Final Exam Flashcards
Graves’ disease
Autoimmune disorder involving the formation of auto antibodies that mimic TSH. The antibodies bind to TSH receptors on the follicular cells of the thyroid, causing an abnormally high level of TH release. Same symptoms as hyperthyroidism(>metabolism,weight loss, hyperactivity, heat intolerance) plus bulging eyes known as exophthalmos. Treated by removing thyroid or radioactive iodine injections
Cushing syndrome
Abnormal pattern of adrenal cortical function
Results from the chronic exposure of the bodies tissue to excessive levels of glucocoticoid hormones. This complex of symptoms is seen most frequently in people taking corticosteroids as therapy for autoimmune disorders such as rheumatoid arthritis, although some cases result when the adrenal gland produces too much of its own glycocorticoid hormones
Characterized by obesity(face, moon face) buffalo hump, hypertension, hirsuitism(male pattern hair growth) kidney stones, menstrual irregularities
DM1
Insulin dependent “juvenile diabetes”
Absent or diminished production and release of insulin by the beta cells of the pancreatic islets
Not directly associated with obesity
Genetic predisposition +trigger(viral infection)
Treated with insulin injections(stem cells)
Functions of blood
Gas exchange(o2,co2),
transport
nutrients and priducts of metabolism
Enzymes
Hormones
Buffers to regulate pH
Regulate temp
Regulate fluid balance
Protect against infection(luekocytes, plasma protiens)
Protect against blood loss(clotting via platelets,plasma protuens)
Review fig 18.12
3 phases of hemostasis(stop the bleed)
Hemostasis: stoppage of bleeding, 3 phases, vascular spasm, platelet plug, coagulation
Fig 19.22 heart anatomy &ecg
Table 20.2 types of capilaries
Continuous, fenestrated, sinusoidal
Pic on phone
Compare/contrast anatomy of blood and lymphatic capillaries
Sim: wall composed of endothelium
Diff:
LC larger in diameter, no basement membrane, overlapping endothelial cells act as one way flaps to allow fluid in but not out
LC are close ended, BC form a loop
Function of thymus
Primary lymphoid structure
Belobed, superior mediastinum
Functions in t-lymphocyte maturation, secrete thymulin
When idms thymus at maximum size
Puberty(30-50g)
Description of continuous capillaries
Complete endothelial lining around lumen
Complete basement membrane
Entercellular clefts between endothelial cells
What materials pass through continuous capilaries
Plasma and it’s contents(-most proteins)
Some leukocytes
Locations of continuous capillaries
Most capillaries
Muscle, thymus,brain,spine,skin,lungs
Description of fenestrated capillaries
Same as continuous +fenestrations
What passes through fenestrated capillaries
Large amounts of materials are filtered,released, or absorbed
Some smaller proteins
Locations of fenestrated capillaries
Small intestine(absorp nutrients)
Ciliary process to produce aqueous humor in eyes
Description of sinusoidal capillary
Incomplete lining of endothelial cells around lumen
Incomplete or absent basement membrane
What passes through sinusoidal capillaries
Large substances(formed elements, large plasma proteins)
Plasma
Locations of sinusoidal capillaries
Red bone marrow for formed elements to enter blood
Liver for monitoring blood contents(for potentially harmful substances)
Where does activation of lymphocytes occur
Secondary lymphoid structures usually lymph nodes or spleen
Activation of lymphocytes occurs in
Secondary lymphoid structures, usually lymph nodes or spleen
Lymphocytes activation results in
Proliferation and differentiation to form a clone of identical cells that includes memory cells
Antigen challenge
First encounter between antigen and lymphocyte
What do b lymphocytes mostly become on activation
Differentiate into plasma cells that produce antibodies
Structural organization of respiratory tract includes
Upper:nose, nasal cavity, pharynx,larynx
Lower:trachea, lungs, bronchus, bronchiole, terminal bronchiole
Functional organization of respiratory tract
Conducting zone:nose, nasal cavity, pharyngitis, larynx,trachea, lungs, bronchus, bronchiole, terminal bronchiole
Respiratory zone: respiratory bronchiole, alveolar duct, alveoli
Conducting zone
Passageways that transport or conduct air
Think train track for air
Respiratory zone
Structures that participate in gas exchange with blood
Hormones that increase Na+ reabsorption
Aldasterone, cortisol, estrogen,GH, TH, insulin
Hormones that decrease Na+ reabsorption
Atrial natriuretic peptide, progesterone, PTH, glucagon
Obligatory water reabsorption occurs where
Proximal convoluted tubule, ~65%
How much water is reabsorbed in the nephron loop
~10%
What/where regulates the amount of water excreted in urine
Collecting tubules and collecting ducts in response to ADH binding
How does ADH Regulate the amount of water excreted in urine
ADH causes an increase in aquaporins resulting in an increase in water reabsorption
Fig 24.20
What hormone regulates the reabsorption of calcium and phosphate ions
PTH inhibits reabsorption of PO⁴³‐, and stimulates Ca²+ reabsorption
Fig 24.22
What are the two major fluid compartments in the body
Intracellular and extracellular fluid comoartments
What is intracellular fluid
Fluid within cells
How much body fluid is intracellular
⅔
What is extracellular fluid
Fluid outside of cells