Final: Addictive Disorders Flashcards

1
Q

Clinical steps re addition tx

A
  1. assess, dx
  2. Referral (inpt v outpt)
  3. Detox protocols
  4. Rehab involvement (inpatient)
  5. Intensive Outpt (ie 3x/wk for 3 hr for 3m)
  6. Long term f/u (outpt)
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2
Q

describe the bio-psycho social model

A

Bio: genetic predisposition, cellular changes

Psycho: Cognitive Behavior

Social: environment, inner circle

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3
Q

Describe the systems of the brain

A

*Prefrontal cortex: judgment and willpower, EXECUTIVE CONTROL

Limbic system: basic emotions and learning

Amygdala: alerts brain to temptation

Substantia nigra: DA, (mvmt)

Locus Ceruleus

*Ventral tegmental area: REINFORCEMENT

– as a neutral disorder, the balance bw drive and control systems

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4
Q

describe the interactions bw the systems

A

Locus ceruleus to VTA (reinforcement) to nucleus accumbens to activate (+) prefrontal cortex (executive control)

Prefrontal cortex inhibits (-) Nucleus accumbens and VTA (reinforcement)

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5
Q

What underlies genetic predispositions for addiction

A

inherited abnormalities in DA system

DA transporter.. any compulsive disorder, there is some dysregulation of this receptor

cocaine blocks reuptake of DA

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6
Q

As a kid, exposure to chronic stress around age 4-6….

A

results in cortisol secretion that can prime brain pleasure pathway for addiction

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7
Q

Compulsive disorder cycle

A

anxiety/stress causes repetitive behaviors which serve as relief of anxiety/stress -> obsessions –> back to anxiety and stress

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8
Q

Levels of drug use include? where is America?

A
  1. Abstinence
  2. experimentation
  3. Social/recreational use**
  4. Habituation
  5. Abuse
  6. Addiction

most of Americans are social/rec use

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9
Q

3 step clinical process for recovery…

A
  1. Screen our job in Primary care: CAGE or AUDIT screen questions
  2. Dx: Psychiatry/addiction med via MAST, DSM etc
  3. Treat: inpt detox/rehab and/or outpatient rehab/follow up
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10
Q

how can we screen for addiction?

A

best to do so in context of other lifestyle questions in primary care setting

  1. CAGE
    a) 2+ as cut off, quick and easy
  2. AUDIT - 10 questions
    a) best for ETOH abuse, problem drinking
  3. MAST
    a) best for alcohol dependence

– if positive screen, assess for referral & dx

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11
Q

What is the breakdown for DSMIV organization of addiction dx

know** for exam

A

CLASS: substance related disorders

GROUP: Substance USE disorders v Substance INDUCED disorders

DISORDER:

a) *under substance use: ABUSE vs DEPENDENCE
b) under substance induced: intoxication, withdrawal, delirium, dementia, amnesia, psychosis etc

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12
Q

DSM-IV criteria: use disorders - substance abuse

A

1 or more within 1 yr:

a) failure to fulfill work, school, or home obligations
b) physically hazardous situations
c) Legal problems
d) Recurrent social or interpersonal problems

[[failed obligations, physical health risk, legal trouble, relationships]]

obligations, health, law, relationship (one OHLR)

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13
Q

DSMIV criteria: use disorders: SUBSTANCE DEPENDENCE

*3D

A

THREE of more within 1 yr

  1. Tolerance
  2. Withdrawal
  3. Use over longer than intended
  4. Unsuccessful efforts to cut down
  5. Sig time to obtain/recover from substance
  6. Giving up social, work, recreation activities
  7. Use despite harm (physical/psych)

Mnemonic for dependence dx:
“totally will take U through absolute hell” - DEPEND on it

totally: tolerance
Will: withdrawal
take: time - use longer
U: unsuccessful at cutting down
through: time - sig to obtain/recover from
absolute: activities sacrificed for drug
Hell: harm to health (psych, physical)
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14
Q

Mnemonic for substance dependence dx (use disorders) - **remember, need 3 w/in a year

A

totally will take U through absolute hell - you can DEPEND on it

totally: tolerance
Will: withdrawal
take: time - use longer
U: unsuccessful at cutting down
through: time - sig to obtain/recover from
absolute: activities sacrificed for drug
Hell: harm to health (psych, physical)
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15
Q

Process for tx of substance abuse

A

how much is too much? tolerance + dependence + compulsion = NEED HELP

assessment: Primary care clinician in crisis center or ER

Tx: inpatient detox (hospital), inpatient rehab (14-28d+), outpatient rehab (IOP) or 1/2 way house, therapy (individual and group counseling-12step), inner circle support

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16
Q

principles of 12 step group therapy program

A

Admittance,
amends,
personal inventory,
service

17
Q

Overall medical mgmt. of substance dependence/ abuse

A

COMBO of therapy and meds

  • individual and group therapy
    • 1:1 counseling ie motivational interviewing, CBT, behavioral modification
  • -Groups: 12 step, specific support groups
  • MEDS
  • -detox (manage withdrawal sx)
  • -anti craving (weak or partial agonist)
  • -Long term maintenance (SSRIs, anxiolytics, naloxone, antabuse etc)

*be aware of Dual dx.. aka mentally ill, chemically addicted (that is, substance use disorder and co-morbid psych condition)

18
Q

alcohol detox tx

A

INPT

Delirium tremens:

  • Diazepam (valium)
  • Lorazepam (Ativan)
  • Phenobarbitol

Thiamine supplement

Long term: disulfiram (antabuse), Acamprosate (Campral), Naltrexone (revia), AA, individual counseling

19
Q

Tx Opiate addiction

A

DETOX: inpt if mod/severe

  • OD: naloxone (narcan)
  • Clonidine for SNS overstimulation
  • Substitution of longer acting opioid (methadone) - taper

Extended tx:

  • Methadone or Buprenorphine (suboxone) maintenance program - taper off
  • individual and group counseling (narcotics anonymous)
20
Q

What is Buprenorphine (suboxone)? and how does it work?

A

First med developed to treat opiate addiction in physicians office

  • binds same Mu receptors as Morphine w/o same effects
    • weak agonist: reduces cravings (mild withdrawal sx)
  • -Partial antagonist: prevents euphoria (low abuse potential)
    • Long acting and decreased respiratory depression (high safety profile)
  • requires DEA X license: addictionists
  • careful monitoring provides best success
21
Q

Conclusions/summaries re tx of substance abuse/dependence

A
be vigilant
appreciate the pathophysiology
know DSM
Use favorite screening tools
Have a plan (know where to refer)
Be VERY familiar of meds you rx
Be empathetic and supportive