Finals Flashcards
Endocrine chemical messengers are called
Hormones
Four classes of chemical messengers
Autocrine,
Paracrine,
Neurotransmitter, and
Endocrine
These are chemical signals produced by specialized cells,
secreted into the bloodstream and carried to a target tissue.
Hormones
Feedback Mechanisms
Increase in product leads to elevation of the activity and the
production rate
Positive Feedback
Feedback Mechanisms
Increased product leads to decreased activity in the
production rate
Negative Feedback
Types of Hormones
Hormones that diffuse through the plasma
membrane of its target cell and bind to a cytoplasmic
receptor or a nuclear receptor.In the nucleus, the
combination of the hormone and the receptor initiates
protein synthesis, described later in this chapter
Lipid-soluble
Types of Hormones
Hormones that bind to the external portion of
membrane-bound receptors, which are integral membrane
proteins on its target cell.
Water-soluble
Are sensitive to the environment of the body hence cells secrete hormones that control the substance of molecules
based on the bodies
Humoral Stimuli
Are regulated by action potentials which controls the body’s response to change such as hard rate or blood flow
Neural Stimuli
Occurs to hormones that stimulate the secretion of other
hormones in the body and in turn are also capable of
inhibiting its actions
Hormonal Stimuli
Hormones exert their actions by binding to target cell
proteins called
receptors
The portion of each molecule where a hormone binds is
called
receptor site
same chemical compositions are called
epinephrine
Summarize the mechanism of your nuclear receptors
Nuclear receptors activates nucleus to produce proteins through messenger RNA (mRNA)
cells stimulates itself
autocrine
stimulates nearby cells without entering the bloodstream
Paracrine
secreted into the bloodstream, by certain glands and
cells, then travel to their target
Endocrine
secreted by neurons into the synaptic cleft that activate an
adjacent cell
Neurotransmitter
The receptors that bind to DNA have fingerlike projections that recognize and bind to specific nucleotide sequences in the DNA called
hormone-response elements
The combination of the hormone and its receptor forms a
transcription factor
Summarize the mechanism of membrane-bound receptors
It attaches to receptors to activate G protein of your cell membrane to activate, again, the second messenger of the chemical messengers called Cyclic AMP (cAMP) to have stimulations on cells to produce more hormones
Derived from amino acids they are an intermediary between steroids and protein
Amines
Chains of amino acids that are synthesized and stored within the cell in the form of secretory granules and cleaved as needed
Peptides and proteins
Examples of Amines
Tyrosine, Thyroxine, Epinephrine, Norepinephrine
What type of Hormones are ACTH, ADH, Oxytocin, PTH, Prolactin, Somatostatin, MSH
Polypeptides
What type of Hormones are FSH, HCG, TSH, Erythropoietin
Glycoproteins
Give three examples of Protein
Insulin, GH, Calcitonin
What is/are the difference/s of Diabetes Mellitus from Diabetes Insp
- Affected by dietary consumption (Type 2)
- Autoimmune capability (Type 1)
● Lipid molecules that have cholesterol as a common precursor
● Produced by adrenal glands, ovaries, testes, and placenta
Steroids
Give some examples of Steroids
Aldosterone, Cortisol, Estradiol, Progesterone,
Testosterone, activated vitamin D3
secrete releasing and inhibiting hormones
Hypothalamic neurons
portal system for transport of hypothalamic hormones
Hypothalamo Hypophyseal
regulate the anterior pituitary
Hypothalamic hormones
travel to their targets
Anterior pituitary hormones
● Master gland
● Pea-sized but has a vital role
● Commands also other glands when to secrete hormones
● Asks signals from hypothalamus
● Maintain homeostasis; maintain equilibrium = either regulate or maintain
Pituitary Gland
Most abundant of all pituitary hormones.
Somatotropin
Growth Hormone
Functions of GH?
● Stimulate the growth of bones muscles and organs
● Stimulates says to produce insulin-like growth factors (IGF)
● Increase the rate of protein synthesis
○ metabolizes fat stores while conserving glucose
A decrease in GH is equivalent to?
Abnormal development of pituitary gland = Pituitary Dwarf
An increase in GH is equivalent to?
Hormonal secreting tumors Gigantism (acromegaly)
A pituitary lactogenic hormone, stress hormone, and a direct effector hormone
Prolactin
When Prolactin releases hormones, it will result in?
stimulation of production
Lesser production by the prolactin is a result of?
Inhibiting hormones
● Thyrotropin
● Binds to the thyroid glands
Thyroid Stimulating Hormone
The function of TSH?
