finale Flashcards
Shock
Inadequate cellular energy production caused either by poor oxygen delivery or increased cellular oxygen consumption.
Decreased oxygen delivery (DO2)
Diminished tissue perfusion
Increased oxygen consumption (VO2)
Increased cellular metabolism (heat stroke, sepsis, seizures/ tremors, etc.)
Why does energy production decrease?
No O2 = shift to anaerobic metabolism.
Determinants of DO2?
Cardiac output (HR+SV) x CaO2 (Hgb,SaO2,PaO2)
Shock Classifications
know about each – causes and clinical examples
Cardiogenic Hypovolemic Obstructive Distributive/ Vasogenic (“Call Help or Die”)
Shock Stages
know about each – clinical signs and outcome
Compensatory
Early Decompensatory
Decompensatory (Terminal)
How do Cats Differ?
Bradycardia, hypothermia, hypoglycemia, hypotension. Smaller blood volume than dogs.
Overall approach to shock?
Must identify and treat the underlying cause, and support patient to treat or prevent SIRS/ other complications.
Where are the following useful for shock treatment? Pressors Chronotropes Fluids Vasodilators Contractility RBC Transfusion Oxygen therapy
Pressors – Increase SVR Chronotropes – Increase heart rate Fluids – Increase preload Vasodilators – Reduce afterload Contractility – Increase strength of contraction RBC Transfusion – Increase hemoglobin Oxygen therapy – Increase dissolved O2
List monitoring parameters for shock (in order of clinical applicability)
Mentation MM color CRT Heart rate Pulse quality Blood pressure Urine output CVP Acid-base
Upper limits for shock dose of crystalloid and colloid? Know indications for each, and how to adjust if crystalloid and colloid are both used?
Crystalloid: Dogs 80-90 ml/kg, cats 50-60 ml/kg Colloid: Up to 20 ml/kg Administer ~25% of dose, reevaluate to treat to end points Hypertonic Saline: 4 ml/kg
Major drugs for inotropic and pressor support?
Dobutamine – Inotrope
Dopamine – Inotrope (lower dose) or pressor (higher dose)
Both given IV CRI
Define Systemic Inflammatory Response (SIRS)
A local problem causing systemic inflammation (infectious and non-infectious causes – be able to provide examples). Essentially, an overreaction to inflammation.
What are the major cytokines in SIRS?
IL1, IL6, IL8, TNF-alpha, Platelet activating factor