Final Exam

Question 1

Two toxins produced by the lupine plant?

Answer 1

Quinolizidine alkaloids, piperidine derivative alkaloids

Question 2

Target organs/species and mechanism of lupine plant poisoning?

Answer 2

CNS/fetus - acetylcholine agonist

Sheep > horses/cattle

Question 3

Key clinical features of lupine poisoning?

Answer 3

Cholinergic toxidrome
Teratogenic - inhibits fetal movement resulting in arthrogryposis

Question 4

Management of lupine poisoning?

Answer 4

Antidote - atropine
Prognosis varies by severity of intoxication, but full recovery is possible

Question 5

Target organs/species and mechanism of death camas poisoning?

Answer 5

CNS/heart - altered membrane potential causes prolonged opening
Sheep/goats > cattle > others

Question 6

Key clinical features of death camas poisoning?

Answer 6

GI upset
Bradycardia and hypotension
Tremors and severe depression/weakness
Progression to tachycardia, respiratory distress, cyanosis, coma, death

Question 7

Postmortem lesions associated with death camas poisoning?

Answer 7

Severe pulmonary congestion and edema, thoracic SC hemorrhage