T lymphocytes
Function: Adhesion with endothelial cells

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45
Q

What are other names for CD178? Where are they expressed? What is its function?

A

Other names: CD95 ligand, FasL
Expression: Activated cytotoxic T lymphocytes
Function: Apoptosis Fas-expressing cells

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46
Q

What are the other names for CD4?

A

OKT4, CD223

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47
Q

What cells is CD4 expressed on?

A 
T Helper cells 
Monocytes 
Phagocytes 
Dendritic cells 
Langerhans cells Thymocytes
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48
Q

What is the % T-lymphocyte expression of CD4?

A

65%

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49
Q

What is the structure of CD4?

A

Ig Superfamily, Monomer

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50
Q

What is the domain-binding MHC of CD4?

A

beta-2

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51
Q

What are the function or biological properties of CD4?

A
  • MHC-restricted antigen induced T-lymphocyte activation
  • HIV receptor on T lymphocytes
  • Downregulated by HIV nef protein during infection
52
Q

What is another name for CD8?

A

OKT8

53
Q

What is the cell expression of CD8?

A

Cytotoxic T lymphocytes Cortical thymocytes
NK cells
Dendritic cells

54
Q

What is the % T-lymphocyte expression of CD8?

A

35%

55
Q

What is the domain binding MHC of CD8?

A

alpha 3

56
Q

What are the functions or biological properties of CD8?

A

MHC-restricted antigen-induced cytosis

57
Q

Where is the CD28 receptor located?

A

T lymphocytes

58
Q

What are the ligands for CD28? Where are they located? What is the function?

A

ligands: CD80 (B71), CD86 (B72)
Location: APCs (DC, macrophage, B lymphocytes)
Function: Costimulation or activation

59
Q

Where is CTLA4 (CD152) located? What are its ligands? Where are the ligands located? What is its function?

A

Location: Activated T lymphocytes
Ligands: CD80 (B71), CD86 (B72)
Location of ligands: APCs (DC, macrophage, B lymphocyte)
Function: costimulation or inhibition

60
Q

Where is ICOS located? What is the ligand? Where is the ligand located? What is its function?

A

Location: T lymphocytes
B-7 family ligand: ICOS-L
Location of ligand: APCs (DC, macrophage, B lymphocytes)
Function: costiumation

61
Q

Where are the B7-H1 (PD-L1) and B7-DC receptor located? What is its B-7 Family ligand? What is the location of the ligand? What is its function?

A

Location: DCs, macrophages, B lymphocytes
B-7 Family ligand: PD1
Location of ligand: B lymph, T lymph
Function: Inhibition

62
Q

What are the other names of CD16? What cells is it found on? What is the function? What is the ligand?

A

Other name (1): FcyRIIIA
Cell: NK cells
Function: ADCC
Ligand: IgG low affinity

Other name (2): FcyRIIIB
Cell: Neutrophils
Function: Phagocytosis
Ligand: IgG low affinity

63
Q

What are the other names of CD32? What cells is it found on? What is the function? What is the ligand?

A

Other name (1): FcyRIIB
Cell: B lymphocytes, dendritic cells, macrophages
Function:
Feedback inhibition of B cells, dendritic cells, macrophages
Ligand: IgG low affinity

Other name (2): FcyRIIA
Cell: Macrophage Neutrophils Eosinophils Platelets
Function: Phagocytosis
Ligand: IgG low affinity

64
Q

What are the other names of CD64? What cells is it found on? What is the function? What is the ligand?

A

Other name: FcyRI
Cell: macrophages, neutrophils, eosinophils
Function: phagocytosis
Ligand: High affinity IgG (IgG1, IgG3 and monomeric IgG)

65
Q

What cells is FceRI located on? What is its function? What is its ligand?

A

Cells: Mast cells, basophils, eosinophils, dendritic cells
Function: Degranulation, antigen uptake
Ligand: Monomeric IgE high affinity

66
Q

What cells is FceRII (CD23) located on? What is its function? What is its ligand?

A

Cells: B lymphocytes, eosinophils
Function: unknown
Ligand: IgE, low affinity

67
Q

Where is the TNF R1/p55 receptor found? What is its function? What is the ligand?

A

Cell: most cells
Function: apoptosis
Ligand: TNF (membrane bound and trimeric soluble forms)

68
Q

Where is the TNFR2/p75 receptor found? What is the ligand?

A

Cell: immune cells
Ligand: TNF (membrane-bound homotrimer form)

69
Q

Where is the LT-BR receptor found? What is its function? What is the ligand?

A

Cell: Epithelial cell Myeloid cells (Not B and T lymphocytes)
Function: apoptosis, IL-8 release
Ligand: TRAF, lymphotoxin

70
Q

Where is the Fas receptor found? What is its function? What is the ligand?

A

Cells: Activated B and T lymphocytes
Function: Apoptosis
Ligand: FasL

71
Q

Where is the CD40/CD134 receptor found? What is its function? What is the ligand?

