Final Review Flashcards
Week 9
Genetic Diseases-Recessive
- both parents must have
-cystic fibrosis, sickle cell anemia, Tay-Sachs Disease, Thalassemia
Genetic Diseases-Dominant
-Only one parent may have
-Huntington’s Disease, Familial Hypercholesterolemia, Xeroderma Pigmentation
Teratogens
-causes birth defects
-effects depend on; length of exposure, amount of exposure, and time during development
-drugs, viruses, chemicals, and infection
-Most vulnerable during organogenesis (Weeks 3-8 Embryonic-Embryo- Development)
Teratogenic Drugs; TERA-TOWAS
T-Thalidomide
E-Epileptics (Valproic Acid, Phenytoin)
R- Retinoid (Vitamin A)
A- Ace Inhibitors/ ARBS
T-Third Element (Lithium)
O-Oral Contraceptives
W-Warfarin (Coumadin)
A-Alcohol
S-Sulfonamides/ Sulfones
Teratogens- TORCH Infections
T- Toxoplasmosis
Parv-O- Virus B19 (fifth disease)
R- Rubella
C-Cytomegalovirus
H-Herpes Simplex Virus
Embryonic/ Fetal Development
*Weeks 3-8-organogenesis
-3-8, heart-beats at wk. 4
-3-38, CNS (brain/ spinal cord)
-4-8, Arms/ Legs
-4-38, eyes
-6-38, Teeth/ palate
-7-38, external genitals
-4-20 ears
Menstrual Cycle-Ovarian Cycle-egg development
*maturation of ova
1) Follicular (makes estrogen) Phase (1st day menstruation, last 12-14 days)-help from LH and FSH
2) Ovulatory Phase (Starts when estrogen levels peak-ends w/ release of oocyte (egg)-12-36 hrs. LH surges, estrogen drops, progesterone rises
3) Luteal Phase-Starts after ovulation, last about 14 days-corpus luteum breaks down/ progesterone production ends (if not pregnant), menstruation starts
Menstrual Cycle-Endometrial Cycle
*changes in the endometrium of the uterus in response to hormonal changes during the ovarian cycle
1) Proliferative phase- occurs following menstruation and ends with ovulation, estrogen thickens uterine lining
2) Secretory phase- begins after ovulation and ends with onset of menstruation, lining thickens even more due to progesterone, no pregnancy lining breaks down
3) Menstrual phase- sloughing off and expulsion of the endometrial tissue (period)
Conception-Fertilization
*sperm reaches egg (outer fallopian tube). Fertilized egg (zygote- 46-chromosones needed for life to form)
For Conception to occur three things must happen
1) Ovulation- egg released into the fallopian tube
2) Sperm must be able to travel all the way up to meet the egg
3) One sperm must be able to penetrate the egg
Ones an egg is fertilized…
It becomes a zygote (one cell-cleavage), which travels to the uterus rapidly dividing along the way. On third day becomes a 16 cell sphere (marula). Day 5-blastocyst entering the uterus.
The blastocyst has 2 main parts
1) embryoblast-becomes the embryo
2) trophoblast- assist w/ implantation (occurs day 5 or 6), becoming part of the placenta
Progesterone
*thicken the uterine lining, makes it rich with blood which supports the developing embryo
The trophoblast once implanted into the uterus is then called the chorion
*the chorion releases enzymes to secure the blastocyst to the uterine wall
Primary Germ layer-develop around day 14 (three)
1) Ectoderm
2) Mesoderm
3) Endoderm
Organogenesis- Ectoderm (outer layer)
*Outer surface -epidermal cells of skin
*CNS-neuron of brain
*Neural Crest- Pigment of cell (melanocyte)
Organogenesis-Mesoderm (middle layer)
-dermis, bones, cartilage, muscles, kidneys, adrenal cortex, bone marrow, blood, and lining of blood vessels
Organogenesis- Endoderm (Internal Layer)
-creates mucosa of the esophagus, stomach, intestines, respiratory tract, liver, gallbladder, thyroid gland, and pancreas
Fetal Development (Week 9 until birth)
*organ system continue to grow/ mature
Fetal Circulation- oxygen is provided through the placenta not the lungs
1) Ductus Venosus - connects umbilical vein to the inferior vena cava.
