Final Continued

Question 1

Give examples of small intracellular signaling molecules

Answer 1

Cyclic AMP

Inositol triphosphate and diacylglycerol

Question 2

What is the purpose of cyclic AMP

Answer 2

Activates the enzyme cyclic AMP dependent protein kinase (PKA) which can phosphorylate serines or threonines

Question 3

What generates IP3 and DAG

Answer 3

Phospholipase C

Question 4

What happens when PI 3 and DAG is activated

Answer 4

IP3 releases calcium from the er to the cytosol. Then DAG activates PKC with the calcium. PKC then phosphorylate other intracellular protein in order to propagate the signal further

Question 5

What happens when RAS is active

Answer 5

Activates the MAP kinase signaling module

Question 6

What happens when RTKs activate activate PI 3 kinase

Answer 6

Serve as a docking site that can active other intracellular signaling proteins

Question 7

What is the relationship between delta and botch

Answer 7

Delta binds to its receptor called notch. Notch is cleaved and migrated to the nucleus to promote transcription of proteins.

Question 8

What are RTKS

Answer 8

receptors that form dimers with each other when activated