Final Exam ANP1 Flashcards
FHypoglycemia can be defined as?
Blood glucose <60
What are 9 things that can cause hypoglycemia?
Can occur with diagnosis of diabetes (typically type 1)
medication use
illness
skipping or delaying meals
increase in physical activity
excessive alcohol consumption
decrease in carbohydrate intake
insulin overproduction
hormone deficiencies (in children, the growth hormone).
What is the criteria for level 1 hypoglycemia?
Glucose 54-70
What is the criteria for level 2 hypoglycemia?
Glucose <54
What is the criteria for level 3 hypoglycemia?
A severe event characterized by altered mental and/or physical status requiring assistance for treatment of hypoglycemia
What are 5 sign/symptoms of a severe/emergent hypoglycemic event?
Visual disturbances, blurred vision
Confusion
Loss of consciousness
Seizures
Death
What are 9 sign/symptoms of a mild/moderate hypoglycemic event?
Hunger
Shakiness
Irritability
Anxiety
Diaphoresis
Skin Pallor
Fatigue
Arrythmia
Crying out during sleep, Nightmares
What are the top 5 ethnicities that are at risk for diabetes in children and adults?
African American
Latino
Native American
Asian American
Pacific Islander
What BMI are Asian Americans considered obese therefore at higher risk for diabetes?
> 23
What 3 medical conditions put you at greater risk for developing diabetes?
CVD
PCOS (Polycystic Ovarian Syndrome)
HIV
What age group would you start screening for Diabetes?
Over 35
What lipid levels would you test for diabetes?
HDL <35
Triglycerides >250
In diabetic screening for adults would you screen if the patient has a 1st or 2nd degree relative with diabetes?
1st degree
An adult that is inactive should be screened for diabetes T or F?
True
The main criteria in screening for diabetes in children is?
Youth that are overweight or obese
What are 2 screening criteria for diagnosing diabetes in children related to family history?
Maternal history of GDM
1st or 2nd degree relative with diabetes
What are 4 medical conditions associated with a need for screening children for diabetes?
Acanthosis nigricans
HTN
PCOS
Small for gestational age birth weight
At what age or stage should you screen children for diabetes?
10 or onset of puberty, whichever comes first.
How often should you repeat screen for diabetes in children if their first screening is normal?
3-year intervals, more often if BMI increases
What are the HgbA1C values for non-diabetic, pre-diabetic, and diabetic?
non-diabetic <5.7
prediabetic 5.7-6.4
diabetic > or = to 6.5
What are the FBS values for non-diabetic, pre-diabetic, and diabetic?
non-diabetic <100
prediabetic 100-125
diabetic > or = 126
What are the 2 hour glucose tolerance test values for non-diabetic, pre-diabetic, and diabetic?
non-diabetic <140
prediabetic 140-199
diabetic > or = 200
What is the random blood sugar for diabetic?
> or = 200
To make a definitive diagnosis of diabetes you need to have?
2 positive tests or 1 positive lab and be symptomatic
Treatment of severe/emergent hypoglycemia includes?
IV D50 (Dextrose 50g)
IM or SQ Glucagon 0.5-1mg
Monitor LOC
Continuous infusion of glucose
Food if tolerated
Treatment of mild/moderate hypoglycemia includes?
Eat or drink 15 grams of glucose or carbohydrates (1/2 cup of soda, juice, 1 tablespoon of honey, sugar)
Recheck glucose level in 15 minutes, if still low then repeat 15 grams of glucose or carbohydrates
Repeat steps until glucose level returns to normal
Eat snack if next meal is more than an hour away
What is necessary to prevent recurrence of hypoglycemia?
To determine and treat the underlying etiology
How are most children diagnosed with diabetes?
The initial presentation of DKA
Define Diabetic Ketoacidosis
High levels of blood acids called ketones are produced.
What are 9 contributing factors in diabetic ketoacidosis?
Illnesses
surgeries
infections
medications
illicit drug use
pregnancy
bleeding disorders
ischemic incidents
What signs/symptoms in DKA are severe/emergent?
Deep, rapid breathing (Kussmaul respirations)
Tachycardia
Hypotension, orthostatic
Alteration of consciousness, decreased alertness
What signs/symptoms in DKA are considered moderate?
Fruity breath odor
Abdominal pain
Nausea and vomiting
Headache
Muscle stiffness or aches
Flushed face
What signs/symptoms in DKA are considered mild?
Frequent urination
Excessive thirst
Dry skin and mouth
Testing for Severe/emergent or moderate DKA includes?
Point of care blood glucose testing
Urinalysis
Electrocardiogram
CBC
CMP or electrolytes
Testing for mild DKA includes?
Point of care blood glucose testing
Urinalysis
Complete blood count
Compete metabolic panel
What is a characteristic that applies to type 1 diabetes (DM1)?
Significant hyperglycemia and ketoacidosis results from lack of insulin
Heredity and obesity are major risk factors for which type of DM?
DM2
You consider prescribing insulin glargine (Lantus) because of its:
extended duration of action
The onset of lispro (Humalog) occurs in
less than 30 mins.