2) ForamenOvale - opening between R and L atria, closes after birth-full closure can take up to 3 months-by pressure of blood from L. atrium
3) DuctusArteriosus- connects pulmonary artery with descending aorta, constricts (higher )2 levels/ prostaglandins)
Placenta Functions
Metabolic and gas exchange( oxygen and carbon dioxide), acts as liver/ lungs for the fetus, nutrients (glucose/ amino acids), electrolytes between mom/ fetus, removes fetal waste products, hormone production
The placenta produces several important hormones
1) Progesterone-helps w/ implantation/ reduces uterine contractions
2) Estrogen- promotes growth of breast/ uterus
3) HCG (human chorionic gonadotropin)- maintains the corpus luteum, secretes hormones until the placenta takes over
4) Human placenta lactogen- supports fetal growth regulating glucose availability and stimulates breast development for lactation
Amniotic Sac (bag of waters)
*embryonic membranes; amnion (inner layer-from embryoblast), chorion (outer layer-from trophoblast)
*function- hold embryo/ amniotic fluids, maintains sterile environments
Amniotic Fluid-first trimester (amniotic membrane produces), second/ third trimester- produced by fetal kidneys)
*mostly water, contains proteins, carbs, lipids, electrolytes, and fetal cells, lanugo, vernix caseosa
Amount of amniotic fluid
*34 weeks- 800- 1,000 mL
*At term- 500- 600 ms
Amniotic Fluid function
*cushions fetus, prevents the fetus from sticking to the amniotic membrane, fetal movement (aids in symmetrical/ musculoskeletal development, maintains consistent thermal environment for fetus
Amniotic fluid abnormalities
Polyhydramnios- 1500-2000ml
Oligohydramnios- <500ml at term or less than 50% reduction from normal amount at time of gestation.
Reproductive System (Antepartum)
1) breast
2) uterus
3) vagina
4) ovaries
Cardiovascular system (antepartum)
1) Cardiac Output increases 30-50%
2) Blood volume increases 40- 50%
Respiratory System (antepartum)
-Increase tidal volume (30-40%)
-Increased oxygen consumption (20-40%)
Integumentary (antepartum)
1) Chloasma
2) Striae Gravidarum
3) Linea Nigra
Physiological Changes in Pregnancy
*Estrogen/ Progesterone rises
*blood volume increase
*shallow breathing
*increased urinary output
*mood changes
*nausea/ taste changes
*loosened ligaments
* breast changes
*damaged skin
Preconception Education
*optimize health and wellness of person to have a healthy baby
*maintain a healthy weight (18.5- 24.9 normal BMI)-weight gain 25-25 Lbs. occurs during pregnancy
*avoid caffeine, high mercury fish, undercooked foods, unpasteurized products, and alcohol
*prenatal vitamins (folic acids)
*Exercise-walk, swim, stretch
Diagnosis of pregnancy (three signs)
*presumptive
*probable
*positive
Presumptive signs (early subjective signs)
*amenorrhea, N/V (common weeks 2-12), breast changes, increased blood flow (2-3 weeks), fatigue, frequent urination (hormone changes/ growing uterus pressing on bladder), quickening (18-20 weeks 1st time moms-fetal movement)
Probable Signs of Pregnancy (objective/ physiological changes)
*Chadwick’s sign (bluish purple area around vaginal area), Goodell’s sign (softening of cervix/ > vaginal discharge), Hegar’s Sign ( softening of isthmus-lower part of cervix), visible uterine/ Abd. growth, skin hyperpigmentation. darkening of areolas/ nipples, positive HCG test (urine/ blood)
Positive Signs of Pregancy
*only explained by pregnancy
