Final exam questions Flashcards
Describe the role of FSH and LH in male fertility
FSH and testosterone is required for spermatogenesis. LH is required for testosterone secretion
Describe the role of FSH and LH is female fertility
FSH is required to grow the follicle, LH is required for ovulation. estrogen is released from the ovary during follicular stage whereas LH is required for progesterone release from the corpus luteum
Describe the steps of PSA follow up based on the lab results
PSA <1 = 4 years repeat
PSA 1-3 = 2 years repeat
PSA >3 = More frequent testing
When do you stop PSA testing
6o yrs and a PSA of < 1
70yrs old
within 10 years of life expec
Define primary amenorrhea
no menarch by 16 years
no secondary sexual characteristics by 14 years
no menarch after 1 year of tanner stage 5
pneumoic for tanner stages in girls
No body elevates 2 mountains in adulthood
Breast: none, bud, elevated, 2 mounds, adult
Shes not a small cat
Pubic Hair: none, small, course and curley, adult, thighhs
What are the causes of gynecomastia
- Homrmone imbalance - resolution in 3 years
- If occurs before puberty refer to pediatrican
- Can be causes by anabolic steroids, kelienfelter syndrome, MJ
Differential for male infertility
Pre testicular:
Post testicular:
What is primary dysmenorrhea
Pain in the absence of pathology
What is secondary dysmenorrhea
Pain secondary to pathology such as endometriosis etc
Mifegymiso use
7-9 weeks - currently 63 days (looking to stretch to 70 days)
u/s for dates
Combination of mifepristone and misoprostol
Most common cause of urinary incontinence in men
BPH
Followed by neurogenic
Medication
Name 3 PDE5 medications and their dose and schedule
Sidinafil - 1hr before sex, 50-100mg lasts 4 hrs
Vardinafil same as sidniafil, 10-20mg, same as sidinafil
Tadinafil - long duration, take 60mins prior, 10-20mg. or daily 2.5-5mg
What medications can cause urinary concerns in men
Allergy, seditives, antichologenics, cardiology, psych meds
PDe5 ihhibitor side effects
Most common is headache. Contraindicates in nitrate use (must wait 24-48hrs), with unstable hypertension, cardiac, may cause hypertension with alpha antagonists (BPH)
Side effects, blue vision, hearing loss
Treatments for primary dysmenorrhea
NSAIDs - 2-3 days prior to onset of pain and first couple of days of menses
Combined OC or progesterone IUD
Symptoms for endometriosis
Deep pain, lower back pain, chronic pelvic pain
What investigations can be used for suspected endometriosis
Use U/S to rule out ovairian cysts and fibroids
GOld standard is laproscopty
Endometrial medical management
1st line is OCC or progestine (5-20mg OD 50% get break through bleeding or depo provera
2nd line is mirena
What investigations can be used for suspected endometriosis
Use U/S to rule out ovarian cysts and fibroids
GOld standard is laproscopty
Endometrial medical management
1st line is OCC or progestin (5-20mg OD 50% get break through bleeding or depo Provera
2nd line is mirena
Fibroid medical management
- IUD
- GnRh agonist - shrinks but will grow back within 12 months
- Selective progesterone eg ulipristal acetate
- Oral contraceptive
Differential for Female infertility
CUP - O
Cervical, strictures
Ovulatory - PCOS, POF, prolactinoma, thyroid, cusihings
peritoneal - endometriosis
Uterine/tubal - PID, adhesions, previous etcopic, fibroids
Differential for male infertility
Testicular - Varicoseal (most common), post infections lesions, post infection reduction infertility (mumps), Klienfelter, previous
What is Klinefelter syndrome
Primary hypogonadism, often associated with gynecomastia, being tall, more adipose, reduced fertility
what is the difference between primary and secondary hypogonadism
Primary = testicular failure (disease of the testies) Secondary = Disease of the hypothalamus or pituitary
what do the lab results for primary vs secondary look like
Primary = high FSH/LH & low testosterone and sperm count Secondary = Low/norm fsh/lh and low testosterone and sperm
Labs for fertility in women
Day 3 LH/FSH, prolactin, TSH, estrodiol, DHE
Day 21 progesterone
Definitions of menopause
Sterilisity if <50 and no period x 2 year or >50 and no period x 1 year.
Premature if < 40 yrs
Cessation of menstruation x 1 year
How soon before menopause does perimenopause start
About 4 years prior with irregular periods