Final Exam Study Guide - Summer 2015 Flashcards
Appetite Stimulants…
NE, GABA, Dopamine, Benzodiazepines, Propofol, Serotonin Antagonists
Benzodiazepines as appetite stimulants…
GABA agonists; Stimulate GABA –> Inhibit Satiety Center –> Increase appetite
Appetite Inhibitor…
Serotonin
Propofol as an appetite stimulant…
GABA agonist; indicated for short term use; caution in cats - Heinz body anemia is possible if used for >5 days
Serotonin Antagonists that stimulate appetite…
Cyproheptadine (Cats) and Mirtazapine (Dogs)
Cyproheptadine…
Serotonin antagonist; use in cats as an appetite stimulant; orally admin. - well absorbed (takes 2-3 days); side effects: sedation
Blocks serotonin –> Inhibits Satiety Center –> Increase Appetite
Mirtazapine..
Serotonin antagonist; used in dogs as an appetite stimulant; increases NE centrally; pharmacokinetics misunderstood; hard to dose in cats
Glucocorticoids as an appetite stimulant…
Prednisone
What is the side effect of concern when using Prednisone as an appetite stimulant?
polyphagia
The purpose of using Emetics…
control of vomiting; act on the Emetic Center and CRTZ (outside the BBB)
Peripherally acting Emetics…
Hydrogen Peroxide
Hydrogen Peroxide as an Emetic…
reasonable for dogs; do not use in cats - severe hemorrhagic gastritis
Apomorphine as an Emetic…
opioid - reversing the opioid does not reverse the vomiting; side effects: sedation and respiratory depression; effective for dogs - Do NOT use in Cats
Can be given in all routes including the conjunctival sac - can flush the eye to get rid of some of it.
Xylazine or Dexmedetomidine as Emetics…
alpha-2 agonists; more effective in cats than dogs
Cats have more alpha-2 receptors
If you give a cat oral Diazepam, what will you potentially cause?
Idiosyncratic hepatotoxicity
Repeated propofol administration in Cats can cause…
RBC injury and Heinz body anemia
B-Vitamins an an appetite stimulant…
in cases of Vitamin deficiency
Used as an appetite stimulant, Megestrol acetate is a…
synthetic progestin…use w/ caution!
Anabolic steroids as an appetite stimulant…
Stanozolol…use w/ caution!
CRTZ stands for…
chemoreceptor trigger zone
What receptors stimulate the CRTZ to stimulate the emetic center and induce vomiting?
serotonin, neurokinin, alpha-2, dopamine, and histamine
In the CRTZ, Cats have fewer receptors for…
histamine and dopamine
In the CRTZ, Cats have more receptors for…
alpha-2 and serotonin
Why should you not use hydrogen peroxide in cats to induce vomiting?
cats have a higher risk of mucosal damage
Centrally acting Emetics…
Apomorphine, Xylazine and Dexmedetomidine
What are Immunosuppressive drugs to consider?
High dose glucocorticoids, Antimetabolites, Azathiprine, Cyclosporine, Topical Tacrolimus
How do Antimetabolites work?
inhibit purine/pyrimidine synthesis –> inhibit DNA synthesis of lymphocytes –> block T-cell activation and response
Azathiprine…
Anti-metabolite Immunosuppressant; do NOT use in Cats; admin. orally; monitor CBC/Chem. for toxicities and side effects
If patients are able to tolerate Azathiprine, they show less side effects than when given…
Prednisone
Cyclosporine as an immunosuppressant…
- reduces T cell activation and response
- topically treats KCS (eyes)
- systemically treats perianal fistula
- used as an adjunct w/ glucocorticoids to treat IMHA
- cytokine inhibitor
Tacrolimus topical…
immunosuppressant; topically used to manage perianal fistula when Cyclosporine does not work (works on a different target)
-cytokine inhibitor
What is the most common adverse effect when administering chemo?
GI signs
If you see Adverse GI side effects in a pt. undergoing chemo, what do you do?
administer anti-emetics before/during treatment to decrease nausea
What are the adverse effects that can be seen when administering chemotherapy?
GI effects, Bone marrow suppression, Immunosuppression, Hair loss, Toxicity, Drug resistance/loss of efficacy, acute tumor lysis syndrome
When using Chemotherapeutic agents causing myelosuppression…what do you monitor?
CBC
Neutropenia is a common side effect of chemotherapy. What is the lowest neutrophil count called?
Nadir
What happens if you get severe neutropenia with chemotherapy?
prophylactic antibiotics may be started and/or you can delay the next chemo treatment
T/F - Animals undergoing chemo lose hair like humans do.
False. Hair loss is more common in breeds with continued hair growth; cats whiskers may fall out; shaved areas do not grow back well.
T/F - If you suspect extravasation when administering chemotherapeutic agents, immediately remove the catheter.
