Finals Flashcards
The study of disease, but they involve different aspects of disease.
EPIDEMIOLOGY
Studies the factors that determine the frequency, distribution and determinants of diseases in human populations.
Epidemiologist
British physician, designed and conducted an epidemiologic investigation of a cholera outbreak in London
John Snow
The infectious disease is transmissible from one human to another (person to person)
Communicable disease
A communicable disease that is easily transmitted from one person to another.
Contagious Disease
The human acquires from animal sources
Zoonotic disease (zoonosis)
The number of new cases of that disease in a defined population during a specific time period
Incidence
Expressed as a number of new cases of a particular disease that occurred during a specified time period per a specifically defined population. (usually per 1000, 10,000 or 100,000 population)
Morbidity Rate
Prevalence is the proportion of a population who have a specific characteristic in a given time period.
Prevalence
Two types of Prevalence
- Period Prevalence
2. Point Prevalence
The number of cases of the disease existing in a given population during a specific time period
PERIOD PREVALENCE
The number of cases of the disease existing in a given population at a particular moment in time
Point prevalence
Refers to death
Also, known as death rate
MORTALITY RATE
The ratio of the number of people who died of a particular disease during a specified time period per a specified population
MORTALITY RATE
Occurs only occasionally within the population of a particular geographic area
Sporadic Disease
It is always present within the population of a particular geographic area
The number of cases of disease may fluctuate overtime but the disease never dies out completely.
refers to the constant presence and/or usual prevalence of a disease or infectious agent in a
population within a geographic area.
Endemic Disease
Greater than usual number of cases of disease in particular region usually occurring within a relatively short period of time
Refers to an increase, often sudden, in the number of cases of a disease above what is normally expected in that population in that area
Epidemic Disease (outbreak)
infectious disease occurs depends on many factors,
- FACTORS PERTAINING TO THE PATHOGEN
- FACTORS PERTAINING TO THE HOST
- FACTORS PERTAINING TO THE ENVIRONMENT
FACTORS PERTAINING TO THE PATHOGEN
Virulence of pathogens
Way for pathogen to enter the body
Number of organism that enter the body
FACTORS PERTAINING TO THE HOST
Health status
Nutritional status
Other factors pertaining to the susceptibility of the host
FACTORS PERTAINING TO THE ENVIRONMENT
Physical factors su8ch as geographical location, climate, heat cold humidity and season of the year.
Availability of appropriate reservoir
Sanitary and housing condition, adequate waste disposal
Any site where the pathogen can multiply or merely survive until it is transferred to a host.
RESERVOIR OF INFECTION (reservoir)
Includes human, household pets, farm animals, wild animals, certain insects, and certain arachnids (ticks or mites)
LIVING RESERVOIRS
Most important reservoir of human infectious disease is other human- people with infectious diseases as well as carriers.
Human Carriers
A person who is colonized with a particular pathogen.
CARRIER
SEVERAL TYPES OF CARRIER
- Passive carrier
- Incubatory carrier
- Convalescent carrier
- Active carrier
Carry the pathogen without ever having had the disease.
Passive carrier
A person who is capable of transmitting a pathogen during incubation period of particular infectious disease.
Incubatory carrier
Harbor and can transmitted a particular pathogen while recovering from an infectious disease
Convalescent carrier
Have completely recovered from the disease, but continue to harbor the pathogen indefinitely
Active carrier
Caused by Toxoplasmosis gondii, can be contracted by ingesting oocytes from cat feces that are present in litter boxes or sand boxes as well as ingesting cysts that are present in infected raw or undercooked meats.
Toxoplasmosis
May cause brain damage or death
Toxoplasmosis
Serve as reservoir of infections including insects and arachnids
Arthropods
These arthropods are referred to as
VECTORS
Inanimate reservoir of infection includes air, soil, dust, food, milk, water and fomites
NONLIVING RESERVOIR
Inanimate objects capable of transmitting disease.
Found within health care setting includes patients gown, bedding, towels, eating and drinking utensils and hospital equipment.
FOMITES
MODES OF TRANSMISSION OF PATHOGENS
- AIRBORNE
- DIRECT CONTACT AND INDIRECT CONTACT
- DROPLET
- VEHICULAR
- VECTORS
Involves contaminated inanimate objects such as foods, water, dust, and fomites.
Vehicular transmission
Are various types of biting insects and arachnids.
Vectors
Its mission is to promote technical cooperation for health among nations, carry out programs to control and eradicate diseases and improve the quality of human life.
World Health Organization (WHO)
Which assist the states and local health departments in the application of all aspects of epidemiology.
The overall mission is to promote health and quality of life by preventing and controlling disease, injury, and disability.
Center for disease control and prevention (CDC)
Pathogenic microorganisms sometimes wind up in the hands of mentally deranged people who want to use them to cause harm to others. And the microbes are biological warfare agents
BIOLOGICAL WARFARE
The member of terrorist or radical hate groups might use pathogens to create fear, chaos, illness, and death.
BIOTERRORISM agent
Four pathogens most often use:
- Bacillus anthracis
- Clostridium botulinum
- Smallpox virus (variola major)
- Yersenia pestis
Sources of water contamination
- Rainwater falling over the large areas collects in lakes and rivers that is subjected to contaminate by the soil microorganism and raw fecal material
- Groundwater from wells also can become contaminated
this are E. coli and other lactose fermenting members of family enterobacter and kleibsiella spp.
Coliforms
The sewage disposal plant, large debris is first filtered out called screening. Skimmers remove floating greases and oil and floating debris is shredded or ground
Flocculating substance can be added to cause other solids to settle out.
Primary sewage treatment
the material that accumulates at the bottom of the tank.
