FINAL EXAM Review Vascular surgery ONLY Flashcards
PVD Preop Pharmacological mangement
- Beta-blockers
- Statins
Drug class that provides a cardioprotective effect in PVD:
Statins
PVD Preop Management
Metoprolol
- Tenfold decrease in cardiac mortality
- instituted days to weeks prior surgery
- Titrate dose to HR of 50-60 bpm
- Continue up to day of surgery and postop period
Cardioprotective effects provided by Statin drugs include:
- Decrease vascular inflammation
- Decrease incidence of thrombogenesis
- Enhance nitric oxide bioavialability
- Stabilize atherosclerosis plauques
- Decrease lipid concentration
Benefit of A-line in PVD Sx patients:
- Allows near-real time BP values
- Guides treatment options
Benefit of General Anesthesia in PVD sx patient:
Protects neurologic and cardiac tissue
Epidural anesthesia risk in PVD Sx patients:
High risk for epidural hematoma
Epidural CV benefits for vascular surgery:
- Increases hemodynamic stability
- Increases endocardial persuion at ischemic zone
Epidural Pulmonary benefits for vascular surgery:
Improves atrioventricular oxygen differentiation
PostOp PVD conditions include:
- Pain (SNS stimuation)
- Venous Thromboembolism (VTE)
- Deep Vein Thrombosis (DVT)
Inflammatory mediators increased in Acute Pain:
- Creatine kinase
- C-Reactive protein
- Interlukin (IL) 6
- Tumor necrosis factor (TNF)
Inflammatory Mediators lead to:
- Blood flow alteratios
- Organ dysfunction
- Cell death
VTE and DVT risk is increase during:
PostOp period
VTE and DVT prevention:
- LMWH (bridge)
- Restart oral anticoagulant postop when risk of bleeding is decrease
- Low HTC concentration
AAA mortality in men is:
2-3 times white > black
AAA surgery is recommended if:
AAA is > 5.5 cm or greater in diameter
Elective AAA surgery mortality
< 5%
5 year mortality of untreated AAA
81%
10 year mortality of untreated AAA
100%
Mortality rate of undetected AAA
35-94%
AAA risk factors
- Atherosclerosis (most common)
- Smoking
- Male
- White > Black
- Hypertension
- Advanced age
AAA physical examination will find:
Pulsatile abdominal mass
< 30 % of AAA are identified during:
Routine physical examination with PCP
Additional AAA risk factors:
- Presence of carotid artery disese
- PVD
- Obesity
- Diabetes
All these factors increase rate detection to 90%
AAA repair contraindications include:
- Intractable angina pectoris
- Recent MI
- Severe pulmonary obstruction
- Chronic renal insufficiency
Law of Palace
An Increase wall tension:
Increase vessel radius and intramural pressure
Ruptur risk for AAA 4-5 cm?
0.5-5 %/year
Rupture risk for AAA < 4cm
0%/year
Rupture risk for AAA 5-6 cm?
3-15%/year
Rupture risk for AAA 6-7 cm?
10-20%/year
Rupture risk for AAA 7-8 cm?
20-40%/year
Rupture risk for AAA > 8 cm?
30-50%/year
ECG lead to monitor during Aneurism rupture
- Lead II (dysrhythmias)
- Lead V (ST changes)
Most dramatic physicological change during Aneurysm rupture occurs:
During Aortic Cross-Clamping
Hypertension occurs
Proximal
Above clamping
Hypotension occurrs
Below clamping
Distal
Hormones increase during Aortic cross-clamping:
- Catecholamines
- Aldosterone
- Cortisol levels
Which patient are unable to compensate hemodynamic alterations duirng Aortic cross-clamping?
- Ischemic heart disease (IHD)
- Ventricular dysfunction
Tissue Ischemia during aortic cross clamping forms and release the following into circulation:
- Arachidonic acid
- nitric oxide
- Cytokine
- Prostaglandins
Anaerobic metabolism leads to the accumulation of:
Serum lactate
Mesenteric traction syndrome:
- Surgical maneuver to expose the aorta
- Decrease BP and SVR
- Tachycardia
- Increase CO
- Facial flushing
Suprarenal cross-clamp > 30 min leads to:
PostOp Renal failure
Clamp above renal arteries leads to:
Severe AKI
What decreases the incidence of AKI?
- Balanced crystalloid
- Hyperchloremic solutions
- Avoid Nephrotoxic drugs
- Avoid NSAIDs
- Avoid Aminoglycoside
Longitudinal blood supply:
- One anterior spinal artery 80%
- Two posterior & two post-lateral spinal arterial 20%
Transversed blood supply:
- Greater radicular artery (Adamkiewics)
- Originates between T8-T12
Spinal cord ischemia complications increase when:
Aortic cross-clamp is positioned higher
Spinal coard function is monitor with:
- SSEP
- MEP
Spinal caord protection strategies:
- CSF drainage
- Mild hypothermia
- Normotension SBP > 120 mmHg
- Distal aortic perfusion
Ischemic colon injury is attributed to:
Manipulation of the Inferior Messenteric Artery
Messentaric Artery supplies the:
Left colon
Non-Reflow Phenomenon occures when microvasculature is occlude by:
- Platelets
- Neutrophils
- Thrombi
Most blood loss aneurysm repair is due to:
Back bleeding from lumbar and inferior messenteric arteries
3 options for Autologous transfusion:
- Preoperative deposit
- Intraoperative phlebotomy and Hemodilution
- Intraoperative blood salvage
Autologous via cell saver system is:
Standard procedure