False. Leave that sucker in! You need to try and remove as much of the drug as possible. You can also locally infuse with saline +/- other substances and administer hot/cold packs.
What class of drugs potential provide analgesia?
Opioids and NSAIDs
The mechanism by which NSAIDs work…
Cyclooxygenase or COX-inhibitors
Why must you not use glucocorticoids and NSAIDs together?
Glucocorticoids work to reduce and influence the cyclooxygenase pathway like the NSAIDs do. Using these drugs together will increase the risk of adverse effects - GI Ulcers!
Pharmacokinetics of NSAIDs…
good absorption; IM and oral admin.; Hepatic metabolism (phase 1 and 2 reactions in the Liver)
Why do we not extrapolate dose rate or intervals of NSAIDs from 1 species to another?
Terminal-1/2 life carries between species
What are the Anti-Inflammatory effects of NSAIDs?
inhibit production of pro-inflammatory eicosanoids - concerned with COX-2
Tend to use NSAIDs in cases of…
acute inflammation and pain (NSAIDs have a greater affect on acute inflammation rather than chronic inflammation)
Some differences in using NSAIDs vs. Steroids…
no immunosuppression, no impaired wound healing, no delayed fibroblast functions with NSAIDs
How do NSAIDs result in Analgesia?
decrease prostaglandin sensitization of neurons
NSAIDs have Antipyretic effects but will not reduce…
NSAIDs reduce Fever but will not reduce hyperthermia or normal body temp.
How does Aspirin have anti-thrombotic effects?
irreversibly inhibit COX in platelets - increasing clotting time; TXA2 is a platelet aggregating agent (inhibited); PGI2 is an anti-aggregating agent (less inhibited)
COX-2 is expressed by a number of cancers. Using NSAIDs….
has been associated with improved outcomes. NSAID’s have anti-neoplastic effects
What NSAID is often used in transitional cell carcinoma and osteosarcoma?
Piroxicam
Commonly used NSAIDs…
carprofen meloxicam deracoxib firocoxib robenacoxib flunixin meglumine phenylbutazone aspirin peroxicam
What are the indications for use of Ophthalmic drugs?
Mydriasis/Miosis Decrease aqueous fluid production or IOP Increase tear production Decrease inflammation (glucocorticoids and NSAIDs) Treat Infections Analgesia
Why are topical preparations preferred for Ophthalmic drugs?
high local concentration, low systemic absorption; drugs reach the anterior chamber and less get into the posterior chamber; systemic drugs may not reach parts of the eye in sufficient concentrations
T/F - Ophthalmic drugs prepared as ointments have faster elimination.
False. Ophthalmic drugs prepared as ointments have SLOWER Elimination.
PSNS’s effect of the eye….
Miosis - contracts the iris sphincter m.; contraction of the ciliary body; lens accommodation for near vision; increases uveoscleral aqueous outflow
Pupil constriction
SNS’s effect on the eye…
Mydriasis - relaxation of the ciliary body; contraction of the iris dilator m.; aqueous humor formation; lens accommodation for far vision
Pupil dilation
When should you avoid using Miotic drugs?
Anterior uveitis or Anterior Lens Luxation
What are the Miotic drugs to know?
Parasympathomimetic Drugs…
Pilocarpine
Physostigmine and Demecarium
Echothiopate
Pilocarpine…
direct acting parasympathomimetic short duration of action miosis lasts 2-6hrs Txt: glaucoma diagnosis of parasympathetic lesions (CN III)
Physostigmine and Demecarium…
indirect acting parasympathomimetic (reversible cholinesterase inhibitor - narrower therapeutic index)
Physostigmine crosses the BBB
increases uveoscleral drainage up to 48 hrs
Demecarium is usually used as preventative in the contralateral eye (preventative care for glaucoma)
Echothiophate…
indirect acting parasympathomimetic - irreversible
long miosis duration - >12hrs
What are the Mydriatic drugs to know…
Parasympatholytic Drugs…
Atropine
Tropicamide
Phenylephrine
Atropine as an Ophthalmic drug…
direct acting parasympatholytic
onset in 1 hr; duration last 120+ hrs
causes cycloplegia - be careful in horses!
Indications: mydriatic-cycloplegia to reduce pain associated w/ corneal or iris disease (uveitis); can break up synechiaee (adhesions of the iris to the cornea or lens)
minimal systemic absorption
What patients should you not use atropine as an ophthalmic drug in?
Do not use Atropine in patients with Primary Glaucoma!