*fetal heart beat (heard w/ doppler 10-12 weeks), fetal movement (felt5 by examiner-20 weeks), ultrasound (4-8weeks, w/ vaginal probe)
Naegele’s rule
*Firs day of last menstrual period, minus 3 months, plus seven days, plus one year
GTPAL
*Gravida-total # of times pregnant (do not get fooled by number of babies, still considered 1)
*Term- 37 weeks or more
*Preterm-20 weeks- 36 weeks/6 days
*Abortion-Ending before 20 weeks
*Living-currently living children
First Trimester (1-13 weeks)-Timing, Screenings, Labs, Education, Assessments
*Initial; Hx, Physical/ Pelvic exam, assessment of uterine growth
*Fetal Heart Tones-US/ doppler (10-12 weeks, 110-160 BPM)
*Lab/ Diagnostics; Prenatal Panel-Blood type with Rh factor, Hep B, RPR/VDRL, Rubella, HIV
*anticipatory guidance, monthly visits, physical/ emotional changes, signs/ symptoms to occur, what foods to avoid
Second Trimester (14- 26 weeks)
*Office visits every 4 weeks
*Confirm due date
*Anatomy Scan at 20 wks.-detailed US of fetus
*education on preterm labor/ other signs/ symptoms HTN
Screening for Gestational Diabetes (GDM) at 24-28 wks.
1-hour glucose tolerance test (GTT), if elevated (>140mg/dl) 3-hour GTT required
+GDM if 2 elevated readings
*At 28 weeks Rhogam, if Rh-negative/ antibody screen negative)
Third Trimester (27 weeks- delivery)
Assessment of fetal well-being
FHT, kick counts (at least 10 kicks in 2hrs.)
Pelvic examination
Leopold’s maneuver (ATI Video)
Nutritional follow-up
Screening for group B streptococcus 35-37 wks.
Laboratory tests
Client Education-classes, reassurance, family help, impending labor signs
Danger Signs During First Trimester
burning with urination
Severe vomiting (HG)
Diarrhea, fever/chills
ABD cramping/vaginalbleeding
Danger Signs Second/ Third Trimester
Edema of face/hands
Epigastric pain
Severe headache
Changes in fetal activity
Vaginal bleeding/leaking of fluid
ABD pain
Maternal Adaption to Pregnancy
Parity
Maternal age
Sexual orientation
Single parenting-most at risk for depression and difficulty adjusting
Multiple pregnancies
Socioeconomic
Abuse
Military deployment
Paternal/ Partner Adaption to pregnancy
*may feel anxiety/ conflicting emotions, societal expectation, parenting skills, health of partner, neglected, announcement phase (mixed emotions about news), moratorium phase (limited conscious thought of pregnancy), focusing phase (end, increased involvement), relationship syndrome, Couvade Syndrome
Family Adaption to Pregnancy in the home
Changing structures of the family
Eight stages in the life cycle of a family
Developmental tasks
Grandparent adaptation
Sibling adaptation
Maternal adaptation to pregnancy
Psychosocial adaptation to pregnancy complications
Clomid (estrogen modulator-for infertility)
Used during anovulation, a condition where the ovaries do not release an egg (ovum) during the menstrual cycle. It is a common cause of infertility, as without ovulation, pregnancy cannot occur.
Terbutaline (Brethine)
*Beta-2 Adrenergic Agent
*Stops/Prevents preterm labor
*Given IV/ SQ
*AE= tachycardia, pulmonary edema, SOB, palpitations, provide education about increased anxiety
Nifedipine (Procardia)
*CA channel blocker
*Stop/ prevent preterm labor & treat HTN
*PO
Oxytocin (Pitocin)
*Stimulates smooth muscle that stimulates contractions
*IV (adjust rate with labor assessment (up to 500 ml/hr)
Methylerglovine (Methergine)
*Ergot alkaloid – stimulate smoothmuscle to producecontractions.
