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Spring Pharmacology > Final Review > Flashcards

Final Review Flashcards

1
Q

MC ADR with interferons

A

HA in 75%

Depression in 60%

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2
Q

Ribavirin can be used to treat Hepatitis ___

A

C

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3
Q

Timeline for protease inhibitors in treatment of Hep C

A

Telaprevir (Incivek) first 12 wks then stopped
Bocepravir (Victrelis) week 4 and onward
*always with ribavirin * peginterferon

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4
Q

recommended regimen for treatment of HIV/AIDS

A

viread +emtriva= Truvada

Isentress

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5
Q

What herpres medication can be PO, topical, or IV?

A

Acyclovir

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6
Q

Prevention of RSV with

A

Palivizumab (Synagis)

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7
Q

Prevention of rotavirus with

A

RotaTeq
live, oral pentavalent vaccine
3 dose regimen given 6-32weeks

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8
Q

multidrug resistant TB can use

A

Bedaquin (Sirturo)

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9
Q

What TB drug carries risk of optic neuritis?

A

Ethambutol

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10
Q

Active TB treatment profile

A

Rifampin x9m
Isoniazide x9m
Pyrazinamide x8w
Ethambutol x8w

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11
Q

Chloroquine is a

A

4-Aminoquinoline

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12
Q

Quinine sulfate & mefloquine are

A

4-Methanolquinolones

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13
Q

Primaquine is an

A

8-Aminoquinolone

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14
Q

Malarone is a

A

anti-folate

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15
Q

Antimicrobials that can be used as antimalarials

A

Tetracycline
Doxycycline
Clindamycin

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16
Q

MOA of metronidazole

A

interacts with DNA and loss of helical structure

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17
Q

What should be done when using Amphotericin B

A

pretreat with acetaminophen and corticosteroid

18
Q

Mineralcorticoids include

A

Deoxycorticosterone (Percoten V)

Fludrocortisone (Florinef)

19
Q

Only notable s/e of adrenergic agonists

Mirabegron (Myrebetriq)

A

HTN

watch for QTC elongation in pts with hx

20
Q

antimuscarinics/anticholinergics worsen what type of urinary incontinence

A

over flow

21
Q

Don’t use antimuscarinics in

A

GI obstruction
peptic ulcer disease
asthma
parkinsons

22
Q

….ateride

A

5 alpha reductase inhibitor

23
Q

….nafil

Tadalafil (Cialis)

A

Phosphodiesterase 5 inhibitor

24
Q

blue vision associated with Viagra and phosphodiesterase 5 inhibitor class is dt

A

PDE5 Inhibitor

25
Q

Tamoxifen (Nolvadex) is a

A

selective estrogen receptor modulator

26
Q

Anastrozole (Arimidex) is a

A

aromatase inhibitor

27
Q

Name an anti-HER2 agent

A

Tratuzumab (Herceptin)
Lapatinib (Tykerb)
Pertuzumab (Perjeta)

28
Q

who is a candidate for aromatase inhibitor

A

not if intact ovaries!

good for post-menopausal women

29
Q

notable ADR of ribavirin/ribasphere

A

hemolytic anemia

30
Q

name an neuraminidase inhibitor for PO and inhalation routes respectively

A

PO: Oseltamivir (Tamiflu)
Inhalation: Zanamivir (Relenza)

31
Q

Black box warning for Telaprevir (Incivek)

what would you be treating?

A

SJS

Hep C, first 12 weeks in combo with peginterferon & ribavirin

32
Q

In general HIV/AIDS drugs commonly interact with other drugs via

A

CYP3A(4)

33
Q

Generally best vehicle for derm

A

ointments

-oil in water emulsions MC

34
Q

Dermatologic topical corticosteroid affects

A

antiinflam
immunosupression of humoral factors
Antiproliferative
Vasconstriction

35
Q

Most potent corticosteroids

A

Class 1:
Clobetasol proprionate
Diflorasone diacetate
Halobetasol proprionate

36
Q

What diseases are highly responsive to corticosteroids

A

Psoriasis (intertriginous)
atopic dermatitis (esp kids)
seborrheic dermatitis
Intertrigo

37
Q

Adapalene cream is a

A

retinoid

38
Q

First line treatment for acne

A

Benzoyl peroxide

39
Q

ADRs of benzoyl peroxide

A 
Peeling
Stinging
Dryness
Erythema
Contact dermatitis
40
Q

Antibiotics for treatment of burns

A

Mafenide

*Silver sulfadiazine

Spring Pharmacology (9 decks)

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