What are the reasons to be cautious when using ophthalmic atropine?
primary glaucoma
bitter taste - will cause cats to froth/foam at the mouth
cycloplegia may cause panic in horses
When you need an Ophthalmic drug that will dilate the eye for long periods of time, you pick…
Atropine
Tropicamide…
direct acting parasympatholytic
onset of action in 15-30 min.; duration 6-12 hrs
indications: dilate the pupil for ophthalmic (funduscopic) exam, used to prevent adhesions after cataract surgery
Ophthalmic Phenylephrine…
alpha 1 agonist
contract the iris dilator m. - mydriasis
perioperative use in cataract surgery - reduces post-synechiae formation
more often used to help diagnosis and txt of Horner’s syndrome
cardiovascular side effects
In cats and horses it is unlikely to cause adequate mydriasis alone.
What does decreasing aqueous humor formation do for the animal?
decreases IOP and is used for managing glaucoma
What “classes” of drugs reduce aqueous humor formation of the eye act on?
alpha-agonists
beta-antagonists
carbonic-anhydrase inhibitors
prostaglandin analogs
What are the alpha-agonists that reduce aqueous humor formation?
Brimonidine (alpha-2 agonist)
used in dogs for glaucoma txt
What are the beta-antagonists that reduce aqueous humor formation?
Timolol
minimal systemic bioavailability
used for glaucoma management - can cause a little miosis
What is Cosopt?
Timolol + Dorzolamide = Cosopt; gives a better control over aqueous humor
What are the carbonic anhydrase inhibitors that decrease aqueous humor formation?
Dorzolamide and Brinzolamide
Dorzolamide…
carbonic anhydrase inhibitor
used to treat glaucoma
Brinzolamide…
reversible inhibition of carbonic anhydrase which decreases aqueous humor formation
sulfonamide derivative!
What prostaglandin analog is used to decrease aqueous humor formation?
Latanoprost emergency drug for acute glaucoma txt helps drain the pressure in the eye increases uveoscleral outflow by stimulating FP receptors in the eye reduces IOP
Natural tear film is 3 layered, made out of…
mucin, water, lipid
Lacrimomimetic agents provide…
lubrication but do not perfectly replicate natural tears
Why do we prefer ointments to drops for artificial tear production?
ointments have prolonged contact time, less dilution, a slower breakdown by tears/enzymes and less drainage via the nasolacrimal duct
What are the lacrimogenics we need to know?
Cyclosporine (optimmune)
Tacrolimus
Lacrimogenic Cyclosporine…
used in the txt of canine keratoconjunctivitis sicca
BID topical application is required; lifelong
monitored by Schirmer’s tear test
causes local immunosuppression
The purpose of lacrimogenics is to…
increase tear production
Lacrimogenic Tacrolimus…
decreases T-cell activation
used in pts. that do not respond to cyclosporine
**potential link to cancer - wear gloves
**can be used topically to treat perianal fistulas
The purpose of Topical Corticosteroids used to treat eye issues…
manage inflammation and immune-mediated conditions (Non-infectious keratitis, uveitis)
What are the 2 topical corticosteroids used for eye issues…
Prednisolone and Dexamethasone
there is little systemic absorption with local application
When do you grab Topical NSAIDs for eye issues?
when a higher local concentration and lower systemic concentration is desired
Topical NSAIDs are used in…
management of uveitis and some keratitis; use to manage inflammation associated with cataracts (diabetic pts.)
What are the contraindications of topical NSAIDs?
corneal ulcers, glaucomas, or coagulopathies
What are the 2 topical NSAIDs mentioned from class?
Flurbiprofen and Diclofenac
What are the topical antimicrobial agents for eyes?
Polymyxcin and aminoglycosides
What are the uses of topical antimicrobial agents for eyes?
treat conjunctival and corneal infectious diseases
typically require frequent administration
What could be damaging to the eyes when using antibiotics?
damaging to epithelial cells or inhibitory to keratocytes and impair corneal healing or worsen deep corneal ulcers
-these drugs are often use to treat secondary infections
What drug is the local anesthetic for eyes?
Proparacaine
MOA for Proparacaine…
blocks Na+ channels to prevent axonal depolarization
What is Proparacaine used to treat?
used to decrease corneal sensation to allow diagnostic evaluation (tonometry) by “freezing” the eye or decreasing pain in the eye
What are the classes of respiratory drugs?
expectorants, mucolytics, and decongestants
Respiratory drugs improve…
clearance of material from the airways by stimulating cough and breaking up mucous
What expectorant has been used in equine med?
Guaifenesin
What decongestant has been used to relieve nasal congestion in horses?
Phenylephrine - causes local vasoconstriction in upper airways
T/F - In respiratory infections, you are most likely treating a pneumonia.
True
What Respiratory drugs have good concentration in the epithelial lining fluid?
macrolides, tetracyclines, fluoroquinolones
What respiratory drugs achieve good concentration in the interstitial space?
Beta-lactams and aminoglycosides
If you suspect a fungal respiratory infection by Blastomycosis, what drug do you treat with?
