Final Exam Flashcards
Stochastic effects
Cell DNA injury
No threshold
-All or non response
In stochastic effects the greater the does
Increases the probability of occurrence
Any amount of radiation
Deterministic effect
High amount of radiation
- Increased cell death
- Threshold does
Threshold dose
(Deterministic effect)
Clinical symptoms apparent at any dose above threshold
Severity is PROPORTIONAL to dose
2 types of effects from formation of free radicals
Direct effects
Indirect Effects
Law of Bergonie and Tribondeau
Radiosensitivity of different tissues
- Amount of undifferentiated cells
- Mitosis activity
- Length of active proliferation
Oocytes and lymphocytes
What cells have the highest radiosensitivity
Lymphoid tissues Bone marrow Testes Ovaries Small intestines
The more undifferentiated the more
Mitosis and more radiosensitive tissue that is
Oocytes and lymphocytes are highly _______ but very _____
Differentiated
Sensitive
Linear Energy Transfer
The rate at which energy from photons is imparted as they travel through matter
High LET
Densely ionizing
Low LET
Sparsely ionizing
As energy is given off
Different damage is done
Absorbed Dose
Measure of the total energy transferred from any type of radiation to matter
rad or Gy
100 rads =
1 Gy
Equivalent Dose
Measure of how different types of radiation affect various tissues
-Sv
Radiation sighting factor (Wr)
1 Sv=
1 Gy
Effective Dose
Measure of estimated risk in humans
-Sv
Tissue weighting factor (Wt)
Acute Radiation Syndrome
Whole Body irradiation
Onset is ore rapid and severity increases with greater dose
Management depends on stage
Mucositis
Second week of therapy
Erythematous mucosa Sloughing of the irradiated tissue Painful Secondary infection Difficulty consuming food Heals within 2 months after completion of radiotherapy
Xerostomia
Parenchuymal cells of salivary glands are radiosensitive
Reduced salivary flow
Pain/tenderness
Difficulty chewing and swallowing
May resolve in 6-12 months
Taste Loss
Second/third week of therapy
Reduced salivary flow my a contributing factor
Reversible
Trips us
Inflammation and fibrosis of musculature
Limited opening 2 months after completion of radiation therapy
PT
MOM affected
Radiation Caries
Rampant tooth decay
-mostly due to salivary gland changes
Maintenance and compliance
-daily fluoride varnish
Impeded Tooth Development
Children receiving radiotherapy -Incompletely formed teeth —root development -Malformed teeth -Tooth bud destruction -Microdontia
Restorative procedures
Osteoradionecrosis
50-60 Gy
Reduction of blood supply bone remolding capacity and mineralization
breakdown of oral mucosa
Mandible>maxilla
Debridemtn
Resection
Restorative procedures
Pre-Radiotherapy clearance when possible
Is radiation induced cancer a stochastic effect of radiation?
True; even one does of radiation can cause cancer. More doses increase risk but the end result does not change
All electromagnetic radiation can cause carcinogneis
False
The closer to the nucleus the higher the
Bonding energy
Highest bonding energy shell
K
Lowest bonding energy shell layer
P
Z number
(Atomic number)
of protons
Same number of electrons in a neutral atom
A number (Atomic mass #)
of P+N
The binding energy of electrons in a specific end shell is higher in an element with
A high Z number
T/F Radaiton induced cancer is a stochastic effect of radiation
True
No threshold increase amount increases risk
T/F All electromagnetic radiation can cause carcinogenesis
False
Not all is the same
Which electrons have highest bonding energy
Closer to nucleus
Which shell is closet to nucleus
K shell
Klmnopq
Z number
The number of neutrons protons in a neutral atom
Higher atomic number (z number)
Higher the bonding energy
Z number is the same as # of
Electrons in a neutral atom
A number:
of Protons + neutrons
Radiation is energy in
Motion
Radiation moves
In a straight line from a central point
It diverges
If the radiation beam is further away
More face face would be exposed because it is divergent
Radiation can be ___ or ___
Electromagnetic (waves) or particulate (particles )
Radiation can be _____ or ____ radiation
Ionizing
Nonionizing
Ionization
Reaction that has sufficient energy to remove electrons from atoms it encounters in its path
Wave theory
Radiation is propagated as waves
Electric and magnetic fields are in planes at right angles
Travel at speed low light
How far from source do you have to be away
6 feet
_____ wavelength has higher energy
Shorter
Frequency and wavelength are _____related
Inversely
Wavelengths
Distance between 2 succcesive crests or troughs
Measured in meters or angstroms (X-rays)
Frequency
of oscillations vibrations or cycles per second
Electromagnetic radiation
Transfers of energy through space as a combination of electrical and magnetic fields
Quantum theory
Electromagnetic radiation is considered as bundles of energy called photons
Higher frequency _______ energy
Higher
Longer wavelength
Lower energy
Lower frequency
Ionization
Gaining or losing an electron
y
Ionization occurs when
Occurs when particulate or electromagnetic radiation energy is greater than binding energ
Threshold for ionization
10e
Types of ionizing good radiation
Gamma rays x rays and some UV rays
In ionization the ejected particle
Is a negative ion
The remainder of atom is positive
X rays are produced when
velocity electrons are suddenly declarations when they pass close to the nuclei of high Z# absorbing material
3 requirements for X-ray production
Electrons
High velocity of electrons
High Z number absorbing material (tungsten )
2 mechanism of X ray production
Electron to nucleus
Electron to electron interaction
Electron to nucleus interaction
Bermesstrahlung radiation
-the fast voting electrons either slow down or stop when they come close to the nucleus of the atoms and part of their energy is transferred as X rays
Electron to Electron interaction
Characteristic radiation
Few electrons interact with tungsten target originated electrons imparting enough energy to ionize the tungsten target
When electrons displace inner shell electrons, characteristic radiation is produced
Electrons have different kinetic energies
True
Homogenous radiation
AC converted to DC
All cathode electrons will have similar KE and the resulting radiation is more homogenous
Which is less radiation to patient homogenous or heterogenous radiation
Homogenous
Long wavelength radiation have more energy compared to short wavelength T/F
False
Which shell of an atom has the greatest binding energy
K shell