FINAL EXAM Flashcards
Non-invasive brain stimulation technique to modulate cortical
excitability, enhance motor learning, and improve motor function.
TDCS (Transcranial Direct Current Stimulation)
TDCS includes direct current to the scalp for 3 to 20 minutes through surface electrodes (anode and cathode) with the goal of increasing (________ stimulation) or decreasing (_________stimulation) cortical excitability.
anodal; cathodal
The increases in cortical excitability are thought to be the underlying factor leading to gains in performance.
The increased cortical excitability elicited by (tDCS) RESEMBLES the cortical excitability often OBSERVED following PRACTICE of a motor task, which has been interpreted as use-dependent plasticity in the primary motor cortex.
The most commonly studied and effective electrode montage involves……..
placing the anode over the primary motor cortex (M1) and the cathode over the opposite eyebrow (supraorbital region; SO).
This electrode arrangement usually elicits increases in M1 excitability on the order of 20-30% and increases in motor performance of about 10% with ONE 10–30-minute tDCS application.
M1-SO montage
Time course for tDCS Effects:
13 mins anodal tDCS at 1mA increased cortical excitability for 9 minutes
Rationale for use and tDCS Effects:
Short-term effects due to alterations in membrane potential. Increased motor cortex excitability underlies performance enhancement.
Long-term effects due to changes in synaptic strengthening, protein synthesis, receptor function, and other mechanisms.
Improvements in motor function are usually about 10% for a single session in
young and old adults.
Remember this occurs more efficiently in SIMPLE TASKS
More impaired people/populations (stroke, Parkinsons Disease) usually benefit more.
TDCS effectiveness
Current tDCS research limitations
Most of the optimal acute stimulation parameters are unknown in all populations and long-term studies in most of them are lacking.
Why study NIBS in motor disorders?
in the last decade, a number of studies have shown that NIBS (non-invasive brain stimulation) can modulate cortical excitability and improve motor function in a variety of groups such as healthy subjects, older adults, stroke, Parkinson’s disease (PD), and several others.
the system of memory that is perhaps the most familiar.
Is the memory system that has a conscious component, and it includes the memories of FACTS and EVENTS.
A fact like “Paris is the capitol of France”, or an event like a prior vacation to Paris
The declarative memory system (Explicit):
includes the type of memory systems that don’t have a conscious component, but nevertheless are extremely important. They include memories for SKILLS and HABITS (riding a bike, driving a car, playing tennis, golf or the piano.
a phenomenon called priming, simple forms of associative learning (classical conditioning/Pavlov), and finally simple forms of nonassociative learning such as habituation and sensitization.
Non declarative memory/implicit memory:
Differentiate between declarative and non declarative
Declarative memory is knowing what; nondeclarative memory is knowing how.
Classical Conditioning in a Pavlovian Conditioning Task
Rabbits and cat experiments have shown that they can maintain this behavior after removal of hippocampus, thalamus, or cortex
However, this learning doesn’t occur of there are lesions or removal of the lateral cerebellum, dentate, or interpositus
H.M. study (anterograde amnesia)
After the operation H.M.’s ability to form any new memories for facts and events was severely impaired; he had great difficulty learning any new vocabulary words; he could not remember what happened the day before.
While he could form new memories for skills and habits, he did not know that he had the skills! He had no awareness of the memory; he couldn’t declare that he had it.
Anterorgade amnesia
inability to form new memories.
HM study clearly indicated that the hippocampus was critical for memory formation (anterograde amnesia).
Retrograde amnesia
refers to loss of old memories.
consolidation
The process by which an initially labile memory is transformed into a more enduring form
Know functions of brain structures:
The Basal ganglia is where you store new skills and habits. Amygdala is important for emotional responses. Skeletal musculature occurs in the cerebellum.
Mechanisms of memory
Learning involves changes in the strength of synaptic connections between neurons. What has changed is that the strength of a previously existing connection is modified.
like the memory for a telephone number that last several minutes.
Short-term memories
the memories that last days, weeks or a lifetime.
Long-term memories
major differences between long and short term memory are…..
Long-term memories involve changes in protein synthesis and gene regulation, whereas short- term memories do not.
the biological process by which synaptic transmission is transiently enhanced, usually because of an increase in synaptic vesicle release probability
Short term potentiation (STP)
believed to be involved in many examples of declarative memory. It is present in the hippocampus, which is known to be involved in declarative memories.
Long term potentiation (LTP)
Know that changes in gene progression do not occur all at once
there are different phases
Fitts and Posner 3 stage model:
Cognitive stage (working memory): beginner focuses on solving cognitively oriented problems related to what to do and how to do it.
Associative stage (procedural processes): person has learned to associate environmental info w/require movements to achieve the goal of the skill.
Aka refining stage: person focuses on performing the skill successfully and being more consistent from one attempt to the next
Autonomous stage: final stage where performance of the skill is “automatic” or habitual
Gentile two-stage model:
unique features of Gentile’s “later stages”
Closed skills (predictable and static environment). Require fixation of movement coordination patterns
Ex: free throw line
Open skills (dynamic and changing environment): require diversification of the basic movement pattern.
Importance of Performer and Performance Characteristics at each learning stage
Benefits of considering these characteristics are: they explain why different strategies are needed for people in different learning stages