*PO- 0.2 mg, IM 0.2 mg, IV should only be used in life threatening situations.
*Contraindication: HTN
Carboprost Tromethamine (Hemabate)
*Prostaglandin- stimulatesmoothmuscle
*IM 0.25mg (do not exceed 2mg).
*Indication uterineatony
*Contraindication: asthma/chronic pulmonary disease (vasospasm).
Antenatal Testing-Ultrasound
Abdominal and Transvaginal
*Transvaginal (detailed/ accurate)-first trimester; for obese or visual obstruction of uterus also
*Abdominal (later in pregnancy)-full bladder-elevates the uterus
*: fetus appropriate gestational age size, viability, position and functional capabilities., viability
Antenatal Testing-US-Umbilical Artery Doppler flow studies (noninvasive)
*Purpose- assess placental perfusion (lifeline), rate/ volume of blood flow
*dx. for: IUGR, poor placental perfusion, high-risk (HTN, DM, Multiples, PTL)
*explain, address ?’s, comfort, schedule follow-up
Antenatal Chorionic Villi Sampling (CVS)-biochemical testing
*Aspiration of a small amount of placental tissue for chromosomal, metabolic,or DNA testing (10-13 weeks-early)
*transvaginal with US guidance (speculum)
*risk-fetal loss, assess fetal/ maternal well-being w/ doppler (2x every 30 minutes) after procedure
Antenatal- Amniocentesis- biochemical testing
*Needle aspiration through abdominal wall into the uterine cavity to obtain amniotic fluid US guided.
*Genetic testing (16-18 weeks)/ genetic disorders, NTD, infections, gender ID
*Risks- trauma to fetus/ placenta= bleeding, preterm labor, maternal infection, miscarriage, Rh sensitization (administer Rhogam after if needed)
*Assess FHR, educate on warning signs to return, no lifting for 2 days
Antenatal Testing-Percutaneous Umbilical Blood Sampling (PUBS)- biochemical
*sample of fetal blood from umbilical vein
*test formetabolic and hematological disorders, fetal infectionand fetal karyotyping
*US guided, done if there’s a anomaly detection at 18 weeks
*risks similar to amniocentesis
*Terbutaline ready for UC to relax uterus
Antenatal- Maternal Serum Alpha-Fetoprotein (MSAFP) Screening
*Blood test for AFP - a glycoprotein produced by fetal liver, GI tract and yolk sac in early gestation.
*Performed at 16-18 weeks
*Increased AFP= neural tube defects
*Decreased AFP= trisomy 21 (Downs)
Antenatal Testing- Quad marker screening-biochemical
*Maternal blood screening for AFP (alpha fetoprotein), hCG (human chorionic gonadotropin), Estriol (estrogen), Inhibin-A (protein)
*Performed at 16-18 weeks for NTDs and trisomies (Downs/ NTD)
Daily Fetal Movement Count (Kick Count)
*Maternal record of fetal movement
*Performed after 28 weeks
*normal 10X in 2 hours
*any movement counts, keep hands on belly, stay still, quiet environment
Antenatal Testing- Nonstress Test (NST)
*External Monitoring (fetal well-being)
*performed for unsuccessful kick count and high-risk pregnancies (disease/ trauma)
*Done for 20 minutes (to 40)
*Reactive (reassuring); 15 beat X 15 seconds (>32 weeks) and10 beats X 10 seconds (<32 weeks)
*Nonreactive-insufficient accels. in 40 minutes, follow w/ BPP or US
Antenatal Testing- Contraction Stress Test- CST
*Similar to NST, but w/ contractions
*assess the ability of thefull-term fetus to maintain normal FHR inresponse tolabor
*Monitor FHR/ activity for 20 minutes, no UCs (nipple stimulation/ Oxytocin IV)
*Negative CST (good=no decels.)
*Positive CST (bad=late decels w/ 50% UCs)
Biophysical Profile (BPP)-points system
*US measurement of fetal status w/ an NST.
