Finalll!!! Flashcards
As an individual ages, the A. Vital capacity decreases B. Functional residual capacity decreases C. Expiratory reserve volume increases D. Residual Volume Decreases
A. Vital Capacity Decreases
During Exercise, the oxygen consumption (VO2), of the skeletal muscles may account for more than A.65% of the total VO2 B. 75% of the total VO2 C. 85% of the total VO2 D. 95% of the total VO2
D. 95% of the total VO2
The concentration of myoglobin in skeletal muscle is increased with high altitude natives
A. True
The max heart rate of a 55 year old person is
165 bpm
Most of the lung funtion indices reach their max level between
20-25 years of age
Acute mountain sickness is characterized by
Sleep disorders, Headaches, Dizziness, palpitation, Loss of appetite
At the onset of exercise, sympathetic discharge causes the
HR to increase, Peripheral vascular system to constrict, heart to increase its strength of contraction, blood vessels of the working muscles to dilate (all of the above)
During max exercise, the O2 diffusion capacity may
increase. (as much as 3 fold)
The O2 diffusion capacity of high altitude natives is about
20-25% greater. GREATER
The half life of carboxyhemoglobin when a victim is breathing room air at 1 atm is approx
5 hours
During exercise, an increase in heart rate accounts for a greater proportion of the increased CO than the increase in SV T/F
true
If a patient has a SaCO level of 20% how long will it take to reduce the level to 10% if he is breathing 100% oxygen
B. 5 hours
During pulmonary rehabilitation programs, the patient is evaluated by a variety of tests, such as PFTs, ambulatory oximetry studies, and nutritional, pyschological, lifestyle, etc... needs. this is done during what phase of the program A. Phase 1 B. Phase 2 C. Phase 3 D. Phase 4
A. Phase 1
Length and intensity of exercise is primarily limited by
Cardiac function
Indications of hyperbaric oxygenation might include
All of the above- Decompression sickness, Thermal burns, Clostridial gangrene, Carbon monoxide poisoning
A person in a high altitude situation develops crackles in the bases, pink frothy sputum and shortness of breath; which of the following lung conditions is occurring
Pulmonary edema
at the start of exercise, what is the FIRST physiologic response
Increased HR
The epithelial lining of the tracheobronchial tree is primarily composed of
pseudostratified ciliated columnar epithelium
Most of the mucus that lines the lumen of the tracheobronchial tree is produced by
Submucosal glands
Type II cells produce
Surfactant
Mast cells produce
Histamine
The first 19 generations of the lower airways are called the
Conducting zone and deadspace (where no gas exchange occurs)
Respiratory zone
last 4 generations
The visceral pleura lines the
lungs
The parietal lines the
thorax
The right and left main stem bronchi, blood vessels and nerves enter and exit the lungs through the
hilum
The phrenic nerve originates from what point of the spinal cord
Cervical 3-5
This opens and closes over the glottis to prevent aspiration of fluids/ solids during inspiration and expiration
Epiglottis
Which of the following have an important function in the immunologic response of pt with asthma A. Goblet Cells B. Type 1 cells C. Beta 2 cells D. Mast Cells
Mast cells- create histamine= bronchospasm (allergic reaction)
Anteriorly, the base of the lungs extends to about the level of which of the following ribs
6th
Ribs eight, nine, and ten are referred to as the
False ribs
True ribs
1-7
The area between the base of the tongue and the epiglottis is called
Vallecula
What function do the lympathic vessels in the lung perform
Fluid removal
Which one of the following would facilitate mucocillary transport and sputum clearance A. Dehydration (8hrs) B. Cig smoking C. Humidity D. Hypoxia
C. Humidity
The primary muscles of relaxed breathing are the
hemidiaphragms
The submucosal glands empty their contents when which of the following occurs?
