Final Exam Flashcards
What are the similarities in conservative mgmt of calcium oxalate and uric acid kidney stones?
Drink 14+ cups fluid/day
What are the differences in conservative mgmt of calcium oxalate and uric acid kidney stones?
Calcium oxalate
- low oxalate diet
- supplement
Uric acid kidney stones:
- low purine diet
- maint. alkaline uric >pH 6
What foods do you avoid if you’re trying to do a low oxalate diet for calcium oxalate stones?
Spinach Rhubarb Beet greens Nuts Chocolate Tea Bran Almonds Peanuts Strawberries
How much and what types of fluids should be emphasized and which should be avoided to reduce calcium oxalate stone risk?
14+ cups liquid / day
Most beverages even caffeinated, orange juice, lemonade
Citrates counteract dietary acids residues and inhibit crystallization
What type of fluid to avoid to reduce calcium oxalate stone risk?
Soft drinks (d/t sugar, phosphate) Grapefruit juice
What quantitative urine test can help guide doctor in managing kidney stones? Why?
24-hour urine analysis
Identifies patients with high output of CA, oxalate or uric acid
How can calcium supplementation be made safer for patients w/ history of kidney stones?
Calcium in food and with food reduces risk because calcium binds oxalate.
Citrate-containing calcium binds crystal, which inhibits the effect of citrate.
What is the role of Magnesium in the formation of kidney stones?
- quantity
- MOA and where does it act?
200-400 mg/day
Inhibits calcium crystallization in urinary tract
What is the role of Vitamin B6 in the formation of kidney stones?
- quantity
- MOA
50-150 mg/day
Aid oxalate catabolism
What is the role of vitamin C in the formation of kidney stones?
- quantity
- MOA
1000 mg/day
May have to be avoided if they increase urinary oxalate
For people with frequent urinary tract infections, what lifestyle modifications should be recommended?
High fluid intake
Frequent urination
Cotton underwear
What botanicals are suggested for urinary tract infections?
Cranberry
Vitamin A
Chinese herbal medicine
What is Caccinium macrocarpon?
Cranberry
What is the part of cranberry AKA Caccinium macrocarpon that is used?
Berry
Active part of cranberry AKA Caccinium macrocarpon?
Flavonoids
MOA of cranberry AKA Caccinium macrocarpon?
Inhibit adhesion of pathogens to epithelial cells
Dose of cranberry AKA Caccinium macrocarpon?
Juice 10-16 oz
Supplement 400-800 mg 2x/day
Safety concerns of cranberry AKA Caccinium macrocarpon?
GI upset
Weight gaine
Diabetics need more insulin
Who is cranberry AKA Caccinium macrocarpon contraindicated for?
Kidney stone risk
Anticoag therapy?
How much vitamin A should one take for urinary tract infections?
single dose 200,000 IU
What are the botanicals for benign prostatic hyperplasia? (5)
Saw palmetto (Serenoa repens, Serenoa serrulata, sabal serrulata)
Pygeum bark (Prunus africanus)
Nettle root (Urtica dioica)
ß-sitosterol
Pollen
What is Serenoa repens? Serenoa serrulata? Sabal serrulata?
Saw palmetto
What part of Saw palmetto (Serenoa repens, Serenoa serrulata, sabal serrulata) is used?
Berry
What is the MOA of Saw palmetto (Serenoa repens, Serenoa serrulata, sabal serrulata)?
Antiandorgenic
Antiproliferative
Anti-inflamm
What is the one small concern with Saw palmetto (Serenoa repens, Serenoa serrulata, sabal serrulata)?
That it may prolong bleeding in susceptible people
How do you take Saw palmetto (Serenoa repens, Serenoa serrulata, sabal serrulata)?
Lipophilic ripe berry extract 80-90% FA (320 mg/day in 1-2 doses)
Do not take it in tea bc water and FA do not mix
What is prunus africanus (African plum)?
Pygeum bark
What is the active part of Pygeum bark AKA prunus africanus?
Fat soluble sterols and triterpenes