A

Cell: activated T lymphocytes
Function: Second signal
Ligand: CD40L, TRAF

72
Q

Where is the OX40 ligand found? What is its function? What is the ligand?

A

Cell: Activate T lymphocytes
Function: Implicated in cytokine storm of H1N1
Ligand: TRAF

73
Q

Where is RANK found? What is its function? What is the ligand?

A

Cell: Osteoclasts, dendritic cells, some macrophages
Function: activation of osteoclasts
Ligand: RANK ligand, TRAF

74
Q

Which PID is associated with defective CD40 and which is associated with defective CD40L?

A

Defective CD40 = HIGM3 and defective CD40L = XHIGM

75
Q

What does the activating mutation of CXCR4 cause?

A

Phagocytic defect, WHIM (or wart, hypogammaglobulinemi a, infection, and myelokathexis) syndrome.

76
Q

What are the HIV coreceptors?

A

CCR5 adn CXCR4

77
Q

How does complement bridge innate and cell-mediated immunity?

A

Innate responses generate complement components, which bind to receptors on WBCs. Ligand-receptor interaction leads to signaling pathways, cytokine release, and engagement of cell-mediated immunity.

78
Q

What is the most potent complement receptor? What does it bind? What does deficiency of the complement that binds to this receptor lead to?

A

CR3 is the most potent complement receptor and binds iC3b, which is an opsonin like Ig. A hereditary deficiency of C3 will lead to defective phagocytosis of encapsulated bacteria and will present with autoimmune disease and repeated infections.

79
Q

What is the other name for CR1? What cells is it found on? What is its function? What is its ligand?

A

Other names: CD35
Cells: Monocytes Neutrophils T and B lymphocytes Eosinophils RBCs
Function: Phagocytosis
Ligands: C3b, C4b, iC3b

80
Q

What is the other name for CR2? What cells is it found on? What is its function? What is its ligand?

A

Other names: CD21
Cells: B lymphocytes, FDC
Function: B-lymphocytes activation, EBV receptor
Ligand: C3d, iC3b, c3dg

81
Q

What is the other name for CR3? What cells is it found on? What is its function? What is its ligand?

A

Other names: Mac-1, CD11b/CD18
Cells: Monocytes, Neutrophils, NK cells
Function: Phagocytosis, adhesion
Ligand: iC3b, ICAM-1, bacteria

82
Q

What is the other name for CR4? What cells is it found on? What is its function? What is its ligand?

A

Other names: p150.95, Cd11c/CD18
Cells: Monocytes, Neutrophils, NK cells
Function: Phagocytosis
Ligand: iC3b, ICAM-3

83
Q

What is the other name for CRIg? What cells is it found on? What is its function? What is its ligand?

A

Other names: Complement receptor of the immunoglobulin family
Cells: Macrophage in liver (kupffer cells)
Function: Phagocytosis
Ligand: C3b, iC3b, inhibits alternatie pathway convertases

84
Q

What cells is CCR3 found on? What is its function? What is its ligand?

A

Cells: Macrophage Eosinophils Basophils Th1 Th2 Airway epithelial cells
Function: Implicated in allergic disease
Ligand: CCL11 (eotaxin-1) CCL5 (RANTES) CCL7 (MCP-3) CCL8 (MCP2) CCL13 (MCP4) CCL26 (eotaxin-3)

85
Q

What cells is CCR4 found on? What is its function? What is its ligand?

A

Cells:
CD4 T lymphocytes DCs Basophil Macrophage Platelets
Function: T-lymphocyte trafficking
Ligands: CCL17 (TARC) CCL22 (MDC)

86
Q

What cells is CCR5 found on? What is its function? What is its ligand?

A

Cells: T lymphocytes Monocytes
Function: Cell trafficking. HIV coreceptor
Ligand: CCL3 (MIP 1α) CCL4 (MIP 1β) CCL5 (RANTES) CCL11 (eotaxin-1) CCL14 (HHC-1) CCL16 (HHC-4)

87
Q

What cells is CCR7 found on? What is its function? What is its ligand?

A

Cells: T lymphocytes, DCs (EBV-infected B lymphocytes)
Function: Naive T lymphocyte and DC trafficking to LN
Ligand: CCL19 (MIP-3B/ELC) CCL21 (SLC)

88
Q

What cells is CXCR4 found on? What is its function? What is its ligand?

A

Cells: Mature blood cells, blood progenitor cells, epithelial cells
Function: B lymphocyte development HIV co-receptor
Ligand: CXCL12 (SDF-1)

89
Q

What cells is CXCR5 found on? What is its function? What is its ligand?

A

Cells: B lymphocytes
Function: Home to B-T junction in LN
Ligand: CXCL13 (BCA-1)

90
Q

What is the function of XCR1? What is its ligand?

A

Function: T and NK cells recruitment
Ligand: XCL1 (Lymphotactin)

91
Q

What is the function of CX3CRI? What is its ligand?

