Final Review Flashcards
What is a drug?
Any substance that is has the effect of altering bodily functions
What are routes of administering drugs (absorption)?
Oral, sulingual/buccal, inhaled, topical (eyes, ears, nose, skin), vaginal, rectal, transdermal, injection (IV, IM, SC, IA)
What are drug factors of absorption?
Formulation, solubility, particle size, pH and drug ionization
What are host factors of absorption?
Motility of the gut, food in the stomach, vomiting/diarrhea, circulation to the site of adminsitration, surface area at the site of administration and degree of first-pass metabolism
What are the steps of the first pass effect?
1.Drug is taken orally
2.Drug enters GI tract
3.Active drug absorbed from stomach and SI
4.High blood concentration of drug is in hepatic protal vein
5.Low blood levels after passing through liver
What is the first pass effect?
A fraction of the dose administered that reaches systemic circulation in an unchanged state
Where are drugs distributed from?
Plasma, interstitial fluids, inracellular fluids, transcellular fluids (CSF, peritoneal, pleural) and fat
What organs do drugs affect first?
The brain
What factors affect distribution?
Mechanical (blood flow, barriers)
Biochemical (lipid solubility, binding to plasma proteins, accumulation in tissues, pH)
What is phase I of the metabolism of a drug?
Conversion to a polar metabolite (oxidaiton, reduction, hydrolysis)
What is phase II of the metabolism of a drug?
Coupling of drug with an endogenous substance
What factors affect metabolism?
Genetic, environmental, physiological (age, liver disease, renal disease, nutrition, alcohol, smoking)
Where are drugs eliminated from?
Kidneys, GI tract, exhalation, saliva
What are pharmodynamics?
Physilogical effects of drug on the
body
What is the lower limit?
Concentration that produces half the greatest possible effect
What is the upper limit?
No more than 5-10% of patients experience a harmful side effect
Where does the most alcohol get absorbed?
70-80% in the duodenum and jejunum
What are the effects to tylenol?
Analgesic and anti-pyretic
What are the pharmacokinetics of acetaminophen?
- High absorption in the small intestine
- Metabolism in the liver
- Time to peak, 10-60 minutes
- half life, 2-3 hours
What are the effects of NSAIDs?
Anti-inflammatory, anti-pyretic, anti-platelet and analgesic
What are the pharmacokinetics of NSAIDs?
- Absorbed rapidly by the stomach and upper small intestine
- Time to peak, 1-2 hours
- metabolized in liver
What are teh side effcets of NSAIDs?
stomach - nausea, apin gastritis
Kidneys - hypertension, fluid retention, renal failure
platelets - dysfunction
vessels - vasocontriction
tinnitus
What do NSAIDs do to injury?
- Inhibit protein sysnthesis and muscle repair/regeneration
- Inhibit of tenocyte proliferation and collagen formation
- Impairs bone healing??
What are some topical NSAIDs?
Diclofenac, indomethacin, and ketoprofen