Itraconconazole
Respiratory fungal infections caused by coccidioidomycosis is often treated w/…
fluconazole
T/F - When treating respiratory fungal infections, it is common to see the patients get worse before getting better because the drugs work to slowly kill the infectious agents.
True.
Using antiviral drugs to treat respiratory infections are uncommon. What viral conditions may you treat for?
conjunctivitis and feline herpes
What anti-inflammatory drugs are used for treating respiratory issues?
Glucocorticoids Prednisone or Prednisolone (orally) Fluticasone Leukotriene inhibitors NK1 antagonists - Maropitant (Cerenia)
The purpose of Antitussives…
cough suppressant
What are some antitussive drugs to know?
Opioids
Hydrocodone
Butorphanol
Codeine and dextromethorphan
How do Opioids function as antitussives?
reduce the sensitivity of the cough-center to afferent stimuli (like irritation, stretch) via opioid receptors
What may Hydrocodone have in it that vets should be aware of?
may be formulated w/ homatropine or acetaminophen
Butorphanol has a (high/low) first-pass effect, causing it to have (higher/lower) oral bioavailability.
Butorphanol has a HIGH first-pass effect, causing it to have LOWER oral bioavailability.
What are the side effects of antitussives?
sedation, constipation or nausea
What classes of drugs are bronchodilators?
beta-adrenergic agonists
methylxanthine derivatives
anticholinergics
Where do bronchodilators work?
bronchioles
Bronchodilating drugs are not commonly used in treatment of…
pneumonia and pleural disease
What are the non-selective beta-adrenergic agonists of the bronchodilator drugs?
Epinephrine and Isoproterenol
Epinephrine and Isoproterenol bronchodilator drugs…
urgent, injectable drugs (not given orally)
used for short-term treatment of life-threatening bronchoconstriction (as in acute anaphylaxis)
will have beta-1 cardiac effects
Selective Beta-2 agonist bronchodilator drugs…
Albuterol Salmeterol Clenbuterol Terbutaline AeroKat, AeroDawg, AeroHippus
Albuterol…
Selective beta-2 agonist bronchodilator
inhalational route
rapid response (5 min.); can last hrs.
Clenbuterol…
selective beta-2 agonist bronchodilator
oral syrup used in horses to manage chronic airway disease (COPD)
not permitted in food production animals
Terbutaline…
human approved product used in animals to manage asthma
oral or injectable available
*Almost ZERO oral absorption in horses.
What are the metered-dose inhaler drugs?
AeroKat, AeroDawg and AeroHippus
have a spacer and a specialized mask!
used more in treatment of chronic respiratory disease in cats and horses because they are weird!
What are the primary effects of selective beta-2 agonists?
bronchodilation, may also stabilize mast cells and increase mucociliary clearance
less apparent effects: smooth ms. relaxation, hyperglycemia, hypokalemia, tachycardia, tremors or ms. cramps
With chronic use of selective beta-2 agonists, you may start to see resistance..then what?
increase dose, change drugs or use environmental management
When using Phosphodiesterase inhibitors you get…
bronchodilation, inhibition of mast cell degranulation and improvement of muciliary clearance; adverse effects may include respiratory stimulation resulting in increased heart rate, increased contractility, GI upset, skeletal ms. twitching and PU/PD
In patients with pulmonary hypertension, treat w/…
Sildenafil (Viagra) - a vascular smooth ms. relaxant
What respiratory drug is an analeptic and central respiratory stimulant?
Doxapram - used to assist with laryngeal examination in dogs/cats
In premature animals, Doxapram will…
increase surfactant secreted shortly after birth.
What is the overall goal in Endocrine Pharmacology?
regaining normal homeostasis
If our target for drug action is HYPO and we are wanting to replace endogenous substances what drugs do we consider?
For example: hypoglycemia, hypocalcemia, hypothyroidism, hypoadrenocorticism
Dextrose (hypoglycemia)
Calcium gluconate (hypo calcemia)
Levothyroxine (hypothyroid)
DOCP/Fludrocortisone and Prednisone (hypoadrenocorticism - Addison’s)
If you have hypocalcemia from low PTH, which drug do you choose?
Calcitriol/Vitamin D
-calcitriol is INDIRECT replacement
In instances where the target for drug action is HYPER (hypercalcemia, carcinoma, adenoma, etc.) you have 4 options…
- destroy the abnormal tissue to get rid of the source
- inhibit the production of the substance
- increase elimination of the substance
- inhibit function of the substance
In Endocrine Pharmacology, when you want to inhibit the production of the excess substance - particularly for hyperthyroidism, what drug do you choose?
Methimazole - will not affect the mass but will inhibit its production of thyroid hormone
What drug works to inhibit the production of excess substances from the adrenal gland?
Trilostane
If you want to rid the body of excess calcium…
saline diuresis is your method!
What are the therapeutic goals on Endocrine Pharmacology?
