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Pharmacology I > Final Exam (Dermatologic Drugs) > Flashcards

Final Exam (Dermatologic Drugs) Flashcards

1
Q

CYP26A1

A

metabolizes retinoic acid

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2
Q

Photosensitizing drugs

A

thiazides, NSAIDs, tetracylcines, benzodiazepines, phenothiazines

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3
Q

Methoxsalen and PUVA (psoralen + UVA)

A

Tx of vitiligo (loss of melanin)

-take methoxsalen po (or topical, bath water) 75 min prior to PUVA light treatment

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4
Q

Photodynamic therapy (PDT)

A

photosensitizing drug + visible light

-porphyrin related compounds absorb visible light, transfer energy to O2, forms compound that kills cancer cells

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5
Q

Lindane

A
  • antimicrobial for Tx of body lice & scabies
  • lotion or shampoo
  • possible systemic neurotoxicity
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6
Q

Permethrin

A

-antimicrobial for Tx of body lice & scabies
-neurotoxicity is rare
cream rinse for lice = NIX

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7
Q

Prednisone

A

Tx for contact dermatitis

-nonfluorinated for face application

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8
Q

Retinoic acid

A
  • vitamin A analogue
  • agonist at nuclear receptors
  • regulation of epithelial differentiation
  • tetrogenicity
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9
Q

Tretinoin

A

RETIN-A - acne
RENOVA - photoaging
long Tx

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10
Q

Isotretinoin

A

ACCUTANE

  • 40% relapse
  • highly teratogenic
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11
Q

Methotrexate

A
  • Tx of immunologically mediated diseases

- results in bone marrow suppression

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12
Q

5-FU

A
  • Tx of immunologically mediated diseases

- treated areas inflamed, stops if DC

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13
Q

Cyclophosphamide

A
  • Tx of immunologically mediated diseases

- for most severe cases

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14
Q

Cyclosporine

A
  • Tx of immunologically mediated diseases

- HT & renal AE’s needs lab monitoring

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15
Q

Tacrolimus

A
  • Tx of immunologically mediated diseases

- requires sunscreen

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16
Q

Alefacept

A
  • Amevive
  • Biologic for Tx of psoriasis
  • requires weekly T cell count monitoring
17
Q

Efalizumab

A
  • Raptiva
  • Biologic for Tx of psoriasis
  • periodic evaluation of platelet count
18
Q

Etanercept

A
  • Enbrel
  • Biologic for Tx of psoriasis
  • TNF dimer
19
Q

Infliximab

A
  • Remicade
  • Biologic for Tx of psoriasis
  • MCA binds to TNF alpha
20
Q

Capsaicin

A

depletes substance P

Pharmacology I (10 decks)

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