Final Exam Flashcards
What is public health?
the science and art of promoting health, preventing disease, prolonging life, and improving quality of life through the organized efforts of society
-based on principles of primary health care
What is the Public Health Agency of Canada?
an agency whose role is to promote and protect that health of Canadians through research, innovation and collaboration
Define prevalence
refers to the total number of people in a population (including new and existing) affected by a particular health condition (disease/injury) at a particular time
What increases prevalence?
-decreased mortality
-improved life expectancy
-increasing incidence of disease
What decreases prevalence?
-recovery (cure)
-death
What causes the incidence rate to increase?
-rise in development of disease (epidemics)
-sudden, improved disease-reporting procedures
What causes the rate of incidence to decrease?
-resolution of epidemics
-cure
-excellent prevention measures
What is age-adjusted rates?
-adjustment of rates so that meaningful comparisons of rates for important health outcomes between different geographic regions can be done and allows comparisons over time to be made by accounting for an aging population
What is the web of causation?
an illustration of the complex interrelationships of numerous factors sometimes interacting in subtle ways to increase (or decrease) the risk of disease
What are Bradford Hill’s criteria for causation?
9 criteria for causation
-strength of association
-consistency
-specificity
-temporal relationships
-plausibility
-biological gradient (dose-response)
-coherence
-experimental evidence
-analogy
Describe Strength of Association
-a Bradford Hill’s criteria
-says that a strong association provides firmer evidence of causality than do weak ones
-quantified by a measure (ex. ratio)
-the reverse, however, is not true
Describe the Bradford Hill criterion Consistency
-similar findings found in multiple studies through diverse methods, in different populations, and under a variety of circumstances shows strong association
-consistency along, however, does not prove causation
Describe the Bradford Hill criterion Temporality
-exposure to the causal factor must PRECEDE the onset of disease
-this criterion is REQUIRED to establish causation
retrospective studies and cross-sectional studies will also NOT be able to show temporality
Describe the Bradford Hill criterion Biological Gradient
-an increase in the level, intensity, duration or total level of exposure to an agent leads to progressive increase in risk
-ex. smoking and lung cancer
-if a threshold exists below which no further harm is done, further reduction in exposure is unwarranted
What is analytic epidemiology?
-testing the hypothesis
-addressing the question “why?”
-seeks to explain already observed patterns
-usually more rigorous study design, so more expensive
-“why are certain groups at high or lower risk of disease X than others?”
What are the types of experimental analytic studies?
-randomized control trials
-non-randomized studies
What are the types of observational analytic studies?
-cross-sectional
-longitudinal (cohort and case-control)
Describe randomized control trials
-most rigorous of the studies
-random allocation of population into 2 groups (experimental or control)
-blinding (double blind? placebo?)
-results observed at some future time (always prospective)
-ethical/logistical problems
-directionality always Exposure -> Outcome
Describe cross-sectional studies
-information about outcome and exposure in a defined population is collected at one point in time
-attempt to address question of strength of association between exposure and outcome
-difficult to establish temporality (did E occur before D?) therefore cannot establish causation
-multiple sampling strategies (random, systemic, stratified, cluster)
-measure– point prevalence
Describe a Cohort study
-tracks groups of individuals over time
-selection based on exposure
-forward directionality (E–>D) prospective
-study one exposure, many outcomes
-not suitable for studying rare disease
-measure: relative risk (RR)
Describe Case-control studies
-selection based on outcome/disease
-backward directionality (E<–D) retrospective
-study one disease, many exposures
-persons with rare disease of interest are compared to another group without the disease
-purpose: do 2 groups differ in proportion of exposure to specific risk factors?
-measure: Odds Ration (OR)
Describe the risk ratio
-the ratio of the incidence of a health outcome (disease) among the exposed to that among the unexposed
Define reliability
the precision of a measuring instrument, which depends on its consistency from one time of use to another, and its repeatability
What is positive predictive value vs negative predictive value?
-ability of test to predict the presence or absence of disease
Positive Predictive Value: the proportion of persons with a positive result who actually have the disease
Negative Predictive Value: the proportion of persons with a negative result who are actually disease free