Final

Question 1

GFR where meds start to get adjusted, what stage?

Answer 1

30-59

Stage 3

Question 2

Look at slide 8-9 (nephrology)

Answer 2

.

Question 3

Carbonic Anhydrase Inhibitors MOA

Answer 3

Inhibit CA which inhibits H+ secretion in the proximal tubule. Bicarb and sodium are blocked from reabsorption. Effect is short lived due to compensation at loop of Henle

Question 4

Osmotic Diuretics MOA

Answer 4

Non-reabsorbable solute filtered freely at the glomerulous. Uncouples sodium and water reabsorption by increasing the osmotic gradient in the proximal tubule. Sodium reabsorption initially, but water is not, leading to decreased sodium reabsorption distally

Question 5

Osmotic diuretic drugs (2)

Answer 5

Mannitol

Urea

Question 6

Osmotic diuretics excrete what through urine? (4)

Answer 6

• Water.
• Sodium.
• Chloride.
• Bicarbonate ion.

(Urinary pH is not altered by mannitol-induced osmotic diuresis.)

Question 7

I.V. mannitol _________ plasma osmolarity

Answer 7

increases