A

Function: Recruits T, NK, and macrophages. Activates CTL and NK.
Ligand: CX3CL1 (factalkine)

92
Q

What do NK cells lack expression of?

A

CD3 and TCR

93
Q

Which complement receptor is also known as CD11c/CD18?

A

CR4

94
Q

What lymphocyte cell surface marker is present on memory B cells and absent on memory T cells?

A

CD27

95
Q

Which cells express MHC1?

A

All nucleated cells

96
Q

What cells express MHCI and MHCII?

A

B lymphocytes

97
Q

What cells express MHC II?

A

CD4 T cells

98
Q

What surface marker do switched memory B lymphocytes lose expression of?

A

Surface IgD

99
Q

What surface marker mediates homing to skin?

A

CLA-1 on T lymphocytes mediates homing to skin

100
Q

What surface marker mediates homing in on colonic tissue? How?

A

Α4β7 on T lymphocytes mediate homing in on colonic tissue by binding to MAdCAM-1.

101
Q

Where do naive lymphocytes home to? Where do activate lymphocytes home to?

A

Naïve lymphocytes home in preferentially on secondary lymphoid organs such as lymph nodes, spleen, and Peyer’s patches. This ensures a maximal probability of a diverse TCR repertoire coming in contact with unique antigens. Once activated, lymphocytes enter the circulation, whereby they encounter antigen residing in different tissues to elicit a strong memory response.

102
Q

What are the cell surface markers on naive B lymphocytes?

A

IgM/IgD

CXCR5

103
Q

What are the cell surface markers on naive T lymphocytes?

A

L selectin
CCR7
CD45Ra

104
Q

What are the cell surface markers on naive NK cells?

A

CD2

105
Q

What are the cell surface markers on activated B lymphocytes?

A

IgA
IgE
IgG
CD27

106
Q

What are the cell surface markers on activated T lymphocytes?

A 
CD40L (CD154) 
CD28 
CTLA4 
CD 25  
CD44 
CD45RO 
CXCR3 
CCR5  
HLADR
107
Q

What are the cell surface markers on memory B lymphocytes?

A

IgG
IgA
IgE
CD27+

108
Q

What are the cell surface markers on memory B lymphocytes?

A 
CCR7 
L-Selectin (CD62L) 
IL-7R 
IL-15 (CD8 only) 
CD44 
CD45RO 
MHCI 
CD27-
109
Q

What is the inhibitory cell surface receptor for B lymphocytes?

A

CD22

110
Q

What are the activating cell surface receptors for T lymphocytes?

A

IL-12 Rβ

IL-18 R

111
Q

What are the inhibitory receptors for NK cells?

A

NKG2A (CD94)
ILT-2
KIR

112
Q

What are the activating receptors for NK cells?

A 
CD16 
NCR 
KIR2DS 
CD92/NKG2C 
NKG2D
113
Q

What is the cell surface marker for monocytes or macrophages?

A

FcyR

114
Q

What is the cell surface marker for endothelial cells?

A

Selectins (CD62E)

115
Q

What is the cell surface marker for NKT cells?

A

Vα24-Jα18

Vβ11

116
Q

What is the cell surface marker for mast cells?

A

CD117 (c-KIT)

117
Q

What are dendritic cells divided into? What are the roles?

A

-Conventional dendritic cells (myeloid, lymphoid)
o Act as antigen-presenting cells

-Plasmacytoid dendritic cells
o Produce IFNα

118
Q

Why are cell surface markers so important? How does pathogenesis occur from defects?

A

Cell surface markers play an important role in cell function and survival. Clinical disease results as a defect in expression or in function, or by opportunistic use by a pathogenic organism.

119
Q

Are CD1a-3, CD11c, and CD11b present on conventional dendritic cells? plasmacytoid dendritic cells?

A

CD1a-3: high levels on conventional dendritic cells, negative on plasmacytoid dendritic cells

CD11c: high levels on conventional dendritic cells, negative on plasmacytoid dendritic cells

CD11b: variable levels on conventional dendritic cells, negative on plasmacytoid dendritic cells

120
Q

Which TLRs are present on conventional vs. plasmacytoid dendritic cells?

A

Conventional: TLR4, 5, 8
Plasmacytoid: TLR 7

121
Q

Is CD80/CD86 present on conventional dendritic cells?

A

Inducible

122
Q

Is IL T7 (CD85g) present on convetional dendritic cells? Plasmacytoid dendritic cells?

A

Conventional DCs: Negative

Plasmacytoid: High

123
Q

Is CD33 (Siglec-3) present on conventional dendritic cells?

A

High

124
Q

Is CD209 (DC sign) present on conventional dendritic cells?

A

High

125
Q

Is CMKLR1 present on convetional and plasmacytoid DCs?

A

Conventional DCs: high

Plasmacytoid DCs: in vitro expression

126
Q

Is TCL1 present on conventional DCs? Plasmacytoid DCs?

A

Conventional DCs: negative

Plasmacytoid DCs: high

First Aid Allergy and Immunology (68 decks)

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