Primary sludge
The liquid called the primary effluent) then undergoes secondary treatment, which includes aeration or trickling filtration.
The remaining liquid is filtered and disinfected usually chlorination so that the effluent water can be returned to rivers or oceans.
SECONDARY Sewage Treatment
Where water in the short supply, the effluent water from the sewage disposal plant is further treated so that it can be returned directly to the drinking water system. This is very expensive process.
Involves the addition of chemical, filtration, chlorination and distillation.
TERTIARY S.T.
Any activity designed to study and or improve patient care outcomes in any type of healthcare institution or setting
Healthcare Epidemiology
ACQUIRED within the hospital or other health care facilities
Hospital acquired infection
NOSOCOMIAL INFECTION
Acquired outside healthcare facilities
Community acquired infection
caused 34% of Nosocomial infections in US
gram positive cocci
gram positive cocci bacteria
1) Staphylococcus aureus
2) Coagulase-negative staphylococci
3) Enterococcus spp.
Gram-negative bacilli bacteria
1) Escherichia coli
2) Pseudomonas aeruginosa
3) Enterobacter spp
4) Klebsiella spp.
Hard to treat as are infections caused by multidrug-resistant
Pseudomonas Infection
MOST COMMON TYPES OF NOSOCOMIAL INFECTIONS
- Urinary tract infection
- Surgical Wound infection (also referred as Postsurgical wound infections
- Lower respiratory tract infection (primary Pneumonia)
- Bloodstream infection (septicemia)
Gastrointestinal disease caused by
Clostridium difficile
a common member of the indigenous microflora of the colon where it exists in relatively small numbers.
Clostridium difficile
Clostridium difficile 2 types of toxins
- enterotoxin
2. cytotoxin
Causes disease known as antibiotic –associated diarrhea (AAD)
ENTEROTOXIN
Causes a disease known as pseudomembranous colitis (PMC)
Which section of the lining of the colon slough off, resulting in bloody stools
CYTOTOXIN
Father of handwashing
Father of hand disinfection
Father of hospital epidemiology
IGNAZ PHILIPP SEMMELWEIS
Support or monitor basic body function contribute greatly to the success of modern medical treatment
MEDICAL DEVICES
The single most important measure to reduce risk of transmitting pathogens from one patient to another or from one anatomic site to another on the same patients.
Handwashing
Pertains to the numerous measures that are taken to prevent infections from occurring in healthcare setting.
These preventive measures include actions taken to eliminate or contain reservoirs of infection, interrupt the transmission of pathogens and protect persons (patients, employees, and visitors) from becoming infected –in short, they are ways to break various links in the chain of infection.
INFECTION CONTROL
British surgeon, made significant contribution in the areas of antisepsis against infection and asepsis without infection
JOSEPH LISTER
Without infection includes any action taken to prevent infection or break the chain of infection
ASEPSIS
2 Types of ASEPSIS
- Medical
2. Surgical
Used for the care of all hospitalized patients, regardless of their diagnosis or presumed infection status
Incorporate the major features of universal precaution and body substance of isolation
STANDARD PRECAUTION
Designed to reduce the risk of transmission of blood borne and other pathogens in hospitals and apply to blood: all body fluids, secretions, and excretion except sweat, regardless of whether they contain visible blood: nonintact skin: and mucous membrane
STANDARD PRECAUTION
Used for routine handwashing, but an antimicrobial or antiseptic agent should be used in certain circumstances
Lathering hands should be rubbed briskly for at least 10-15 seconds
PLAIN SOAP (NONANTIMICROBIAL)
Worn when touching blood, body fluids, secretion, excretion, and contaminated items as well as just before touching mucous membrane or nonintact skin.
Gloves
Protects the wearer from large particles droplets that are transmitted by close contact and travel short distance
MASK, EYE PROTECTION, FACE SHIELD AND GOWNS
has become soiled with blood, body fluids, secretions, or excretion must be handled in a manner that prevents contaminating yourself or your clothing and prevent transfer of microorganism to other patients and areas
PATIENT CARE EQUIPMENT
The hospital must have and employees must comply with adequate procedures for the routine care, cleaning and disinfection of environmental surfaces, beds, bed rails, bedside equipment and other frequently touched surfaces
ENVIRONMENTAL CONTROL
Needlestick injury and injuries resulting from broken glass and other sharps are the primary manner in which healthcare professional become infected with pathogens such as HIV and HBV
OCCUPATIONAL HEALTH AND BLOODBORNE PATHOGENS
Involves either airborne droplet nuclei or dust particles containing a pathogen.
Small –particle residues (5um or less in diameter)
Airborne Precautions
Produced primarily as a result of coughing, sneezing and talking as well as during hospital procedures such as suctioning and bronchoscopy.
Droplets larger than 5 um in diameter
Droplet Precautions
The most important and frequent mode of transmission of nosocomial infections.
CONTACT PRECAUTIONS
separates sick people with a contagious disease from people who are not sick. Quarantine separates and restricts the movement of people who were exposed to a contagious disease to see if they become sick.
These people may have been exposed to a disease and do not know it, or they may have the disease but do not show symptoms.
ISOLATION
These isolation room are usually under negative pressure to prevent room air from entering the hallway when the door is opened and the air that is evacuated from such rooms passes through HEPA filters to remove pathogens
SOURCES ISOLATION
Among them are patients with severe burns, those who have leukemia, patients who have received a transplant ,immunosuppressed person, those receiving radiation treatment and luekopenic patients
PROTECTIVE ISOLATION
INCLUDES A PRIVATE ROOM IN WHICH vented air entering when the door is opened
The room must be thoroughly cleaned and disinfected before the patient is admitted.
All items coming from the patients must be disinfected or sterilized
TOTAL PROTECTED ENVIRONMENT (tpe)