A. The sympathetic nerve send a signal
B. The parasympathetic nerves send a signal
C. The voluntary motor nerves send a signal
D. Type II cells are stim
B. The parasympathetic nerves send a signal
The surfactant that is produced by the Type II cells in the alveoli main function is to
Reduce surface tension
The primary innervations of the hemidiaphragms is provided by the
Phrenic nerve
Stimulation of the heart by the parasympathetic nervous system will result in
The heart rate decreasing
Stimulation of the heart by the sympathetic nervous system will result in
The heart rate increasing
Muscles of inspiration
Pectoralis Major, Scalene, Sternocleidomastoids, Trapezius
Muscles of Expiration
Transverse abdominis, Internal intercostals, Rectus abdomonis, External intercostals
The point at which the trachea bifurcates into the right and left main stem bronchi is called the
carina
All the arteries in the body carry oxygenated blood to their destination T/F
False
In infants, this is the narrowest point of the upper airway
Cricoid cartilage
When lung compliance decreases
Ventilatory rate increases, Tidal volume decreases
Normal Tidal volume range is about
3-4 ml/lb
Deadspace
Ventilation without perfusion
Shunt
Perfusion without ventilation
Physiologic deadspace combination of
alveolar and anatomical deadspace
Surfactant is produced by which type of cells
Alveolar type II
Which of the following plays the greater role in causing Vent rate to increase in response to a dec PaO2
A. Carotid bodies
B. Aortic bodies
A. Carotid bodies
Alveoli falls below the critical closing pressure =
the alveoli will collapse
Apnea
Complete absense of spontaneous ventilation
Normal breathing
Eupnea
Cheyne-Stokes breathing
fast to slow to apnea breathing
Hypoventilation breathing
shallow/ slow
Increased alveolar ventilation
Hyperventilation
Biots breathing
Short episodes of rapid, uniformly deep inspirations, followed by 10-30 seconds of apnea
Rapid rate of breathing is called
tachypnea
Anatomical deadspace is estimated by using which equation
1ml/lb
Decreased alveolar ventilation
Hypoventilation
Cervical vertebrae 3-5
Where phrenic nerve originates from
Auto PEEP can cause A. Alveoli to collapse B. Air trapping and alveolar hyperinflation C. Increased lung compliance D. Decreased Raw
B. Air trapping and alveolar hyperinflation
Ten to thirty sec of apnea, followed by a gradual increase in volume and frequency of breathing, followed by a gradual decrease in the volume of breathing, until another period of apnea occurs is called
Cheyne-Stokes breathing
Normal Vd/Vt ratio is
25%-35%
The first 19 generation of the tracheobronchial airways are termed
Conduction zone
What readily diffuses the blood brain barrier
CO2
Type of breathing increases both the depth and rate of breathing to lower the PaCO2 and is commonly associated with diabetic ketoacidosis
Kussmauls breathing
A condition in which an indiv is able to breath most comfortably only in an upright position and commonly associated with severe COPD
Orthopnea
The peripheral chemoreceptors are significantly activated when the PaO2 decreases to about
60mmHg (hypoxic drive kicks in)
Which of the following centers control inspiration during normal breathing
Ventral
This area senses decreased O2 levels in the arterial blood and sends impulses to the resp center to increase ventilation
Peripheral Chemoreceptors
When airway resistance becomes high, to offset the increased work of breathing, pts vent. patterns is generally
Decreased RR and increased Vt
When you increase the I:E ration, you are doing what
prolonging the expiratory phase
If you have a COPD pt that is breathing at a RR=12bpm, with an I:E ratio of 1:3
Breath Cycle= 60/12= 5, Inspiratory 5/4= 1.25, Expiratory rate= 5-1.25= 3.75
Tidal volume
W x 1-5lb
Minute ventilation
RR x Vt