- determining if the homeostatic change was abrupt or slow and then reversing the change in a similar fashion
- establishing the urgency of correction
- ALWAYS LOOK AT THE PATIENT
(lol I think I am losing my mind at this point in making my Study Guide)
Goal of Hypothyroid treatment…
decrease T3 and T4 production by the thyroid gland
Levothyroxine Sodium generic names…
Soloxine, Synthroid
Levothyroxine AKA Soloxine…
preferred drug for txt of hypothyroidism in all species
oral or injectable
injectable is only for treating myxedema coma (rare)
Hypothyroidism is way more common in….
dogs!
Hyperthyroidism is way more common in…
cats!
Antithyroid Drugs…GO!
Thiourylenes like:
Methimazole (Tapazole - human approved)
Methimazole…
treats hyperthyroidism in cats
dose SID - BID
stable clinical effects achieved after 2-4 wks
stops de novo production of thyroid hormones - does not affect pre-formed hormone
Mild side effects of Methimazole…
transient or mild GI signs - inappetence, vomiting
lethargy
mild, transient hematologic changes
Major side effects of Methimazole…
idiosyncratic reactions: facial excortiation, hepatopathy and significant hematologic changes - agranulocytosis and thrombocytopenia
Methimazole is available in a transdermal formulation…tell me about it!
made by compounder; applied to inner ear - ear pinna
useful in badass cats who hate taking meds…so ALL cats!
or in cats who have GI disease….these cats are probably still evil
T/F - Using transdermal Methimazole eliminated the chances of idiosyncratic reactions and GI upset in hyperthyroid treatment.
FALSE!
What is the goal in treating periparturient hypocalcemia?
Just replacing lost calcium.
In primary hypothyroidism, calcium replacement therapy is short term and replacement of BLANK is initiated for long-term management.
Vitamin D!
What is weird about the dosing of Levothyroxine?
dose it in mg/m^2
Why is the dosing for Levothyroxine weird?
to reduce the risk of over supplementation or thyrotoxicosis (excessive T4 levels)
How do you monitor Levothyroxine levels?
Check/Measure their T4 levels
What are drugs that could interfere with T4 levels?
Phenobarbital, glucocorticoids (pred. and dex.), phenylbutazone, zonisamide and quinidine
What CS would you expect in acute hypocalcemia?
hyperesthesia/pawing at face, flaccid paralysis, seizures, hyperthermia, bradycardia
Periparturient hypocalcemia is AKA…
Milk Fever or eclampsia
Treatment of Acute hypocalcemia, what are you parenteral options?
Ca Gluconate and Ca Chloride
Because Ca Chloride is more caustic, it should never be given…
SC/IM or extravasated when given IV
Rapid IV administration of Ca can cause…
arrhythmias or cardiac arrest
Oral formulations of Calcium are…
Ca Carbonate and Ca Proprionate
In regards to Calcium…
Bones..
Kidneys…
Gut…
Bones STORE Ca
Kidneys EXCRETE Ca
Gut ABSORBS Ca
Hypocalcemia from HypoPTH…how do we treat?
Short-term: parenteral Ca - Ca Carbonate and Ca Proprionate
Long-Term: Replace Vitamin D via Calcitriol
T/F - Calcitriol is the most potent form of Vit D.
Truth!
Giving calcitriol works how?
significantly increases Ca reabsorption in the Gut and decreases kidney excretion of Ca
What is Milk Fever?
periparturient hypocalcemia - sudden increase in Ca usage for which the pt. cannot adapt rapidly enough –> associated with birth and lactation
Milk…YUMMM
What is the lifelong treatment for hypoparathyroidism?
VITAMIN D!!!
What do you do when you feel hypoglycemic?
EAT!!!! Particularly, eat small meals more often! FEED THE NEURONS!
You have a hypoglycemic patient…who do you call on for help?
Dextrose 50%
How do you give Dextrose 50%?
In IV boluses diluted 1:4
For extended IV use, you must dilute to a 5% solution or lower to prevent phlebitis
Can be given as CRI
What is the most commonly used emergency therapy drug for hypoglycemia?
Dextrose 50%
What happens if you give Dextrose 50% SubQ?
Tissue Irritation
Glucagon treats what?
Hypoglycemia as well! But, it is given IV and is used to treat insulin-induced hypoglycemia in dogs (but dextrose is more commonly used)
What is the most common disease causing clinically significant hyperglycemia?
Diabetes Mellitus
Diabetes Mellitus is…
a chronic metabolic disorder that is characterized by high blood glucose caused by insulin deficiency and/or resistance
What can cause transient hyperglycemia?
stresssssss like finals!!!!
