Final Exam Review

Question 1

TRKs recruit _ and activate _.

Answer 1

specific adaptor proteins

multiple intracellular pathways

Question 2

Peptidergic fibers are tagged with _

Answer 2

CGRP

Question 3

Non-peptidergic fibers are tagged with _

Answer 3

IB4

Question 4

NaV_ is TTX-resistant

Answer 4

1.8

Question 5

After PNI, NaV1.3 channel expression is _

Answer 5

increased

Question 6

After PNI, NaV1.8 _.

Answer 6

redistributes to the site of injury

Question 7

After PNI, TTX-resistant current at the site of injury is _.

Answer 7

increased

Question 8

NK1-positive dorsal horn neurons cause _ after injury

Answer 8

loss of mechanical and thermal hypersensitivity

Question 9

The PAG receives projections from _, _, and _.

Answer 9

Amygdala
NA
HyTh

Question 10

Antidepressant mechanism of action for pain

Answer 10

Increases NE levels in the dorsal SC

Question 11

Descending inhibition is thought to rely mostly on _

Answer 11

NE

Question 12

2nd order neurons cross the midline at _

Answer 12

the same level as their cell body

Question 13

peptidergic nociceptors used _, _, and _ as NTs.

Answer 13

Glu
Substance P
CGRP

Question 14

phenotypic changes in neurons after injury result in changes in _, _, and _.

Answer 14

ion channel expression
NT expression
Gene extression

Question 15

allodynia GABA hypothesis

Answer 15

increased NKCC1 activity causes GABA to evoke APs

Question 16

NKCC1 moves Cl _ cells which leads to _ efficiency of inhibition of the GABAergic system

Answer 16

into

less

Question 17

KCC2 moves Cl _ cells which leads to _ efficiency of inhibition of the GABAergic system

Answer 17

out of

more

Question 18

Opioids cause _ in dorsal horn neurons

Answer 18

LTP

Question 19

opioid LTP requires _

Answer 19

postsynaptic NMDARs

Question 20

COX1 is expressed in the _

Answer 20

gastric mucosa

Question 21

Chronic pain is defined as lasting _

Answer 21

3-6 months

Question 22

GABA/Gly are _ receptors

Answer 22

cis-loop

Question 23

Nerve injury downregulates V._

Answer 23

Kv9.1

Question 24

_ of the US population has chronic pain

Answer 24

1/3

Question 25

non-peptidergic fibers come from lamina _

Answer 25

II

Question 26

SC NE comes from the _

Answer 26

DLPT

Question 27

SC 5-HT comes from _

Answer 27

RVM

Question 28

_% of interneurons in the SC are projection neurons.

Answer 28

5

Question 29

_ and _ sections of the SC have large gray matter

Answer 29

lumbar

sacral

Question 30

A beta fibers come from lamina _

Answer 30

3, 4, 5

Question 31

The trigeminal nerve goes _ before synapsing in the brainstem

Answer 31

down

Question 32

PG-E2 acts on _ and _

Answer 32

cAMP and PKA

Question 33

Sensitizers act on _

Answer 33

metabotropic receptors

Question 34

Activators act on _

Answer 34

ion channels

Question 35

NE _ Alpha 2 receptors

Answer 35

activates

Question 36

NMDA and AMPA receptors are activated by _

Answer 36

glu

Question 37

TRPM8 is excited by _ and _

Answer 37

cold

mint

Question 38

TRPV1 is excited by _ and _

Answer 38

heat

capsaicin

Question 39

G(q) -> _ -> _ -> _ + _

Answer 39

PLC
PIP2
IP3 + DAG

Question 40

endorphins excite _

Answer 40

mu receptors

Question 41

Enkalphins excite _

Answer 41

delta receptors

Question 42

dynorphins excite _

Answer 42

kappa receptors

Question 43

The where pathway goes through the _ thalamus and ends in the _

Answer 43

ventral

sensory cortex

Question 44

The what pathway goes through the _ thalamus and ends in the _

Answer 44

dorsal

temporal cortex

Question 45

the _ bypasses the thalamus on the way to the cortex

Answer 45

parabrachial pathway

Question 46

The nociceptive amygdala is the _ amygdala

Answer 46

right