Final - FAF

Question 1

What is FAF

Answer 1

Non-invasive imaging technique

Detects fluorophores - naturally occuring molecules that absorb/emit light of specific wavelengths

Question 2

How FAF works

Answer 2

Light of specific wavelengths can be generated and detected with special filters via fundus camera or confocal scanning laser technology

• lipofuscin pigments
• ON drusen
• astrocytic hamartoma
• aging cyrstalline lens

Question 3

Use in clinics: lipofuscin

Answer 3

Hyper = sign of incr lipofuscin accumulation in RPE, may indicate degenerative changes or oxidative injury

Hypo = missing/dead RPE cells

Question 4

Why macula is dark on FAF

Answer 4

Incr ocular pigments (lutein, zeaxanthin) that absorb light

Question 5

3 structures that look darker in FAF

Answer 5

ONH
BVs
Macula

Question 6

AMD with GA

Answer 6

GA = loss of RPE -> severe impairment of photoreceptors -> very poor VAs
Inner layers intact, outer layers disappear (OCT)

Appears dark on FAF

A completely black spot => absolute scotoma

Question 7

Well known complication of neovascular/wet AMD that can be seen with FAF

Answer 7

RPE tear

Question 8

Summary slide

• FAF provides info on __
• helpful dx

Answer 8

Metabolic state and overall health of the RPE (and indirectly the PR layer)

GA in AMD, other retinal dystrophies
White dot syndromes, drug toxicities