Final Exam in Health Promotion Flashcards
At what age does the initiation of menstruation (menarche) start?
At ages 12 and 15
Menstrual cycles usually continue until age
45 to 55
What is the most frequent reasons why women visit the clinician?
Changes in menstruation
The normal menstrual cycle is how many days?
21 to 35 days with menstrual flow lasting 3 to 5 days, although a flow as few as 2 days or as many as 7 days is still considered normal
You want to reassure your patient that menstrual cycle that occur during first 1 to 1.5 years after menarche are frequently irregular , why?
due to immaturity of the hypothalamic-pituitary-ovarian axis
Fill the blank. Hypothalamus releases (what?) hormone that stimulates pituitary gland to produce
(which?) hormones?
Hypothalamus releases gonadotropin-releasing hormone (GnRH) and this hormone stimulates the pituitary gland to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH).
What are the two hormones secreted by ovaries?
Estrogen and progesterone at the command of FSH and LH
Which hormone targets the ovaries and results in production of estrogen and progesterone?
FSH
Which hormone targets developing follicle within ovary and responsible for ovulation, corpus luteum formation, and hormone production in the ovaries
LH
Which hormone is responsible for preparing the mammary gland for lactation?
Prolactin (PRL)
What are the three phases of ovarian cycle?
follicular phase
ovulation
luteal phase
What are the 3 phases in endometrial cycle?
proliferative phase
secretory phase
menstruation
What is the negative feedback effect in hormonal feedback system?
GnRH pulses stimulate the release of FSH and LH, as a result ovarian follicles develop and produce estrogen.
As the amount of estrogen in the circulation increases and reaches pituitary gland, it affects the amount of FSH and LH secreted—– this is called negative feedback
What is the positive feedback?
When the estrogen level becomes high enough, the negative feedback of pituitary is reversed and estrogen causes midcycle positive feedback effect on the pituitary which results in a surge of LH and FSH and causes ovulation
Which hormone influences the ruptured follicle to become corpus luteum?
LH-luteinizing hormone
Corpus luteum secretes which hormone?
Progesterone
Does progesterone reduce or increase the frequency of the hypothalamic GnRH pulses?
The presence of progesterone reduces the frequency of the hypothalamic GnRH pulses but the amount of LH released from pituitary is proportionally increased to sustain the corpus luteum and the production of progesterone.
What happens to corpus luteum and progesterone in the absence of pregnancy?
In the absence of pregnancy the corpus luteum degenerates, progesterone levels decline and menstruation occurs
What are the three phases that comprise ovarian cycle?
follicular phase
ovulatory phase
luteal phase
What is the primary role of FSH in follicular phase?
The primary role of FSH is to induce the development of increased receptors on the granulosa cells and thereby stimulate estrogen production
What is the preliminary role of LH in follicular phase?
To stimulate the cell’s production of androgen and that will be converted to estrogen by granulosa layers.
What is the name of the dominant follicle?
Graafian follicle
When does proliferative phase begin?
It begins about the fourth or fifth day of the cycle and usually last approximately 10 days ending with the release of the ovum
What are the three phases of endometrial cycle?
Proliferative, secretory and menstrual
When does secretory phase begin?
Secretory phase begins at ovulation, when it is part of a 28-day cycle it usually lasts from day 15 to day 28
When does menstrual phase begin?
The menstrual phase begins with initiation of menses and lasts 3 to 5 days
What are some health benefits of contraceptives?
Condoms reduce transmission of infectious disease
Risk for endometrial cancer is reduced with combined hormonal contraceptives ( CHC) and DMPA and non-medicated IUCs
Risk reduced for ovarian cancer even in women with BRCA1 and BRCA 2
helps and regulates withdrawal bleeding and dysmenorrhea
menstrual blood loss in menorrhagia reduced with use of CHC
Acne
Perimenopause- positive effect on bone mineral density ( role of estrogen in bone health)
You will educate your pt after femal sterilization to use another method for how long
for first 3 months
Next effective second from top method after sterilization
is depo shot , pill, patch, IUD, diaphragm
Do injections on time
Change diaphragm every time you have intercourse
Next level contraception third from top in the slide is
male condom, female condom used with spermicide, withdrawal method, sponge
Most common form of contraception reported by US females is
sterilization
Female sterilization health benefits
decreses risk of ovarian cancer
Female sterilization health benefits
decreses risk of ovarian cancer
With male-vasectomy, make sure you educate your pt
Make sure other methods of contraception used for first 3 months
What is the top tier of contraceptive
IUCs and implant (expalon?)
Copper T and ParaGard do not have hormone so they can be left for how long?
10 years
Levonogesterol can be inserted any time and health benefits are
Before IUD you want to make sure what tests done?
chlamydia and pap smear
IUD that has 52 mg of progesterone
reduces menorrhagia, heavy bleeding
Most side effect of LARC
Irregular bleeding/spotting
Copper IUC has what side effect?
has cramping
Copper IUC may be used as emergent contraception up to
7 days after intercourse and can be kept up to 10 days
WHO has list of medical problems that can exacerbate when using hormonal contraception, what is one of them?
migraines with aura is a contraceptive and pt can have ischemic stroke
Estrogen has been linked to with what condition
blood clots / stroke
if a woman more than 35 and migraine with aura you can offer what alternative
progestin-only, intrauterine and barrier methods
Patch is less effective in what kind of women
obese
What are independent risk factors for VTE
OBESITY
COC
age
What are the contraceptives for obese women over 35 ?
DMPA
progestin implant
IUC
vasectomy of partner
barrier methods
What is the oral EC for obese women?
ulipristal acetate
What are some medications that may reduce contraceptive efficacy via enzyme induction?
carbamazepine
felbamate
oxcarbazepine
phenobarbital
phenytoin
primidone
topiramate
What are other drugs that interfere with COC hormone levels
rifampin
In what medical condition would you use progestin only COC ?
Systemic lupus erythematosis
What are contraindications to contraceptives?
postpartum < 21 days ( breastfeeding and not breastfeeding
smoker > 35 years > 15 cigarettes a day (COC, patch, ring)
HTN > 160 SYS >100 and with vascular disease (COC,patch, ring)
Past hx of DVT PE DVT/PE and using anticoagulants, known thrombophilia
major surgery with prolonged immunization
previous or current ischemic heart diseae
migraine with aura
systemic lupus eryth
antiphospholipid SYNDROME
AB+
Other contraindications slide 27
distorted uterine cavity
unexplained vaginal bleeding
current breast cancer
active viral hep-s ( COC, patch, ring)
severe cirrhosis ( COC, patch, ring
hepatocellular adenoma
malignant tumor ( COC, patch, ring
cervical or endometrial cancer
postseptic abortion
puerperal sepsis
current PID
gonorrhea, chlamydia, purulent cervicitis
active gestationsl trophoblastic disease
pelvic tuberculosis
pregnancy
When you do first pap smear
Age 21
What is the cause for abnormal cervical cells?
HPV
Most common STI in U.S
HPV
Most commonly reported STI in U.S
Chlamydia
Treatment for genital herpes
1st infectionacyclovir 400 mg tid for 7-10 days
pt comes back month or two later– 400 mg TID for 5 days
pt comes back 3 months later—- acyclovir suppressive therapy 400 mg twice a day for a year
Trichomoniasis treatment
Flagyl 500 mg twice a day for 7 days