Ventilation deadspace
W x RR
Valv
Ve- Vd
In normal lungs, what is the amount of time needed for oxygen and carbon dioxide to reach equilibrium between the alveoli and the pulmonary capillaries
0.25 seconds
The peripheral chemoreceptors are special oxygen sensitive cells that react to reduction in
oxygen levels in the arterial blood
Whats the normal pressure of carbon dioxide found in the mixed venous blood of the pulmonary arteries (PvCO2)
46 mmHg
What would be a norm pressure of carbon dioxide found in the arterial blood (PaCO2) on an adult
40 mmHg
What would be a norm pressure of O2 found in the arterial blood (PaO2) on an adult
80-100 mmHg
Which of the following is NOT an ex of a clinical condition that decreases the rate of gas diffusion A. emphysema B. Asthma C. Pulmonary Edema D. Pneumonia
B. Asthma
Carbon dioxide diffuses A. at the same rate then O2 B. Twice as fast as O2 C. Half as fast as O2 D. 20x faster then O2
D. 20x faster then O2
The first 19 generations of the lower airways are termed the: I. Conductive Zone II. Respiratory Zone III. Anatomic Deadspace IV. Alveolar Deadspace
I. Conductive Zone and III. Anatomic Deadspace
Whats the ventilation to perfusion relationship in the upright lung, upper lung region (apex)
V>Q
V
Middle lobes
V=Q
Lower lobes
What is internal respiration
Gas exchange between the blood and the tissues (cells)
In the upright lung, blood flow is greatest through
lower lobes (gravity)
Blood flow and ventilation is best matched in what area of the lung
Middle lobe
Normal O2 consumption is equal to
250ml/min
Whats the partial pressure of H20 at 37 degree C
47 mmHg
What does the stimulated sympathetic nervous system cause to occur in the bronchial smooth muscle
bronchodilation
Which of the following causes blood to clot after an injury
Thrombocytes
A pt has a HR of 75 and a SV of 80ml what is their CO
6000mL= 6.0L/min
Normal CVP
0-8mmhg
Which of the following are most active in response to a bacterial infection
Neutrophils
Normal systemic arterial blood pressure is
120/80
If the meal arterial pressure falls below this value, there is inadequate perfusion to the brain and kidneys
60mmHg
Which of the following does NOT affect SV A. Preload B. Afterload C. Contractility D. Cardiac Index
D. Cardiac index
Cardiac Index equation
CO/BSA
Normal pulmonary artery pressure is
25/8 mmHg
An increase in which WBC indicates an allergic response such as asthma
Eosinophils
Inner lining of the heart is the
Endocardium
These vessels are referred to as resistance vessels and have the most influence on systemic blood pressure
Arterioles
60% of the total vascular blood volume is located in the
veins
The degree that the myocardial fiber is stretched prior to contraction best describes
Ventricular Preload
When the vascular resistance increases, the blood pressure
increases
This portion of the serous pericardium is on the surface of the heart
Visceral pericardium
Blood circulation through the heart
Superior and Inferior Vena Cava, Right Atrium, Tricuspid Valve, Right Ventricle, Pulmonary Valve, Pulmonary Artery, Pulmonary capillaries, Pulmonary vein, left atrium, mitral valve, left ventricle, aortic valve, aorta
Mean arterial pressure equation
Systolic+ diastolic x 2 divided by 3
CO divided by BSA
Cardiac index
The testing done to obtain volume and flow rate parameters, such as the FVC, FEV1, and FEF25-75
Spirometry
Flow is made up of what two components
Volume and time
Test to measure ability of gas diffusion across the alveolar capillary membrane is
DLCO
With norm lungs, comparing the SVC to the FVC should show that
A. The volumes are essentially the same
B. the flows are essentially the same
C. The FVC volume is larger then the SVC volume
D. The SVC flow is faster then the FVC
The volumes are essentially the same
