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531 Med Chem > Final Exam > Flashcards

Final Exam Flashcards

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1
Q

CYP1A1

A

Oxidizes planar polycyclic aromatic compounds

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2
Q

1A2

A

-aromatic nitrogens
-caffiene, impipramine, acetaminophen

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3
Q

CYP2C9/CYP2C19

A

-wide variety of drugs
-warfarin
-ibuprophen
-phenytoin
-omeprazole

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4
Q

2D6

A

-wide variety
-antidepressants and antispycotics

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5
Q

2E1

A

-small molecules
-ethanol
-acetaminophen
-general anestetics
-halogenated hydrocabons

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6
Q

CYP3A4/3A5

A

-most abundant
-metabolizes most drugs

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7
Q

CYP1A1/1A2: inducers

A

-dioxin
-smoking

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8
Q

2D6: inhibitor

A

paroxetine

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9
Q

2E1 inducer

A

ethanol

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10
Q

3A4 inducers

A

-carbamzepine
-St Johns wort

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11
Q

3A4 inhibitors

A

-erythromycin
-grapefruit juice

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12
Q

True or false: all CYP rections are Phase 2

A

phase 1

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13
Q
A
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531 Med Chem (2 decks)

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