You see an obese 25 year old male with acanthosis nigricans and consider ordering
ESR
Hemoglobin A1C best provides information on glucose control over the past:
64-90 days
In caring for a diabetic patient, how often should you obtain a urine microalbuminuria measurement?
Yearly
T or F In Alcoholic ketoacidosis significant hyperglycemia is present?
False
A patient with alcoholic ketoacidosis is at risk for developing?
Torsades de Pointes
Treatment for alcoholic ketoacidosis in Severe/moderate emergencies includes?
IV fluids, dextrose and saline solutions
Thiamine before dextrose in alcoholic patients
Potassium replacement
Phosphate replacement
Magnesium replacement
Name 17 symptoms that can be see with hypothyroid disease.
Fatigue
Increased sensitivity to cold
Constipation
Dry skin
Weight gain
Puffy face
Hoarseness
Muscle weakness
Elevated blood cholesterol level
Muscle aches, tenderness and stiffness
Pain, stiffness or swelling in your joints
Heavier than normal or irregular menstrual periods
Thinning hair
Slowed heart rate
Depression
Impaired memory
Enlarged thyroid gland (goiter)
Myxedema Coma symptoms include? (6)
Hypothermia
Variable blood pressure, hypotension when advanced
Bradycardia
Hypoventilation
Peripheral edema
Mental status change, coma
Low TSH High T4
Hyperthyroidism
High TSH low T4
Primary Hypothyroidism
Low TSH Low T4
Secondary Hypothyroidism
Thyroid (T4) replacement medications and usual dose range?
Synthroid (brand)
Levoxyl
Levothyroid
Unithiroid
generic levothyroxine for all
75-125mcg of levothyroxine
What disease is a common cause of hyperthyroidism?
Graves Disease
Excess circulating hormone from the thyroid gland resulting in hyperfunction is considered?
Primary Hyperthyroidism
Excess production of thyroid releasing or thyroid stimulating hormones in the hypothalamus and pituitary is considered?
Secondary Hyperthyroidism
Name 16 signs and symptoms of Hyperthyroidism.
Unintentional weight loss
Tachycardia
Arrhythmia
Palpitations
Increased appetite
Nervousness, irritability, anxiety
Tremors
Sweating
Changes in menstrual patterns
Increased sensitivity to heat
Changes in bowel habits, frequent bowel movements
Enlarged thyroid gland (goiter)
Fatigue, muscle weakness
Difficulty sleeping
Skin thinning
Fine, brittle hair
Name 18 signs and symptoms of Thyroid Storm.
Agitation
Change in alertness, consciousness
Seizure
Confusion
Diarrhea
Abdominal pain
Jaundice
Increased temperature
Tachycardia, palpitations
High systolic/low diastolic
Arrhythmia
Elderly:
Congestive heart failure
Atrial fibrillation
Restlessness
Shaking
Sweating
Weakness
Fatigue
Excess circulating thyroid hormone originating from any source is known as?
Thyrotoxicosis
A rare hypermetabolic state induced by excessive release of thyroid hormones that is acute, severe, and life threatening is known as?
Thyroid Storm
What is the most common precipitating cause of thyroid storm?
Infection
Treatment for Hyperthyroidism which is usually ordered by the Endocrinologist includes?
Anti-thyroid medication
Radioactive iodine
Beta blockers
Surgery, thyroidectomy
Hypothyroidism most often develops as a result of:
Autoimmune thyroiditis
Physical exam findings in patients with Graves’ disease include:
Eyelid Retraction
Thyroid stimulating hormone is released by the:
Anterior lobe of the pituitary
TSH of 24; free T4 of 3 is indicative of
Hypothyroid
TSH of <0.15; free T4 of 79 is indicative of
Hyperthyroid
Chronic, insufficient production of the hormones cortisol and aldosterone from the adrenal gland is known as?
Adrenal Insufficiency (Addison’s Disease)
Primary insufficiency is caused by?
Intrinsic adrenal gland dysfunction
Secondary insufficiency is caused by?
Inadequate adrenocorticotropic (ACTH) production due to hypothalamic-pituitary dysfunction.
What condition can be caused by a sudden withdrawal of oral steroids?
Adrenal Crisis
What is adrenal crisis?
An acute life threatening condition where there is a reduction of cortisol production.
What are 12 signs and symptoms of Adrenal insufficiency?
Extreme fatigue
Weight loss and decreased appetite
Darkening of the skin (hyperpigmentation)
Low blood pressure, even fainting
Salt craving
Low blood sugar (hypoglycemia)
Nausea, diarrhea or vomiting (gastrointestinal symptoms)
Abdominal pain
Muscle or joint pains
Irritability
Depression or other behavioral symptoms
Body hair loss or sexual dysfunction in women
What are 9 signs and symptoms of Adrenal Crisis?
Severe weakness
Confusion, delirium
Pain in lower back or legs
Severe abdominal pain, vomiting and diarrhea, leading to dehydration
Reduced consciousness or delirium
Low blood pressure
Circulatory collapse
Dehydration
High potassium (hyperkalemia) and low sodium (hyponatremia)
What is the treatment for Adrenal Insufficiency?