Stimulates secretion and growth of thyroid hormones (T3 and T4)
Hypothyroidism is caused by
Destruction of the thyroid gland / Shrink thyroid glands and
secretes little thyroid hormone / Decrease in TSH
An increase in TSH will result to
Enlarged thyroid gland and secretes too much thyroid hormone = Hyperthyroidism
Stimulate melanin production in melanocytes to make skin
darker
Melanocyte-Stimulating Hormone
Hyperglycemic hormones
Glucagon and Cortisol
What are the result/s of the action of PTH
- Stimulation of calcium reabsorption in the blood
- Decrease loss of calcium ions in the urine
● Binds to receptors of adrenal cortex
● Increases the secretion of hormones from the adrenal cortex called cortisol
● Binds to melanocytes in the skin and increased skin
pigmentation
Adrenocorticotropic Hormones
When is Diurnal variation the highest and lowest
highest level between 6:00 AM to 8:00 AM and lowest between 6:00 PM to 11:00 PM
These are hormones that serve as important markers in diagnosing fertility.
Gonadotropin Hormones : LH and FSH
● Major function is to regulate water balance in the body
● Stops us to urinate
● Acts in the distal convoluted and collecting tubules of the
kidneys
● Conserves water; constricts blood vessels
Antidiuretic Hormone (ADH) / vasopressin
Decrease of ADH production causes
● Kidneys produce large amounts of water
● Diabetes Insipidus (polyuria)
What are some of the Inhibitors of ADH Release
Ethanol, cortisol, lithium, demeclocycline
● Binds to the smooth muscle cells of the uterus as well as milk let down from the breasts in lactating women
● Causes contraction of the myometrium of the uterus during labor
● Stimulated by nerve impulses from the hypothalamus as
cervix is stretched and as infants suck the nipple of the
mother
Oxytosin
● Located in the neck
● Butterfly-shaped organ
● Made up of two lobes connected by a narrow band called
isthmus
● Consists of follicular and parafollicular cells (C cells)
Thyroid Gland
Function of the Thyroid Gland
● Synthesizes and secretes T3, T4, and calcitonin
Most important element in the biosynthesis of
thyroid hormones
Iodine
Embedded in the posterior wall of the thyroid gland
Parathyroid Gland
Functions of the Parathyroid Gland
○ Increases active vit. D formation
○ Decrease loss of calcium ions in the urine
○ Promotes bone resorption
○ Secretes parathyroid hormone
An abnormally low rate of PTH secretion results in
hypopara-thyroidism
An abnormally high rate of PTH secretion results in
hyper-parathyroidism
Two small glands superior to each kidney
adrenal gland
● Inner part of the Adrenal Gland
● Secretes epinephrine (adrenaline or secondary amine
responsible for fight or flight) and norepinephrine
(noradrenaline which is highest concentration in CNS)
adrenal medulla
● Outer part
● Secretes steroid hormones
adrenal cortex
● Electro-regulating hormone
● The more that it secretes in the body, the lesser in the blood system (risky)
● The lesser that it secretes in the body, the more in the blood system
Zona glomerulosa: Mineralocorticoids (Aldosterone)
● It is the only adrenal hormone that inhibits the secretion of ACTH
● Hyperglycemic agent that increases the glucose level in the body
Zona Fasciculata: Glucocorticoid (Cortisol)
● Serves as precursor for the production of androgen and estrogen in tissues
● It is also the byproduct cortisol synthesis
Zona Reticularis: Adrenal androgens (DHEA)
Exhibit exocrine and endocrine functions
Pancreas
Released when blood glucose levels are low. binds primarily in the liver, causing glycogen (storage component of liver) stores to be converted into glucose
Alpha Cells ; Glugagon
Released when blood glucose levels are high
Beta Cells ; Insulin
Released in response to food intake. Inhibits the secretion of insulin and glucagon and inhibits gastric tract activity.