Treatment of Hyperglycemia from Diabetes Mellitus involves…
a combo of diet, exercise and meds! (either oral hypoglycemic agents or injectable insulin)
Tell me about oral hypoglycemic drugs in cats…
only work in about 20-30% of cats
Side effects: hypoglycemia, GI effects - vomiting, elevated liver enzymes
Glipizide…
only useful in Type II diabetes
work by direct stimulation insulin secretion by the beta cells
only used in cats (20-30%) - stimulates pancreatic insulin secretion
adverse effects: significant Hypoglycemia
Hellur, I have hyperglycemia, what drug do I need?
Insulin!
What are the 2 preparations of insulin approved for veterinary use by the US FDA?
PROZINC
VETSULIN
Veterinary preparations of Insulin come as…
40 IU/mL concentration or “U40”
Human preparations of Insulin come as…
100 IU/mL concentration of “U100”
T/F - When using veterinary preparations of Insulin, it is ok to use human insulin syringes.
FALSE! Special syringes are required if U40 insulin is used!
What’s so special about Detemir?
Deter could be DETRIMENTAL to Dogs! It is significantly more potent in the canine! Canine insulin receptors are 4x more sensitive to this insulin than other insulins.
What are the short-acting insulins?
Regular Insulin AKA Humulin-R
Tell me about Humulin-R…
it is the ONLY insulin that can be given IV and as a CRI
-also given as intermittent IM inj. - - do NOT give a bolus
it is soluble/crystalline/neutral insulin
most commonly used for management of critical care pts (DKA, hyperosmolar, etc)
What are the intermediate-acting insulins?
NPH/Vetsulin and Humulin-N
What are the “good K9 starting insulins”?
NPH/Vetsulin and Humulin-N
Isophane or Neutral Protamine Hagedorn is complexed w/…
protamine
Vetsulin/Caninsulin is kinda cool…why?
There is an insulin pen for cats that allows you to give 0.5IU increments.
it contains porcine lent insulin in a zinc suspension
What is the long-acting insulin?
Prozinc (protamine zinc insulin), Glargine, and Detemir
Prozinc…
FDA approved insulin for cats
pharmacokinetics are shorter than expected in felines
only given Subq
shortest of the long-acting insulins
Glargine…
long effect due to acidic pH - gradual absorption
more used in cats
Only given SubQ
precipitants form - get longer absorption
Detemir…
more commonly used in canine pts.
also used in some cats
4x higher potency in canine pts.
What drugs act on the adrenal cortex?
glucocorticoids and mineralcorticoids
How do glucocorticoids exert their effects?
genomic and non-genomic mechanisms
What do genomic effects involve?
the binding of glucocorticoid to a receptor which alters gene expression through transactivation or transrepression; in the cytoplasm
What do non-genomic effects involve?
interaction w/ receptors within the lipid membranes of cells and can cause more rapid changes; in the membrane
Do you use glucocorticoids in diabetic patients?
No ma’am/sir you do NOT! They are antagonistic to Insulin!
What are the most common side effects of glucocorticoids?
PU/PD…decrease serum calcium (decrease GI absorption, increase renal excretion), decrease ADH secretion….increases GFR
How do glucocorticoids affect the musculoskeletal system?
loss of muscle mass and gaining abdominal body fat
muscle wasting and polyphagia
How do glucocorticoids affect the reproductive system?
potential teratogens
can inhibit spermatogenesis and ovulation
How do glucocorticoids affect the GI/Hepatic system?
can cause GI ulcerations by increasing acid secretion and decreasing mucus secretion
cause fatty liver (increased fat absorption and deposition into the liver)
Do glucocorticoids cause pancreatitis?
They were just removed from the pancreatitis list. It is not believed that they predispose patients to pancreatitis but do NOT directly cause it.
What are the immunosuppressive effects of glucocorticoids?
may have an impact on healing when given at higher doses and for long-term therapy
What are the clinical uses for glucocorticoids?
anti-inflammatory, immunosuppression and neoplasia
The most common ways to use glucocorticoids is…
in allergy patients…atopic dermatitis, asthma, etc.
Higher doses of glucocorticoids are used…
longer term for immune-mediated and autoimmune conditions like immune-mediated thrombocytopenia (IMT) and inflammatory bowel disease (IBD)
Glucocorticoids have an effect on certain WBCs, making them useful adjuncts or palliative treatment for…
neoplasms, particularly round cell neoplasias: lymphomas, multiple myeloma and mast cell tumors
Steroids that require hepatic activation may show reduced..
potency in individuals w/ liver dysfunction
The duration of action of glucocorticoids is determined by…
the base steroid
What are the short-acting steroids?
hydrocortisone, prednisone, prednisolone, methylprednisolone
What time frame are short-acting steroids working with?
What time frame is Triamcinolone working with?
24-48hrs
What are the long-acting steroids?
Betamethasone and dexamethasone
What time frame are the long-acting steroids working with?
> 48hrs
Repeated dosing of Dexamethasone would result in…
accumulation.