Hydrocortisone - Cortisol replacement
Which of the following is a mineralocorticoid?
A. Cortisol
B. Aldosterone
C. Insulin
D. Hydrocortisone
B. Aldosterone
A 40 year old man presents to the ED in acute adrenal crisis, and is experiencing nausea, vomiting, hypotension. Cyanotic and confused. Treatment is an injection of:
A. Epinephrine
B. Insulin
C. Adrenaline
D. Hydrocortisone
D. Hydrocortisone
Signs and symptoms of Hypercalcemia?
Increased thirst
Bone Pain
Muscle weakness
confusion
fatigue
upset stomach
nausea /vomiting
Constipation
A condition in which one or more of your parathyroid glands become overactive and release (secrete) too much parathyroid hormone (PTH) is known as?
Hyperparathyroidism
SIGECAPS Pneumonic
Sleep: insomnia or hypersomnia
Interest: reduced, with loss of pleasure
Guilt: often unrealistic
Energy: mental and physical fatigue
Concentration: distractibility, memory disturbance, indecisiveness
Appetite: decreased or increased
Psychomotor: retardation or agitation
Suicide: thoughts, plans, behavior’s.
What are the rules of 7’s in Major Depressive Disorder (MDD)?
1 in 7 persons with MDD commit suicide
70% of suicides have seen a PCP within 6 weeks
7th leading cause of death
Name 8 disorders that may cause depression.
CHF
Diabetes
Anemia,
Asthma
Hypothyroidism
Menopause
Chronic Diseases
Cancer
Name 6 drugs that may cause depression.
Antihypertensives
Corticosteroids
Hormones (progesterone and prednisone)
Antianxiety (Valium)
Birth Control Pills
GI (Reglan)
Criteria for diagnosis of major depressive disorders per DSM-V
Must have 5+ of following symptoms during two weeks (must include either depressed mood or anhedonia) in addition to:
Weight loss/gain
Increase/decrease in sleep
Increase/decrease psychomotor activity
Loss of energy
Feeling of guilt
Decreased ability to concentrate
Suicidal ideation/suicidality
DIGFAST pneumonic
Distractibility - poorly focused, multitasking
Insomnia - decreased need for sleep
Grandiosity - inflated self esteem
Flight of Ideas - complaints of racing thoughts
Activity - Increased goal directed activities
Speech - pressured or more talkative
Thoughtlessness - risk taking behaviors (sexual, financial, travel, driving)
What psychiatric medication can cause a rash that can lead to Stevens-Johnson Syndrome?
lamotrigine (Lamictal)
7 Common Disorders That May Cause Anxiety
Hyperthyroidism
Asthma
Alcoholism
Hypoglycemia
Delirium
Cardiac arrhythmia
MVP
5 Drugs That May Cause Anxiety
Amphetamines
Caffeine
Steroids
Appetite Suppressants
Drugs (street)
Criteria for diagnosis of schizophrenia per DSM-V
2+ symptoms must be present for one month and at least one must be 1., 2. or 3.:
1. Delusions
2. Hallucinations
3. Disorganized speech
4. Disorganized behavior
5. Negative symptoms
A screening tools that is used at every office visit for depression.
PHQ-9
A screening tools that is used for anxiety (General Anxiety Disorder), PTSD, Panic Disorder, Social Phobia.
GAD-7
A patient presents with symptoms ranging from Mild depression to Hypomania what type of bipolar is this?
Cyclothymia
A patient presents with symptoms ranging from major depression to Hypomania what type of bipolar is this?
Bipolar Type 2
A patient presents with symptoms ranging from Major depression to Mania what type of bipolar is this?
Bipolar Type 1
Name 5 SSRI’s used to treat depression.
Citalopram (Celexa)
Escitalopram (Lexapro)
Fluoxetine (Prozac)
Paroxetine (Paxil, Pexeva)
Sertraline (Zoloft)
What are some side effects associated with SSRI’S?
Nausea
Agitation
Sexual Dysfunction
Weight Gain
Insomnia
Hyponatremia
What SSRI is linked to the risk of dementia?
Paroxetine
What SSRI has a high risk of causing QTc prolongation?
Citalopram
What SSRI has an increased risk of problematic withdrawals and is harder to wean a person off of?
Paxil
Trazodone name 5 side effects.
Nausea (5-HT)
Priapism (α1)
orthostatic hypotension
headache
blurred vision
Circumscribed area of change in normal color, with no skin elevation or depression; may be any size is a?
Macule
Solid, raised lesion up to 0.5 cm in greatest diameter is a?
Papule
Similar to papule but located deeper in the dermis or subcutaneous tissue is a?
Nodule
What is the first line treatment for pyelonephritis?
Fluroquinolone to include
Ciprofloxacin 500 mg po BID X 7 days
Levofloxacin 750 daily x 7 days
2nd line is Bactrim DS 1 BID x 10-14 days