FINAL EXAM Review Vascular surgery ONLY Flashcards
PVD Preop Pharmacological mangement
- Beta-blockers
- Statins
Drug class that provides a cardioprotective effect in PVD:
Statins
PVD Preop Management
Metoprolol
- Tenfold decrease in cardiac mortality
- instituted days to weeks prior surgery
- Titrate dose to HR of 50-60 bpm
- Continue up to day of surgery and postop period
Cardioprotective effects provided by Statin drugs include:
- Decrease vascular inflammation
- Decrease incidence of thrombogenesis
- Enhance nitric oxide bioavialability
- Stabilize atherosclerosis plauques
- Decrease lipid concentration
Benefit of A-line in PVD Sx patients:
- Allows near-real time BP values
- Guides treatment options
Benefit of General Anesthesia in PVD sx patient:
Protects neurologic and cardiac tissue
Epidural anesthesia risk in PVD Sx patients:
High risk for epidural hematoma
Epidural CV benefits for vascular surgery:
- Increases hemodynamic stability
- Increases endocardial persuion at ischemic zone
Epidural Pulmonary benefits for vascular surgery:
Improves atrioventricular oxygen differentiation
PostOp PVD conditions include:
- Pain (SNS stimuation)
- Venous Thromboembolism (VTE)
- Deep Vein Thrombosis (DVT)
Inflammatory mediators increased in Acute Pain:
- Creatine kinase
- C-Reactive protein
- Interlukin (IL) 6
- Tumor necrosis factor (TNF)
Inflammatory Mediators lead to:
- Blood flow alteratios
- Organ dysfunction
- Cell death
VTE and DVT risk is increase during:
PostOp period
VTE and DVT prevention:
- LMWH (bridge)
- Restart oral anticoagulant postop when risk of bleeding is decrease
- Low HTC concentration
AAA mortality in men is:
2-3 times white > black
AAA surgery is recommended if:
AAA is > 5.5 cm or greater in diameter
Elective AAA surgery mortality
< 5%
5 year mortality of untreated AAA
81%
10 year mortality of untreated AAA
100%
Mortality rate of undetected AAA
35-94%
AAA risk factors
- Atherosclerosis (most common)
- Smoking
- Male
- White > Black
- Hypertension
- Advanced age
AAA physical examination will find:
Pulsatile abdominal mass
< 30 % of AAA are identified during:
Routine physical examination with PCP
Additional AAA risk factors:
- Presence of carotid artery disese
- PVD
- Obesity
- Diabetes
All these factors increase rate detection to 90%
AAA repair contraindications include:
- Intractable angina pectoris
- Recent MI
- Severe pulmonary obstruction
- Chronic renal insufficiency
Law of Palace
An Increase wall tension:
Increase vessel radius and intramural pressure
Ruptur risk for AAA 4-5 cm?
0.5-5 %/year
Rupture risk for AAA < 4cm
0%/year
Rupture risk for AAA 5-6 cm?
3-15%/year
Rupture risk for AAA 6-7 cm?
10-20%/year
Rupture risk for AAA 7-8 cm?
20-40%/year
Rupture risk for AAA > 8 cm?
30-50%/year
ECG lead to monitor during Aneurism rupture
- Lead II (dysrhythmias)
- Lead V (ST changes)
Most dramatic physicological change during Aneurysm rupture occurs:
During Aortic Cross-Clamping
Hypertension occurs
Proximal
Above clamping
Hypotension occurrs
Below clamping
Distal
Hormones increase during Aortic cross-clamping:
- Catecholamines
- Aldosterone
- Cortisol levels
Which patient are unable to compensate hemodynamic alterations duirng Aortic cross-clamping?
- Ischemic heart disease (IHD)
- Ventricular dysfunction
Tissue Ischemia during aortic cross clamping forms and release the following into circulation:
- Arachidonic acid
- nitric oxide
- Cytokine
- Prostaglandins
Anaerobic metabolism leads to the accumulation of:
Serum lactate
Mesenteric traction syndrome:
- Surgical maneuver to expose the aorta
- Decrease BP and SVR
- Tachycardia
- Increase CO
- Facial flushing
Suprarenal cross-clamp > 30 min leads to:
PostOp Renal failure
Clamp above renal arteries leads to:
Severe AKI
What decreases the incidence of AKI?