What is the formulation of glucocorticoids?
salt esters and insoluble esters
What are the salt esters we should know?
Na phosphate and Na succinate
What are the Insoluble esters we should know?
acetate, acetonide, pivvulate
What is so special and cool about salt esters?
It allows for IV injection of larger volumes.
Dexamethasone sodium phosphate is an example of…
In practice, it is commonly referred to as…
a salt ester…
Dex SP
T/F - Insoluble esters may be administered IV, IM, SubQ, Intralesional, and Intraarticular.
False! Insoluble esters are NOT FOR IV use!
What are 2 examples of insoluble ester drugs?
Methylprednisolone acetate (Depo-Medrol) and Triamcinolone acetonide (Vetalog)
T/F - Glucocorticoids may be given orally or parenterally and are highly plasma protein bound.
True!
Prednisone must be hydrolyzed to BLANK to release the steroid base.
Prednisolone
Cortisone must be hydrolyzed to BLANK to release the steroid base.
Cortisol
Methylprednisone must be hydrolyzed to BLANK to release the steroid base.
Methylprednisolone
Glucocorticoids should NEVER EVER be used with…
NSAIDs
What happens when you use Glucocorticoids and NSAIDs together?
Increase the risk of GI Ulcers - potentially fatal complication
What are the side effects of short-term therapy wi†˙ glucocorticoids?
PU/PD/PP (polyphagia), stress leukogram
more sever effects are seen in pregnant animals - fetal abnormalities and abortion
What are the side effects of long-term therapy of glucocorticoids?
immunosuppression and increased susceptibility to infection, collagen disease - cruciate injuries, dermatologic changes, hypertension, thromboembolic disease, delayed wound healing, Addisonian signs
What do you risk with acute withdrawal of long-term glucocorticoid therapy?
Iatrogenic Addisons
What is the endogenous mineralocorticoid?
Aldosterone
Aldosterone is regulated through the…
Renin Angiotensin-Aldosterone system
What drugs do we use to treat hypoadrenocorticism?
Desoxycorticosterone Pivalate (DOCP) Fludrocortisone
T/F - DOCP has no anti-inflammatory component.
Truth!
What is the most commonly used mineralocorticoid?
DOCP
How is DOCP administered in canines?
Given IM every 25 days
How do you monitor DOCP/Hypoadrenocorticism?
Checking Serum Na+ and K+ levels
How is Fludrocortisone different from DOCP?
more potent w/ mild anti-inflammatory/glucocorticoid effects
given orally BID
How do you monitor Fludrocortisone/Hypoadrenocorticism?
Checking serum Na+ and K+ levels
Bromide cause BLANK in cats..
ASTHMA
If you give Propofol to a seizing pt. you must also…
intubate
Anti-epileptics that must be loaded…
Phenobarbital, Leveteracetum, or Bromide
Zonisamide…
rapidly enters the CNS
MOA of Phenobarbital…
potentiates GABA; Cytochrome p450 induction
MOA of Bromide…
competes with a Chloride transporter
Bromide…
requires loading; used in dogs; if dog on high salt diet, you need a higher dose/double dose; higher Cl- levels in bloodworm; ok for pts. with RENAL disease
Bromism toxicosis SE’s..
blindness, paresis, coma, megaesophagus; give fluids w/. furosemide
Leveteracetum…
hydrolyzed in serum and other tissues - safe in Liver diseased pts.; given IV for status epileptics; gets into CNS rapidly; tid or qid dosing; HONEYMOON effect!
Which epileptic can be given as CRI?
Midazolam
MOA of Zonisamide…
potentiates GABA…
Zonisamide…
sulfa; induces Liver enzymes - double the dose in pts. who are on Phenobarb
Opioids metabolized by the liver…
lidacaine, bupivacaine, mepivicaine, ropivacaine
Opioids Metabolized by plasma pseudocholinesterases…
procaine, and proparacaine
Increase dose by adding…
volume
Increase potency by adding…
lipid and water
Onset of analgesia is contributed to…
placement, concentration and drug factors
Local infiltration…
peripheral nerve block, intra-articular, epidural/intrathecal
Adverse effects of analgesics..
CNS stimulation, CNS depression, Cardiovascular depression, local irritation, methemoglobinemia (benzocaine and prilocaine), Histamine release (procaine and proparacaine)
Procaine…
esther; slow onset/short duration; metabolized to Paba; poor penetration to MM; TOXIC TO HORSES
General Lidocaine…
lrg. animal; metabolized by the liver; onset is 5 min/lasts an hr.; Sheep are most sensitive; cats more sensitive than dogs; 4mg/kg
Systemic Lidocaine…
class 1B anti arrhythmic; CRI anti-inflammatory for post-op ileus; in MLK drips
Local Lidocaine…
injs. are 1-2% solutions; can mix with bicarb to reduce irritation; topically is 4% soon. in gels, sprays and patches
EMLA cream…
2.5% lidocraine and 2.5% prilocaine; methemoglobinemia is possible but w/ lower toxicity
Bupivacaine…
metabolized in liver; 0.5% soln for inj.; 20 min. onset/ 8 hr duration; more potent than Lidocaine; 2mg/kg; more cardiodepression w/ diazepam
Mepivacaine…
liver metabolism; used more in nerve blocks
Proparacaine…
Liver metabolism; 30 s onset/20 min. duration; topical; used in eye exams
Which NSAID is COX-1 selective?
