Final SG Flashcards
Gregor Mendel
Considered the father of modern genetics
William Bateson
First to use word “gene”
Archibald Garrod
Considered father of human biochemical genetics and pharmacogenetics (genetics and pharmaceutical interactions)
Charles Darwin
credited for the theories of evolution and natural selection
what method did Mendel use to demonstrate inheritance in pea plants that made it possible to identify the units of heritability?
he cross pollinated the plants himself, likely using a paint brush
if widows peaks are a recessive trait (allele=w) and no widows peak us a dominant trait (allele=W), then an offspring who inherits the genotype Ww will have a phenotype of
no widows peak
if widows peaks are a recessive trait (allele=w) and no widows peak is a dominant trait (allele=W), then the possible genotype combinations for offspring to inherit are: WW, Ww, wW, ww. How many phenotypes would one expect these four genotypes to code for?
2
allele
two copies/types of a gene for a trait
genotype
DNA coding for traits
Phenotype
observable physical characteristics produced by gene + environment
dominant allele
one or two alleles with a genotype for a trait results in the trait
Recessive allele
two alleles with the genotype are required for the trait to be expressed
A ? mutation for cystic fibrosis has been identified and sequenced, and is a candidate for gene therapy
single-gene or single-gene mutation
Huntington’s Disease (HD) is caused by a single-gene defect that causes involuntary movements of the hands and feet followed by the gradual loss of memory/cognitive skills, and ultimately, early death.
True of False: the onset of HD is usually between 20 and 40 years old.
False-onset is between 40 and 50 generally. this is an important point because it means symptoms appear AFTER childbearing years, making it harder to know if one risks passing it on to their children
single-gene mutations are believed to occur in [percent] of newborns
0.4%
the single-gene mutations involved in Duchene Muscular Dystrophy (DMD) impairs the production of [blank] , a protein involved in muscle contraction
Dystrophin
chromosomes
tightly wound strands of DNA that undergo mitosis and meiosis
molecule
smallest fundamental unit of a chemical compound that can take part in a chemical reaction
proteins
chains of amino acids, what comes together to cause traits
amino acids
building blocks of proteins produced by three codon pairs
genome
the complete set of genes or genetic material present in a cell or organism
what corresponds to replication of genetic material
meiosis and mitosis
T or F: DNA is stored in the nucleus of cells, whereas RNA can be in the nucleus or in other parts of the cell
True
transciption
the synthesis of RNA from DNA template (“opening the book”)
translation
the synthesis of amino acids sequences that make up proteins from RNA (“reading the book”)
mitosis
the process by which most cells in the body divide/replicate (making a copy)
meiosis
the process by which gametes (sperm and egg cells) are produced (“copying the book”)
what is true about humans
more genetic materials comes from mothers than fathers
according to the sugar text, most of the many ideas about aging can be organized into the following three theories of aging. which of the theories does sugar argues is best supported by the biological evidence?
evolutionary senescence theory
T or F: nobody knows why specific hairs turn gray or white and others do not, and at the present time, there is no known process to help cells continue producing their original color (sugar text)
true
mitochondrial theory of aging
energy-producing cell organelle is constantly hit with assaults and eventually fails to function
telomere theory of aging
DNA sequences at the ends of our chromosomes shorten with each replication
inflammation theory of aging
inflammation can damage tissues and cause cell death
immune theory of aging
the breakdown in the cellular and molecular defense mechanisms (DNA repair enzymes…) that is genetically controlled
evolutionary theory of aging
aging is the result from a decline in the force of natural selection, generally due to the life
free radical theory of aging
unstable molecules that want an extra electron will take it
what is the (disease) evidence for the telomere theory of aging?
cancer (immortal cells), Werner’s disease, Hutchinson-Gillford progeria
what are the (diseases) evidence for the inflammation theory of aging?
