final review Flashcards
Epimysium
surrounds entire muscle belly
Perimysium
surrounds bundles of fasicles
Endomysium
surrounds individual muscle fibers
Plasmalemma (cell membrane) [structure of muscle fiber]
fuses with tendon, conduction of AP, maintains pH, transports nutrients
Satellite cells [structure of muscle fiber]
muscle growth, development, response to injury/training
Sarcoplasm [structure of muscle fiber]
cytoplasm, assists with glycogen storage
Transerve (T-Tubules) [structure of muscle fiber]
extensions of the plasmalemma, carry AP deeper into muscle fiber
Sarcoplasmic reticulum (SR) [structure of muscle fiber]
Ca2+ storage
Myofibrils
muscle –> fascicle –> muscle fiber –> myofibril
Sarcomeres
basic contractile element of skeletal muscle, end to end for full myofibril length, distinctive striations
common boundary structure: z-disk
used for muscle contraction: shortening
Actin
thin filaments, shows up lighter under microscope, l-band contains only actin
Myosin
thick filaments, shows up darker under microscope, H-zone contains only myosin
Motor units
a- motor neurons innervate muscle fibers
Neuromuscular junction
site of communication between neuron and muscle
consists of synapse between motor neuron and muscle fiber
Excitation-Contraction
Coupling
- Action potential (AP) starts in the brain
- AP arrives at axon terminal of neuron, releases
acetylcholine (ACh) - ACh crosses synapse, binds to ACh receptors on
plasmalemma - AP travels down plasmalemma, T-tubules
- Triggers Ca2+ release from SR
- Ca2+ enables actin-myosin contraction
Relaxed state of muscles
- No actin-myosin interaction= no CB
- Myofilaments overlap a little
Contracted state of muscles
- Myosin head pulls actin toward sarcomere (power stroke)
- Filaments shorten
Sliding filament theory
After power stroke ends:
* Myosin detaches from active site
* Myosin head rotates back to original position
* Myosin attached to another active site farther down
Process will continue until:
* Z-disk reaches myosin filaments OR
* AP stops, Ca2+ gets pumped back into SR
Muscle Relaxation
AP ends, electrical stimulation of SR stops
Ca2+ pumped back into SR
* Stored until next AP arrives
* Requires ATP
Without Ca2+ , troponin & tropomyosin return to
resting conformation
* Covers binding site
* Prevents cross-bridge formation
Muscle fiber type I
slow twitch
Muscle fiber type II
fast twitch, fatigue quickly
type IIa- short, high intensity
type IIx- used for every day activities, short, explosive sprints
Pulmonary Circulation
- Sup/Inf Vena cavae
- Right atrium
- Tricuspid valve
- Right ventricle
- Pulmonary valve
- Pulmonary arteries
- Lungs
Systemic Circulation
- Lungs
- Pulmonary veins
- Left atria
- Mitral/bicuspid valve
- Left ventricle
- Aortic valve
- Aortabody
Myocardium
cardiac muscle, only has one fiber type (similar to type I), cardiac muscle fibers connected by intercalated discs
left ventricle
has most myocardium, must pump blood to entire body, thickest walls (hypertrophy)
Right coronary artery
- Supplies right side of the heart
- Divides into marginal, posterior interventricular
Left (main) coronary artery
- Supplied left side of the heart
- Divides into circumflex, anterior descending
Atherosclerosis
coronary artery disease
Intrinsic heart rate
100 bpm
SA node: cardiac conduction system
initiates contractional signal
* Pacemaker cells in upper posterior RA wall
* Signal spreads from SA node via RA/LA
* Stimulates atrial contraction
AV node: cardiac conduction system
delays/relays signal to ventricles
* Located in wall of RA, towards the center
* Delay allows RA/LA to contract before RV, LV
AV bundle: cardiac conduction system
relays signal to RV/LV
* Travels along interventricular septum
* Divides into right and left bundle branches
* Sends signal towards apex of heart
Purkinje fibers: cardiac conduction system
send signal into RV/LV
* Terminal branches of right and left bundle branches
* Spread throughout entire ventricular wall
* Completes ventricular contraction
Stroke volume (SV)
volume of blood pumped into one heartbeat
Ejection fraction (EF)
percent of EDV pumped
Cardiac output (Q)
Q = HR * SV
resting= 4.2-5.6 L/min
arteries
carry blood away from the heart