Delta Cells ; Somatostatin
● Most potent male androgen
● Synthesized by Leydig cells
● Promotes maturation of sperm
● Stimulates the development of secondary sex characteristics
● Promotes the closure of epiphysis of long bones
Testes ; testosterone
● Produced by the growing Grafiam Follicle
● Secreted in the ovaries prior the ovulation ; also produced in the placenta during pregnancy
● Secretion is regulated by FSH
● Involved in the enlargement of the uterus and breast during pregnancy
Estrogen
● Prepares the uterus for pregnancy
● Produced by corpus luteum
● Secreted in the ovaries after the ovulation ; also produced in the placenta during pregnancy
● Secretion is regulated by LH
● Involved in the reduction of contractility of the uterus ; stimulates the growth of mammary glands
Progesterone
● Lies in the upper part of the thoracic cavity
● Secretes a hormone called thymosin which aids in the
development of T cells
● White blood cells
Thymus Gland
● Small pinecone-shaped structure located superior and
posterior to the thalamus of the brain
● Secretes hormones called melatonin which plays a role in onset of puberty, controls circadian rhythm (sleep), and decreases the pigmentation of the skin
Pineal gland
Symptoms of Diabetes Mellitus
○ Polydipsia - excessive thirst
○ Polyuria - excessive urination
○ Polyphagia - excessive eating
Problem of insufficient ADH secretion from the posterior
pituitary gland.
Diabetes Insipidus
Autoimmune disorder in which antibodies are produced that activates the TSH recept
Grave’s Disease
● Hypercortisolism
● Increase of cortisol, normal or decrease of ACTH
Cushing’s Syndrome
● Decrease of T3 and T4, increase of TSH
● Caused by destruction or ablation of thyroid gland
Hashimoto’s Disease
● Caused by an ACTH-producing pituitary tumor
● Increase of cortisol, increase of ACTH
Cushing’s Disease
Is a connective tissue consisting of a variety of cells which are suspended in a fluid matrix called
Plasma
Composition of Blood
Plasma, Buffy Coat and Formed elements
Process that produces formed elements (rbc, wbc, platelets)
Hematopoiesis
Disk-shaped with thick edges that transport o2 to tissues
Erythrocytes
● Main component of erythrocytes
● Transports 𝑜2
Hemoglobin
Hemoglobin with an 𝑜2 attached
Oxyhemoglobin
explain the production of RBC
● Decreased blood 𝑜2 levels cause kidneys to increase production of erythropoietin.
● Erythropoietin stimulates red bone marrow to produce more erythrocytes.
● Increased erythrocytes cause an increase in blood 𝑜2 levels.
Cells that
● Lack hemoglobin
● Larger than erythrocytes
● Contain a nucleus
Leukocytes
Functions of WBC
● Fight infections
● Removes dead cells and debris by phagocytosis
● contain specific granules and include neutrophils,
eosinophils, and basophils
Granulocytes
- most common
- remains in blood for 10 to 12 hours then move to tissues
- phagocytes
Neutrophils
- reduce inflammation
- destroy parasites
Eosinophils
- least common
- release histamine and heparin
- response to allergens
Basophils
- no specific granules
Agranulocytes
- largest-sized white blood cells
- produce macrophages
Monocytes
- immune response
- several different types (T cells and B cells)
- lead to production of antibodies
Lymphocytes
minute fragments of cells, each consisting of a small amount of cytoplasm surrounded by a cell membrane.
PLATELETS
large cells are known as
megakaryocytes
When blood vessels are damaged, blood can leak into other
tissues and disrupt normal function.
blood loss
Temporary constriction of blood vessel
Vascular spasm
Can seal up small breaks in blood vessels
Platelet plugs
Blood clotting is also known as
Coagulation
Clotting Factor
● Proteins in plasma
● Only activated following injury
● Made in liver
● Require vitamin K
● Network of thread-like proteins called fibrin that trap blood cells and fluid
● Depends on clotting factors
Clot
Examples of Anticoagulants
heparin and antithrombin
● Condensing of clot
● Serum in plasma is squeezed out of clot
● Helps enhance healing
Clot Retraction
● Process of dissolving clot
● Plasminogen (plasma protein) breaks down clot (fibrin)
Fibrinolysis
UNIVERSAL BLOOD DONOR
o-
UNIVERSAL BLOOD RECIPIENT
ab+
WHOLE BLOOD
PLASMA + RBC
RBC’s ONLY
PACKED RBCS
Why is AB+ considered the universal recepient
AB+ is considered as the universal blood donor it’s PRBC’s
matches with both A and B, and the + RH type can accept a -
blood type AB+ is considered as the universal blood donor it’s PRBC’s matches with both A and B, and the + RH type can accept a - blood type
Provides information such as RBC count, hemoglobin,
hematocrit, and WBC count
Complete Blood Count (CBC)
This occurs when the mother produces anti-RH antibodies that cross the placenta and agglutination and hemolysis of fetal erythrocytes occur
Hemolytic Disease of Newborn
How can you prevent Hemolytic Disease of Newborn?
with RhoGAM
● Low white blood cell count
● Caused by radiation, chemotherapy drugs, tumors, viral
infections
Leukopenia