*Perform NST, then 30 min. of US.
*US for five indicators; FHR, breathing movements, fetal movements, fetal tone, amniotic fluid
*Reassuring (8/10), Equivocal (6/10), Nonreassuring (4/10), certain asphyxia (2/10)
The onset of labor
*True labor-regular contraction that increase in intensity which cause cervical dilation and effacement, if this does not occur= false labor
*ROM/ SROM/ AROM (provider)- no more cushion; date/ time-18+ prolonged ROM=risk for infection (chorioamnionitis), amount, color, odor, FHR/ response.
*Bloody should
First Stage of Labor
*latent (0-5 cm), active (6-10 cm)
*Monitor V/S, FHR, UCs, SVE, Fetal position/ descent
-latent; effaced, mild/ short UCs (q 5-30 min at 30-45 sec.), mild discomfort, cramps
-Active; effaced 80%+, UCs q 3-5 mins at 40-90 seconds. Monitor FHR (15-30 min, pit?), V/S Q 2 hrs., 1 hr. if ROM, SVE, comfort (pain, ice chips)
Second Stage (push!)
*starts w/ complete dilation-delivery of baby
*Latent (laboring down)-not pushing yet, active-pushing
*UCs Q 2-3 minutes (no more than 5 Q 10 minutes)
Third Stage of Labor
*Signs placenta is imminent; uterus rise (ball shape), umbilical cord lengthen, gush of blood.
*5-30 minutes after baby is delivered
*Administer uterotonics (oxytocin), uterine massage to help w/ delivery
Fourth Stage of Labor (beginning of postpartum period)
*Delivery-4 hours
*Stabilize maternal vitals, homeostasis
*skin-to-skin, uninterrupted first hour (golden)
*repair lacerations/ episiotomy, placenta intact?
Labor/ Delivery Discomfort Management- pain
*Nonpharmacological; relaxation, breathing techniques, muscle massage, light effleurage, is this helpful-touch or no go?, counterpressure (open hand sacral pressure), in water, warm/ cold packs, relaxation distractions, acupuncture/ acupressure, positioning (for pain/ cardinal movements), aromatherapy, support
*Pharmacological; IV meds (can cause resp. depression for both fetus/ maternal), anesthesia; local/ regional (During 2nd stage in the ischial spine, epidural (1st/ 2nd stage, most common, SE, urinary retention (catheter), hypotension-IVF bolus before or during, ephedrine), bleeding risks, consent, spinal block (cesarean), general (emergent, cesarean w/ no other options)
Fetal Monitoring External
*External; Leopold’s maneuver first, UC transducer (fetal head) for FHR assessment for well-being, toco on fundus (pressure change for contraction, not strength- mild, moderate, strong, measured w/ hand)
Fetal monitoring- -requires ROM
*FSE (fetal scalp electrode); presenting part- head, accurate electrical activity for FHR monitoring
*IUPC (intrauterine pressure catheter); contraction occurrence/ intensity/ resting tone, amnioinfusion, mm Hg
FHR influences
*utero-placental unit-main transfer of O2/ CO2, need adequate blood flow, sufficient placenta area, free flowing umbilical cord
*fetal ANS; parasympathetic < HR-vagal stimulation, sympathetic > HR
* baroreceptors-stress receptors (heart), detects pressure changes
*CNS; immature causing variation in baseline
*Chemoreceptors, changes in O2, CO2, and pH levels
*hormonal regulation
FHR pattern interpretation
1) FHR baseline
2) Variability
3) Accelerations
4) Decelerations
Variable Decelerations
Abrupt-< 30 seconds from baseline to nadir. Change maternal position, then NRB 10L O2, stop oxytocin, possible amnioinfusion
Accelerations
*Abrupt increase in FHR baseline, good!
*> 32 weeks 15 X15, < 32 weeks 10 X 10
Early decelerations
*Gradual decrease, nadir and peak contraction
*caused by fetal head compression
*no intervention, possible SVE-imminent delivery status