Aspirin - does not do anti-inflammatory
COX-2 selective NSAID?
Peroxicam
3, nonselective NSAIDs..do both COX-1 and CPX-2
flunexin meglumine (the only one approved in cattle - more for visceral pain)
phenylbutazone (used for musculoskeletal pain)
ketoprofen
COX-2 preferential NSAIDs..
carprofen, meloxicam (only given once in cats), deracoxib
COX-2 selective NSAIDs are the best…who are they?
Robenacoxib (used in cats for 3 days), firocoxib (for dogs but ppl use it in horses bc it’s much cheaper and really good!)
Aspirin…
COX-1 selective and anti-thrombotic
Flunexin meglumine…
bovine respiratory and mastitis
what NSAIDs do you not give IM in horses…
Flunexin meglumine or phenylbutazone
NSAID to treat Musculoskeletal pain in horses…
phenylbutazone…
NSAID administered IV or PO only…
phenylbutazone
Other anti-inflammatories…
Tramadol (opioid, weak mu agonist)
Chondroprotectives - glucosamine, omega 3 fatty acids, etc.
Omantidine (adjunct)
Cerenia
Which antitussive has a high first pass effect…
butorphanol
2 anti-congestants in horses…
Guaifenesin and Phenylephrine
2 Non-selective beta adrenergic agonists…
Epinephrine and Isoproterenol
Clenbuterol…
oral syrup used to treat COPD in horses
Albuterol or Salmeterol…
inhalant that is rapid and that lasts hrs.
Terbutaline…
small animal asthma drug
Methylzanthine derivatives are used to manage…
respiratory distress
Aminophylline and Theophylline
What drug is a respiratory stimulant to assist in pharyngeal exam…
Doxapram
Selective Beta 2 agonists…
-erols
Non-selective Beta adrenergic agonists…
Epi and Isoproterenol
Respiratory Anti-Inflamm. Steroids…
Pred. Prednisolone Fluticazone
The only direct acting parasympathomimetic…
Pilocarpine
Both parasympatholytic ophthalmic drugs are direct/indirect…
direct-acting
For fundic exams, choose…
Tropicamide
Sympathomimetic ophthalmic alpha-1 agonist…
Phenylephrine…indirect-acting; used in Horner’s diagnosis; cardio effects
Non-selective beta antagonist that treats and prevents glaucoma…decreasing aqueous humor production
timolol
carbonic anhydrase inhibitor…decreasing aqueous humor production
dorzolamide (be careful w/ sulfa allergies)
increases aqueous outflow…
latanoprost
cyclosporine is use in what species?
dogs only!
anti-inflammatory used to treat the back of the eye and immune-mediate keratitis/uveitis…
dexamethasone and prednisolone
topical NSAIDs that can be used for diabetic cataracts…
flurbiprofen and diclofenac
Levothyroxine reacts w/..
phenobarbital, zonisamide, sulfonamide, glucocorticoids, phenylbutazone, quinidine, etc.
You never give Ca Chloride…
SubQ or IM
It is best if you give Ca Gluconate…
IV…if you give it IV, dilute it!
When giving Ca Chloride/Gluconate, monitor w/….
EKG
Hypocalcemia due to HypoPTH give…
Ca Propionate and Ca Carbonate and may have to give calcitriol
What is the only oral hypoglycemic drug?
Glipizide
Endogenous glucocorticoid…
cortisol (made in zona fesiculata of adrenal gland)
Glucocorticoid protein transporter…
transcortin (preferentially bind to this instead of albumin)
Base steroid…
Prednisone
Salt esters…
make it more soluble….onset is faster, duration is the same
Insoluble esters…
onset slower and duration slower and cannot give it IV
Glucocorticoids (5)
Triamcinolone, Pred., Prednisolone, Dexamethasone, Methylprednisolone
A patient on glucocorticoid will have bloodworm w/…
decreased thyroid, stress leukogram
Where is aldosterone produced?
zona glomerulosa
Aldosterone….
Na-Retention! H2O-Retention!
First line of drugs for immunosuppression…
glucocorticoids
When do you use body-surface dosing?
Chemo and Levothyroxine
Metronomic…
lower doses for longer periods (more owner risk involved)