- Balanced crystalloid
- Hyperchloremic solutions
- Avoid Nephrotoxic drugs
- Avoid NSAIDs
- Avoid Aminoglycoside
Longitudinal blood supply:
- One anterior spinal artery 80%
- Two posterior & two post-lateral spinal arterial 20%
Transversed blood supply:
- Greater radicular artery (Adamkiewics)
- Originates between T8-T12
Spinal cord ischemia complications increase when:
Aortic cross-clamp is positioned higher
Spinal coard function is monitor with:
- SSEP
- MEP
Spinal caord protection strategies:
- CSF drainage
- Mild hypothermia
- Normotension SBP > 120 mmHg
- Distal aortic perfusion
Ischemic colon injury is attributed to:
Manipulation of the Inferior Messenteric Artery
Messentaric Artery supplies the:
Left colon
Non-Reflow Phenomenon occures when microvasculature is occlude by:
- Platelets
- Neutrophils
- Thrombi
Most blood loss aneurysm repair is due to:
Back bleeding from lumbar and inferior messenteric arteries
3 options for Autologous transfusion:
- Preoperative deposit
- Intraoperative phlebotomy and Hemodilution
- Intraoperative blood salvage
Autologous via cell saver system is:
Standard procedure
Opioids in vascular surgery provide
Cardiovascular stability
Epidural disadvantages
Epidural hematoma
Severe hypotension during blood loss
Aneurysm repair fluid management:
- Crystalloid at 10mL/kg/hr
- Initial blood ratio is 3:1
- Keep UOP at 1mL/kg/hr
Patienst with adequate LV functio, hemodynamic are preserve with a”slow” and “controlled” induction using:
- Higher doses of opioids
- sympathomimetics (if hypotension)
Identify Suprarenal and Juxtarenal AAA on the image
- A = Suprarenal
- B = Pararenal
- C = Juxtarenal
- D = Infrarenal
Which diuretic class decreases Renal ischemia and dysfunction?
- Osmotic Diuretics
- Loop Diuretics
Most common symptom of ruptered AAA?
Severe abdominal discomfort or back pain
If Hypocalcemia occur replacement is based on:
Calcium Ionized level
Treat with Calcium chloride
What helps maximize venous return and Keep O2 sat in AAA patients?
- Minimal PIP
- Higher FiO2 concentration
What improves alveolar recruitment and distention during AAA repair?
Manual positive pressure
Aortic dissection survival rate without surgery?
3 months
Aortic dissection is a tear within the
- Intima layer
- Allows blood flow
What layer is involved with a False Aneurysm?
Adventitia only
How many layers are involved in a True Aneurysm?
3 layers
Aortic dissection shapes:
- Fusiform (most common)
- Saccular
DeBakey AAA Classification
- Type I: Originates in the asceding aorta to aortic arch
- Type II: Originates in ascendig aorta. Confined
- Type III: Originates in descending oarta, extend distally
Standford AAA classifications:
- Type A: involve ascending aorta
- Type B: does not
Crawford Classification
Identify the Crawford Classification Type III and IV
- Type III = E
- Type IV = C
Thoracoabdominal Aortic Aneurysm
Thoracoabdominal Aortic Aneurysm Etiology:
- Atherosclerosis(most common)
- Marfan syndrome
Thoracoabdominal Aortic Aneurysm is most often classified as:
Fusiform
Hoarseness is due to:
Impingement on LRLN
Intrussion
Heparin dose required prior to aortic cross-clamping?
50-100 units/kg
Sytemic Heparinization dose on Vascular surgery
400 units/kg
Placement of Arterial line and pulse oxymeter during vascular surgery?
Right side
Due to intrussion of left subclavian artery
Thoracoabdominal Aortic Aneurysm patient position
Right lateral decubitus
Left-sided thoracotomy
Extend of thoracotomy is determined by:
Extent of aneurysm
Lower thoracic incision is associated with:
PostOp Pulmonary Dysfunction
Which aortic dissection type needs surgical intervention
Type A (higher incidence of rupture)
Which aortic dissection type is medically managed?
- Type B
- Arterial dilators and B-blockers
Anesthesia for ascending and transversed aortic dissection requires:
CPB
Descending Thoracic and Thoraco-Abdominal Aneurysm
When is surgery recommended for Patients with degenerative aortic disease
Size > 6cm
Connective tissue etiology for Thoracoabdominal AA:
- Elhers-Danlol syndrome
- Marfan syndrome
Infectious etiology for Thoracoabdominal AA:
- Spirochetal (Syphilis)
- TB
- Bacterial
- Fungal
Most common devastating consequence of Thoracic surgery
Praplegia
Which nerve is most succeptible to hoarseness?
LRLN
Due to proximity to aortic arch
The use of Intraop TEE is recommended for
Patients with myocardial dysfunction
Indwelling catheter assess:
Renal function
How is CSF pressure monitor?