dementia, atherosclerosis, diabetes
issues older people have with temperature control, hypothermia, and heat stress are due to (blank) and (blank)
slower blood flow, less fat
the three main problems older people have with vision are:
farsightedness, cataracts, dry eyes
what does a population pyramid represent, and what are the MAIN/MOST important comparisons
centered count of number of people in a population by age and gender. it is used to compare developed and developing countries, and demands on public health infrastructure and medical care by different generations
telomere
specialized DNA sequences that are at the end of a chromosome that stabilize the chromosome
evolution
changes over time driven by heritable changes in DNA
natural selection
when given an organisms particular environment, a heritable trait increases or…
fitness
the ability to reproduce successfully, as measured by the number of an organism
behavior and lifestyle
50%
genetic
20%
social and environmental
20%
medical care
10%
T or F: phenotypes are determined by both environmental and genetic factors
true
sources of “risk factors”
health behaviors, environmental exposures
contemporary theories of health behavior can be broadly categorized as “cognitive-behavioral”, and apply to/use what three levels of influence on human behavior
community, individual (intrapersonal), interpersonal
examples of intrapersonal factors that influence individual-level behaviors
attitudes, skills, motivation, knowledge, self-concept, beliefs, developmental history, past experience
ways in which ACEs can impact health in adulthood
increased risk of mental illness, disrupted neurodevelopment, direct bodily damage, biological embedding, adoption of health risk behaviors
T or F: fetal alcohol syndrome is the second most common cause of preventable birth defects and developmental disabilities in the US
false
systematic review
summary of all research (that meets eligibility criteria) ona specific topic
meta-analysis
data from multiple studies re-analyzed to produce one pooled estimate
measure of association
a number showing how an exposure is related to an outcome/disease
odds ratio
odds of disease given exposure divided by odds of disease given no exposure
this relative risk of ADHD, 1.76, is interpreted as FAS patients are (what %) more likely to have ADHD compared to a non-FAS patient
76%
which hills postulate does a 76% increased chance of ADHD pertain to?
strength of association
which hills postulate for causality is represented by the fact that jones, ulleland, and burd all published studies that suggests alcohol consumption causes FAS…or similarly by the fact that 38 studies have examined relationships between ACEs and diabetes and 36 found an association
consistency
which two hills postulates for causality are represented by the facts that:
1. one of the ways in which we know alcohol consumption during pregnancy causes negative health outcomes for the baby is that alcohol impairs placenta-fetal blood flow resulting in hypoxia
2. as more alcohol is consumed by a mother, the level of hypoxia the fetus experiences increases
dose response, biological plausibility
a meta analysis was used to calculate the pooled odds ration for the association between exposure to four or more ACes and developing type II diabetes in adulthood.
interpret the results; OR=1.15, 95% CI=1.07-1.25
the odds of diabetes are 15% higher among those with 4+ ACE compared to those with none
T or F: according the the CDC, just over 1 in 10 adults in the US have diabetes. therefore your chance of getting diabetes is also 1 in 10.
false
according to CDC, approx. 1 in 3 American adults have pre-diabetes but losing weight by eating healthy and being more active can cut the risk of progressing to type 2 in half. therefore…
approx. 30% of American adults can reduce their risk of type 2 diabetes by 50% if they lose weight by eating healthy and being more active
where in the mothers body does alcohol impact the baby
placenta
alcohol is a (term) when consumed by pregnant women because it is a substance capable of disrupting fetal growth
teratogen
according to the quick guide to health literacy, strategies that help create user- friendly health websites that minimize confusion due to limited health literacy in the general population include
limit paragraph size, use bullets and short lists. use color or underline to identify links. include a simple search function. use meaningful headings. make web content printer friendly.
process whereby students learn by doing and by reflecting on the experience
experiential learning
the study of different teaching methods
pedagogy
blended learning where students are introduced to content at home and practice working through it at school
flipped classroom
Sickle cell anemia has an autosomal recessive inheritance pattern. Where in the world is sickle cell anemia the most common and why might that be?
why is Huntington’s disease used as evidence to support the Evolutionary theory of aging? use the words natural selection and fitness in your answer.
in your own words, please define what a “risk factor” is in public health and provide three examples. (address more than just behavioral risk factors)
list two examples of how health/mathematical literacy is important to an individual’s health
one type of virus called (blank) become part of DNA in the organism. About (blank)% of the human genome is thought to be from such viruses.
role of the RNA polymerase
to make more virus RNA
public health implication of RNA polymerase weakness
need yearly booster shot
genetic result of limitation of RNA polymerase
mutations because doesn’t proofread replication