Following the FVC maneuver that prod a flow/time curve tracing, you should be able to calculate the following measurements I. FVC II. FEV1 III. MVV IV.FEF 25-75 V. FEV1/FVC ratio VI.DLCO
I. FVC
II. FEV1
IV. FEF 25-75
V. FEV1/ FVC ratio
The volume of the FEV1 should be what % of the FVC volume
80%
What affects the prediction of normal lung volumes and flow rates
Age Height and gender
The reading is a good indicator of the patency of large airways
FEF 200-1200
MIP and MEP measure
muscle strength
What forced expiratory measurements reflects the status of the medium and small airways
FEF 25-75
The FEV1
The volume of air exhaled in the first 1 second of the FVC maneuver
In obstructive lung disease, the FEV1 and FEV1.FVC ratio are
decreased
Tests that can be performed to measure TLC
Helium Dilution, Nitrogen washout, and body plethysmography
Which portion of a FVC maneuver is referred to as “effort dependent”
first 30%
If a pt develops air trapping bc of obstructive disease, what volume will increase because of air trapping A. RV B. VT C. IC D. VC
A. RV
Restrictive lung disease will show up on a PFT as
low volumes
As a person norm ages , lung volumes and flow rates
decrease
Body pleth uses a modification of whos law to indirectly measure gases volumes in the lungs
Boyles law
The peak exp flow rate is the
fastest flow point in which air is forcefully exhaled
CaO2 formula
((Hbg x 1.34) x SaO2) + (PaO2 x 0.003)
CvO2 formula
((Hgb x 1.34) x SvO2) + (PvO2 x 0.003)
CcO2 Formula
(Hgb x 1.34 x1) + (PAO2 x 0.003)
Arterial Venous content formula
CaO2-CvO2
O2 ER
CaO2-CvO2/ CaO2
Oxygen Delivery (DO2)
CO x (CaO2 x 10)
O2 consumption formula (VO2)
CO x ((CaO2-CvO2) x 10)
Qs/ Qt (shunt)
CcO2-CaO2/ CcO2 - CvO2
Alveolar minute ventilation
Vt- Vd x RR
Normal CaO2 range is approx
18-20 vol %
CaO2- CvO2 is indicative of
Tissue uptake of oxygen
Which shift in the oxyhemoglobin dissociative curve is normally more clinically harmful to the pt
Left shift
A pt with a Hgb of 8.7 may potential have what type of hypoxia A. Hypoxic Hypoxia B. Anemic Hypoxia C. Circulatory hypoxia D. Histotoxic hypoxia
B. anemic hypoxia (not enough hgb to carry)
Each gram of hemoglobin can carry how much oxygen
1.34 ml
The normal antomical shunt is about
2-5%
Each heme group of a RBC can carr how many molecules oxygen
4
You have a post op pt that is sedated and sleeping. You note that their SaO2 is 89% on 1 lpm NC. You increase the liter flow to 5lpm and the SaO2 increases to 95%. this is an ex of
Shunt-like effect due to hypoventilation
A pt with a core body temp of 101.3 degrees F, will have a shift in the oxyhemoglobin dissociation curve to the
right
Metabolizing tissue cells consume approx___ of O2 produce approx ___ of CO2 at rest
250ml/min and 200ml/min
89% of the CO2 transport is provided by
RBC transport system
The single biggest carrier (63%) of CO2 is the
bicarbonate in the RBCs
an substance that dissociates completely into H+ and an anion is a
strong acid
Chemicals that neutralize acids and bases effect on the pH are called
buffers
pH normal range
7.35-7.45
PaCO2 normal range
35-45
HCO3 normal range
21-26
PaO2 normal range
80-100
Respiratory compensation can occur much quicker than metabolic (renal) compensation T/F
True
Common causes of Metabolic Acidosis might include
Lactic acidosis, Diarrhea, Ketoacidosis
The PaCO2 level increases with both acute and chronic hypoventilation. How can you tell the difference
A. The pH is within the norm range, and the HCO3 is increased , with chronic
B. The pH is low, and the HCO3 is norm, with acute
C. the pH is low, and the HCO3 is low, with acute
D. A and B
D. A and B
the pH of the human body is actually slightly
alkaloid
Hypoventilation acidic or alk?
Acidic
Hyperventilation acid or alk?
Alk
Respiratory compensation usually occurs in how much time when the pH begins to fall?
instantly