Lumbar intrathecal catheter
Paraplegia incidence of 0-3% occur if surgery clamp is
< 10 min
Delayed paraplegia risk factors
- Type 2 aneurysm
- Renal failure
- Number of sacrified segments
Postop Risk factors for Delayed Paraplegia
- Hemodynamic instability by A-Fib
- Bleeding
- Multiorgan failure
- Spesis
Intervention to protect spinal cord during thoracic aortic cross-clamping:
- Routine CSF drainage pressure < 10 mmHg
- Moderate intraop hypothermia
- Avoid hypotension MAP > 90 mmHg
- Avoid SNP (steal phenomenon)
Breathing difficulties post extuabation are due to:
RLN dysfunction
EVAR is associated with:
30 day outcome vs OSR
Majority of Endoleaks are:
Type II (branch leaks)
It was a hotspot on selecting type II
In EVAR Endovascular graft migration can occur and lead to:
- Renal artery occlusion
- Postop Renal failure
Fenestrated EVSG is safe for patients with:
- Juxtarenal Aortic Aneurysm
- Suprarenal Aortic Aneurysm
Major EVAR advantages:
- Absence of aortic cross-clamping
- No incision from xyphoid process to the pubis
EVAR procedure use sytemic anticoagulation with
Heparin 50-100 units/kg
There is like 2 math questions on the exam
Second most common vascualar operation in the USA?
Carotid Endarterectomy (CEA)
Most CVA are due to
Ischemia > Hemorrhage
50% of strokes are preceed by a TIA
CEA benefits patients with:
- Recent ipslateral carotid territory symptoms
- Moderate to severe symptoms than asymptomatic patients
- Stenosis > 70%
CEA is less beneficail in patients with
50-69% stenosis
CEA surgical interventions are most beneficial in men:
- Older than 75 years
- Within two weeks of the event
Factors contributing to morbidity during CEA:
- Age
- Operative timing
- Hyperglycemia
- Mulitple comorbidities
- Contralateral carotid disease
- Progressing stroke
- Ulcerative lession
- Surgery with/whithout shunt
CEA variables affecting patient outcomes:
- State of collateral flow through circle of willis
- Presence of concurrent atherosclerotic disease
- Size and morphology of the offending plaque
- Specific symptoms
- Concurrent CV diseases
CEA common symptoms:
- Amaurosis fugax
- ALOC
- Aphasia
- Acute motor deficit
- Carotid bruit
CEA CV comorbidity risk include:
- DM
- PVD
- COPD
- Obesity
Normal cerebral flow
50 mL/100G/min
Cerebral cell death occurs at a flow of:
< 6 mL/100G/min
ALL anesthetic agents decrease metabolic rate, except:
KETAMINE!
Cerebral flow becomes pressure dependent due to:
Ischemia
Autoregulation and compensatory vasodilation
Cerebral monitoring standard tool include:
- EEG (Goldstandard)
- Carotid Stump pressure
Most sensitive and specific measure of CBF responsiviness in awake patient tool is:
EEG
Gross measure of pressure in the circle of willis:
Carotid stump pressure
A carotid stump pressure indicating neurologic hypoperfusion
- < 40-50 mmHg
- Criteria for shunt placement
Symptoms of inadequate cerebral perfusion include:
- Dizziness
- Contralateral cerebral perfusion
- LOC
CEA Blood pressure control
Maintain MAP at 20% or greater than preop MAP value
Drugs to decrease BP during CEA
- Nitroglycerine IV infusion
- Sodium Nitroprusside
Which nerve provokes hypotension and bradycardia during CEA
Carotid sinus Baroreceptor Nerve manipulation
Hypotension and Bradycardia Tx 2/2 Baroceptor stimulation:
- Stop surgical stimulation
- Infiltrate region with LA
- Give an antichollinergic
CEA Regional anesthesia Requires a deep and superficial pluxus block at:
CN II, III, and IV
GETA provides preconditioning in CEA by:
Decreases Cerebral and Metabolic Metabolism
CEA PostOp considerations
- BP 140/80 mmHg recommended
Chronic HTN leads to:
Cerebral hypoperfusion syndrome (CHPS)
Cerebral hypoperfusion syndrome (CHPS) symptoms:
- Headache
- Visual disturbances
- ALOC
- Seizures
What’s the initial manifestion of hemorrhage post CEA?
Airway obstruction
Emergency Tx for Hemorrhage post CEA include:
Hematoma evacuation
Recurrent Laryngeal Nerve damage leads to:
Inspiratory stridor
Identify vagal nerve on the image
Cranial nerve to assess for CEA:
- CN VII (facial)
- CN IX (glossopharyngeal)
- CN X (Vagus)
- CN XI (spinal accesory)
- CN XII (hypoglossal)
CEA Anesthesia considerations:
- ACT > 250 sec
- Atropine & Robinul prior inflation to offset vagal response
- Carotid duplex scan prior discharge
- ASA treatment for life